PROJECT 1: Penn State University's Translational Center for Child Maltreatment Studies (TCCMS)

项目 1：宾夕法尼亚州立大学儿童虐待研究转化中心 (TCCMS)

• 批准号: 10672568
• 负责人: Hannah Milena Caroline Schreier
• 金额: $ 72.04万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-20 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672568
• 关键词: Academic achievement; Adolescence; Adult; Age; Aging; American; Attention; Behavioral; Biological; Biological Sciences; Blood; Brain; Caregivers; Cell Aging; Characteristics; Child; Child Abuse and Neglect; Child Health; Child Welfare; Childhood; Chronic; Chronic Disease; Cognitive; Data; Development; Economic Burden; Elderly; Emotional; Enrollment; Epigenetic Process; Ethnic Origin; Exposure to; Female; Future; Gender; Genotype; Goals; Grant; Health; Immunologics; Interdisciplinary Study; Intervention; Investigation; Knowledge; Life; Life Cycle Stages; Life Experience; Literature; Longevity; Longitudinal cohort study; MRI Scans; Measurement; Mediating; Medical; Methods; Modeling; Molecular; Morbidity - disease rate; Neighborhoods; Neuronal Plasticity; Neurosecretory Systems; Outcome; Pathway interactions; Personal Satisfaction; Phase; Physiological; Population; Positioning Attribute; Prevention; Process; Prospective cohort; Psychosocial Factor; Publishing; Race; Reaction; Recording of previous events; Records; Recovery; Reporting; Reproducibility; Research; Resources; Risk; Risk Reduction; Role; Sampling; Science; Services; Severities; Sexual abuse; Stress; Survivors; System; Testing; Time; Tissues; Universities; Validation; Variant; Visit; Vulnerable Populations; Youth; aged; base; behavioral health; career preparation; child protective service; cohort; contextual factors; design; early life adversity; ethnic identity; ethnic minority; experience; health determinants; high risk; improved; intersectionality; male; minority children; mortality; neglect; person centered; physical abuse; physical conditioning; prospective; psychologic; psychosocial; pubertal timing; racial minority; resilience; rural area; social capital; stressor; success; urban area

PROJECT 1: PROJECT SUMMARY / ABSTRACT Over one third of U.S. youth are investigated for child maltreatment (CM) before the age of 18. CM represents an especially potent early life stressor with a profound impact on youth’s psychological and physical well-being. Among other things, CM increases the risk of many chronic diseases of aging, the roots of which can already be found during childhood and adolescence. Thus, a better understanding of the physiological mechanisms through which CM is associated with subsequent health is needed to improve the lifelong health trajectories of youth with a CM history, a high-risk yet understudied group, as well as to better understand biological mechanisms connecting early life adversity to later life health and well-being more generally. This project proposes the continuation of the Child Health Study (CHS; Project 1 of HD089922, PI: Noll), as part of which 525 youth aged 8-13 years who were recently investigated for CM as well as 175 comparison youth without a history of CM are being followed prospectively, completing biannual assessments. Taking advantage of this unique and exceptionally well-characterized cohort, we will follow youth as they arrive at the transition to adulthood, an important developmental period characterized by continued plasticity, the occurrence of many important developmental milestones, and with important implications for lifelong health and well-being. To this end, we will assess how early life experiences impact health during the transition to adulthood as well as the likelihood of a successful transition to adulthood (marked by greater academic achievement, career readiness, social capital, service continuity and reduced financial interdependence, early parenthood, and system involvement). In the process, we pay particular attention to the importance of key moderators (e.g., genotype, gender, race/ethnicity, pubertal timing, and neighborhood characteristics). Additionally, added emphasis is placed throughout on better understanding the experiences of racial/ethnic minority youth in the cohort (e.g., by examining the possible protective role of racial/ethnic identity) and to examine the impact of the intersectionality between race-related stressors and experiences of CM. Finally, we will also be able to leverage this cohort to understand in greater detail how various aspects of youth’s CM experiences and youth’s reactions to such experiences are differentially predictive of health and well-being during the transition to adulthood as well as a successful transition to adulthood more broadly. The interdisciplinary research team includes expertise in the assessment of biological embedding mechanisms and health among vulnerable youth and the retention of prospective cohorts of CM survivors. Resulting data will make important contributions to the CM and early life adversity literatures. It will also inform future prevention and intervention efforts with the ultimate goal of reducing the risk of adverse long-term health consequences among some of the most vulnerable individuals in the population.

项目1：项目总结/摘要 超过三分之一的美国青少年在18岁之前被调查虐待儿童（CM）。CM代表 这是一个特别强大的早期生活压力源，对青年的心理和身体健康产生深远影响。 除其他外，CM增加了许多慢性衰老疾病的风险，其根源已经可以 在儿童和青少年时期被发现。因此，更好地了解生理机制 通过CM与随后的健康相关联，需要改善患者的终身健康轨迹。 有CM病史的年轻人，一个高风险但研究不足的群体，以及更好地了解生物学 更普遍地将早期生活逆境与晚年健康和福祉联系起来的机制。这个项目 建议继续进行儿童健康研究（CHS; HD 089922的项目1，PI：Noll），作为其中的一部分， 525名最近接受CM调查的8-13岁青少年以及175名未接受CM调查的对照青少年。 正在前瞻性地跟踪CM的历史，完成一年两次的评估。趁这个 独特的和非常好的特点的群体，我们将跟踪青年，因为他们到达过渡到 成年期，一个重要的发展时期，其特点是持续的可塑性，许多事件的发生， 重要的发展里程碑，并对终身健康和福祉产生重要影响。本 最后，我们将评估早期生活经历如何影响向成年过渡期间的健康，以及 成功过渡到成年的可能性（以更高的学术成就，职业准备， 社会资本、服务的连续性和减少财务上的相互依赖、早为人父母和制度 参与）。在这个过程中，我们特别注意关键主持人的重要性（例如，基因型， 性别、种族/民族、青春期时间和邻居特征）。此外，还强调了 更好地了解种族/少数民族青年在队列中的经历（例如，通过 审查种族/族裔身份可能发挥的保护作用），并审查 种族相关的压力源和CM的经验之间的交叉性。最后，我们还将能够 利用这一群体，更详细地了解青年的CM经验和青年的 对这些经历的反应是不同的预测健康和福祉在过渡到 成年期以及更广泛地向成年期的成功过渡。跨学科研究团队 包括评估脆弱青年的生物嵌入机制和健康方面的专门知识 以及保留CM幸存者的前瞻性队列。由此产生的数据将对以下方面作出重要贡献： CM和早期生活逆境文献。它还将为今后的预防和干预工作提供信息， 最终目标是减少一些最不发达国家长期健康不良后果的风险， 人口中的弱势群体。