TOPIC 408: TOOLS AND TECHNOLOGIES FOR VISUALIZING MULTI-SCALE DATAPROJECT TITLE: SIMBIOSYS PHENOSCOPE: A CLOUD-ENABLED, WEB-BASED PORTAL FOR RAW AND

肿瘤之间的异质性和个体肿瘤内的ff差异继续向ff提出挑战，以开发出有效的治疗方法。正在产生大量数据，如单细胞测序、数字病理学和医学成像，以捕捉多个尺度上的异质性。然而，数据是孤立的，规模之间的联系仍然难以捉摸。SimBioSys PhenoScope是一种新的研究工具，可以协调这些不同的数据元素，连接基因组、细胞/途径、向微中心的组织环境和组织尺度。该工具正在开发中，用于生物标记物的发现。PhenoScope结合了最先进的机器学习、降维技术、新的时空模拟算法和对公共数据库的支持，提供了一种评估导致癌症表型行为的因素的新手段，从而可以阐明新的药效、预测、预测和替代生物标记物。在第二阶段合同期间，将开发该应用程序的测试版。SPECIfic的活动将包括：1)支持临床结果数据，2)用户自带数据的能力，3)交互式脚本/数据探索环境，4)兼容性和云部署增强，以及5)与客户进行Beta测试。这项技术使研究人员能够以新的视角研究癌症，并引领着即将到来的表型组学时代。

Heterogeneity among cancers and differences within individual tumors continue to challenge the efforts to develop effective therapies. A multitude of data such as single cell sequencing, digital pathology, and medical imaging are being generated to captures heterogeneityacross multiple scales. However, data is siloed and connections between scales remains elusive. SimBioSys PhenoScope is a novel research tool to harmonize these disparate data elements, connecting the genomic, cellular/pathway, microscropic tissue environment, and tissue scales. The tool is being developed for use in biomarker discovery. Combining state-of-the-artmachine learning, dimensionality reduction techniques, novel spatio-temporal simulation algorithms, and support for public data repositories, PhenoScope provides a new means of assessing factors contributing to a cancer's phenotypical behavior, thereby allowing elucidation of new pharmacodynamic, prognostic, predictive,and surrogate biomarkers. During the Phase II contract, a beta version of the application will be developed. Specific activities will include: 1) support for clinical outcomes data, 2) capabilities for users to bring their own data, 3) an interactive scripting/data exploration environment, 4) compatibility and cloud deployment enhancements, and 5) beta testing with customers. This technology enables researchers to study cancer in a new light, and leads the way in to the upcoming phenomics era.