Statistical methods in collaborative research

与校内外研究者的合作研究取得了丰硕的成果。与米勒博士合作开展的工作描述了基于社区的covid - 19检测地点，并发表在MMWR上。与CRU的莱德博士和米勒博士合作的项目重点是皮肌炎，一种罕见的炎症性疾病。我们目前正在进行肌炎患者钙质沉积症的GWAS研究，扩展HLA单倍型和罕见肌肉变异与肌炎的关联研究，以及血液分子测量（ND1，细胞游离DNA和GAPDH）与自身免疫性疾病之间关系的研究。我正在与莱德博士合作，制定一个从实验到临床的建议，其中将评估omega - 3脂肪酸补充剂对皮肌炎的影响。在与Kleeberger博士的合作项目中，我们正在研究线粒体基因组变异对极早产儿支气管肺发育不良风险的影响。我与DNTP迪克森博士实验室的研究人员合作，研究镉暴露对细胞核迁移模式的影响。在与尼日利亚访问学者Kana博士的合作中，我们使用2018年尼日利亚人口与健康调查的数据评估了产前接触生物质燃料与出生体重之间的关系。我们与Garantziotis博士一起研究了COVID抗体的模式。基于与李晓玲和斯蒂芬妮·伦敦实验室的合作，我们正在准备两份手稿。与RDBL Williams博士实验室的Savy博士合作研究超排卵卵母细胞受精后的钙振荡，与GISBL Copelands博士实验室的Gustafson博士合作研究SSBP1变异的分子动力学模拟，已经发表了两篇论文。

The collaborative research with intramural and extramural investigators has been fruitful. The work in collaboration with Dr. Miller described community-based testing sites for COVID19 was published in MMWR. The projects with Drs Rider and Miller from CRU focus on dermatomyositis, a rare inflammatory disease. We are now conducting a GWAS study of calcinosis in myositis patients, an association study of extended HLA haplotypes and rare muscle variants and myositis, and a study investigating relationship between blood molecular measurements (ND1, cell free DNA and GAPDH) and autoimmune diseases. I am working with Dr. Rider to put together a bench-to-bedside proposal in which effects of Omega3 fatty acid supplementation on dermatomyositis will be evaluated. In a collaborative project with Dr. Kleeberger we are studying the impact of variants in the mitochondrial genome on the risk of bronchopulmonary dysplasia in very preterm infants. I collaborated with researchers from Dr. Dixons lab at DNTP on projects that study effects of Cadmium exposure on nucleus migration patterns. In the work with Dr. Kana, a visitor scholar from Nigeria, we assessed the association between prenatal exposure to biomass fuel and birthweight using data from 2018 Nigeria Demographic and Health Survey. Working with Dr. Garantziotis we studied the pattern of COVID antibodies overtime. We are preparing two manuscripts based on the collaborations with Xiaoling Lis and Stephanie Londons labs.The collaborative works with Dr. Savy from Dr. Williams lab in RDBL on calcium oscillation after fertilization in superovulated oocytes and with Dr. Gustafson from Dr. Copelands lab in GISBL on molecular dynamic simulation of SSBP1 variants have produced two publications.