Statistical methods in collaborative research

合作研究中的统计方法

• 批准号: 10699689
• 负责人: Min Shi
• 金额: $ 16.95万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699689
• 关键词: Antibodies; Area; Autoimmune Diseases; Biological; Blood; Bronchopulmonary Dysplasia; COVID-19; Cadmium; Calcinosis; Calcium Oscillations; Cell Nucleus; Collaborations; Communities; Data; Data Analyses; Demographic and Health Surveys; Dermatomyositis; Disease; Exposure to; Extramural Activities; Fertilization; Goals; Haplotypes; Inflammatory; London; Manuscripts; Measurement; Molecular; Muscle; Myositis; Nigeria; Omega-3 Fatty Acids; Oocytes; Patients; Pattern; Premature Infant; Publications; Publishing; Research; Research Personnel; Research Project Grants; Risk; Site; Statistical Methods; Testing; Variant; Work; Writing; base; bench to bedside; biomass fuel; cell free DNA; coronavirus disease; design; experimental study; fatty acid supplementation; genetic epidemiology; genome wide association study; method development; migration; mitochondrial genome; prenatal exposure; simulation

The collaborative research with intramural and extramural investigators has been fruitful. The work in collaboration with Dr. Miller described community-based testing sites for COVID19 was published in MMWR. The projects with Drs Rider and Miller from CRU focus on dermatomyositis, a rare inflammatory disease. We are now conducting a GWAS study of calcinosis in myositis patients, an association study of extended HLA haplotypes and rare muscle variants and myositis, and a study investigating relationship between blood molecular measurements (ND1, cell free DNA and GAPDH) and autoimmune diseases. I am working with Dr. Rider to put together a bench-to-bedside proposal in which effects of Omega3 fatty acid supplementation on dermatomyositis will be evaluated. In a collaborative project with Dr. Kleeberger we are studying the impact of variants in the mitochondrial genome on the risk of bronchopulmonary dysplasia in very preterm infants. I collaborated with researchers from Dr. Dixons lab at DNTP on projects that study effects of Cadmium exposure on nucleus migration patterns. In the work with Dr. Kana, a visitor scholar from Nigeria, we assessed the association between prenatal exposure to biomass fuel and birthweight using data from 2018 Nigeria Demographic and Health Survey. Working with Dr. Garantziotis we studied the pattern of COVID antibodies overtime. We are preparing two manuscripts based on the collaborations with Xiaoling Lis and Stephanie Londons labs.The collaborative works with Dr. Savy from Dr. Williams lab in RDBL on calcium oscillation after fertilization in superovulated oocytes and with Dr. Gustafson from Dr. Copelands lab in GISBL on molecular dynamic simulation of SSBP1 variants have produced two publications.

与校内和校外研究人员的合作研究取得了丰硕成果。与米勒博士合作的这项工作描述了COVID 19的社区测试地点，并发表在MMWR上。来自CRU的Rider和米勒博士的项目集中在皮肌炎，一种罕见的炎症性疾病。我们现在正在进行一项关于肌炎患者钙质沉着的GWAS研究，一项关于扩展HLA单倍型和罕见肌肉变异与肌炎的关联研究，以及一项关于血液分子测量（ND1，细胞游离DNA和GAPDH）与自身免疫性疾病之间关系的研究。我正在与Rider博士合作，提出一个从实验室到床边的建议，其中将评估Omega3脂肪酸补充剂对皮肌炎的影响。在与Kleeberger博士的合作项目中，我们正在研究线粒体基因组变异对极早产儿支气管肺发育不良风险的影响。我与DNTP的Dixons博士实验室的研究人员合作，研究镉暴露对细胞核迁移模式的影响。在与来自尼日利亚的访问学者Kana博士的合作中，我们使用2018年尼日利亚人口与健康调查的数据评估了产前接触生物质燃料与出生体重之间的关联。我们与Garantziotis博士一起研究了COVID抗体的模式。我们正在准备两份基于与Xiaoling Lis和Stephanie Londons实验室合作的手稿。与RDBL威廉姆斯博士实验室的Savy博士在超数排卵卵母细胞受精后的钙振荡方面的合作以及与GISBL Copelands博士实验室的Gustafson博士在SSBP 1变体的分子动力学模拟方面的合作已经产生了两份出版物。