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Statistical methods in collaborative research

合作研究中的统计方法

基本信息

批准号：
10928619
负责人：
Min Shi
金额：
$ 26.33万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10928619
关键词：
Age Area Autoimmune Diseases Biological Breast Cancer Risk Assessment Tool Breast Cancer Risk Factor Calcinosis Carotenoids Case/Control Studies Clinical Trials Cohort Studies Collaborations Data Data Analyses Dermatomyositis Diagnosis Environment Epidemiology Event Extramural Activities Genetic Genetic Epistasis Genetic Programming Genetic study Goals Haplotypes Hypoventilation Inflammatory Life London Lutein Manuscripts Mental Depression Methods Modeling Mus Muscle Muscular Dystrophies Myositis Omega-3 Fatty Acids Paper Parents Patients Performance Phenotype Publishing Race Research Research Design Research Personnel Research Project Grants Rheumatism Sampling Sex Differences Sister Sleep Sleep Apnea Syndromes Statistical Methods Twin Multiple Birth Variant Work Writing cohort cytokine design epidemiology study experimental study fatty acid supplementation fetal genome wide association study human subject method development pulmonary function respiratory risk prediction model risk variant simulation study characteristics time-to-pregnancy trend zeaxanthin

项目摘要

One focus of this project is on developing statistical methods for genetic and epidemiology studies. Working with Drs. Nodzenski, Weinberg and Umbach, we have extended the previously published method GADGETS, a genetic-algorithm-based method to identify genetic epistatic effects using data from case-parent triads, to studies of environment-epistasis interaction, maternal genetic effects and fetal-maternal interaction effects. The work with Dr. Weinberg focusing on assessing the performance of beta-geometric models in time-to-pregnancy studies was published in Epidemiology in 2023. In a project working with Drs. Weinberg and Umbach we are developing a method for pooled sample analysis using a case-cohort study design and our simulation studies have shown that pooling up to 8 samples only caused modest loss of power. We are also extending the method to assessment of exposure quantile effects using pooled samples from a case-cohort or case-control study. I actively participate in several applied studies collaborating with multiple researchers in BCBB branch. Collaborating with Dr. Lis group we are analyzing the sleep data collected through UNC Sleep Center. In the paper published in BMJ Open Respiratory Research, we studied the characteristics of and relationship between sleep apnea and hypoventilation in patients with muscular dystrophy. We are performing analysis to assess the sex difference in sleep apnea and its trend with age and the relationship between depression and sleep apnea. Working with Dr. Diaz Santanas group we are using data from the Sister Study to validate two popular breast cancer risk prediction models, BOADICEA and Gail models. In a project led by Drs. Holle and Park, we performed a GWAS analysis of 5 carotenoid phenotypes and identified an association between a common SNP and lutein and zeaxanthin levels. I also collaborate extensively with intramural investigators from other branches as well as extramural investigators. The research of Dr Rider from CRU focuses on autoimmune diseases, in particular, dermatomyositis, a rare inflammatory autoimmune disease. I work closely with Dr. Riders group on several projects. We are finishing up writing a paper describing the GWAS study of calcinosis in myositis patients. In another project we evaluated the association between extended HLA haplotypes and rare muscle variants and myositis. Using data from the Twin-Sib study we found an association between systemic rheumatic diseases and life events in the years prior to their diagnosis. I am also working with Dr. Rider to write a clinical trial proposal which focuses on the effects of Omega3 fatty acid supplementation on dermatomyositis. In a collaborative work with Huiling Li from Dr. Londons lab we are preparing a manuscript describing the impact on pulmonary functions in Adam19 deficient mice. Working Dr. Fesslers group we identified race-specific association of IRGM risk alleles with cytokine expression in human subjects.

该项目的重点之一是开发遗传学和流行病学研究的统计方法。Nodzenski，温伯格和Umbach博士的工作，我们已经扩展了以前发表的方法GADGETS，一个基于遗传算法的方法，以确定遗传上位性效应，使用数据从父母的黑社会，研究环境上位性相互作用，母体遗传效应和胎儿-母体相互作用的影响。与温伯格博士合作的工作重点是评估β几何模型在妊娠时间研究中的性能，该研究于2023年发表在《流行病学》杂志上。在与温伯格和Umbach博士合作的一个项目中，我们正在开发一种使用病例队列研究设计的合并样本分析方法，我们的模拟研究表明，合并多达8个样本仅会导致适度的功效损失。我们还将该方法扩展到使用来自病例队列或病例对照研究的合并样本评估暴露分位数效应。我积极参与了几项应用研究与多名研究人员在BCBB分支。与Lis博士团队合作，我们正在分析通过睡眠中心收集的睡眠数据。在BMJ Open Respiratory Research上发表的论文中，我们研究了肌营养不良症患者睡眠呼吸暂停和通气不足的特点和关系。我们正在进行分析，以评估睡眠呼吸暂停的性别差异及其随年龄的变化趋势，以及抑郁症与睡眠呼吸暂停之间的关系。与迪亚兹桑塔纳斯博士团队合作，我们正在使用姐妹研究的数据来验证两种流行的乳腺癌风险预测模型，BOADICEA和Gail模型。在Holle和Park博士领导的一个项目中，我们对5种类胡萝卜素表型进行了GWAS分析，并确定了常见SNP与叶黄素和玉米黄质水平之间的关联。我还与来自其他分支机构的内部调查人员以及外部调查人员进行了广泛的合作。来自CRU的Rider博士的研究重点是自身免疫性疾病，特别是皮肌炎，这是一种罕见的炎症性自身免疫性疾病。我与Dr. Riders团队在多个项目上密切合作。我们即将完成一篇描述GWAS对肌炎患者钙质沉着的研究的论文。在另一个项目中，我们评估了扩展的HLA单倍型与罕见肌肉变异和肌炎之间的关联。利用双同胞研究的数据，我们发现全身性风湿性疾病与诊断前几年的生活事件之间存在关联。我也正在与Rider博士合作撰写一份临床试验提案，重点关注Omega3脂肪酸补充剂对皮肌炎的影响。在与来自伦敦实验室的Huiling Li博士的合作中，我们正在准备一份描述Adam19缺陷小鼠肺功能影响的手稿。Fesslers博士的工作组确定了人类受试者中IRGM风险等位基因与细胞因子表达的种族特异性关联。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Approaches for Assessing Effects of Exposures on Human Fertility.

评估暴露对人类生育力影响的方法。

DOI：
10.1097/ede.0000000000001575
发表时间：
2023
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
0
作者：
Shi,Min;Weinberg,ClariceR
通讯作者：
Weinberg,ClariceR

Association between Mitochondrial DNA Sequence Variants and V˙O2 max Trainability.

DOI：
10.1249/mss.0000000000002390
发表时间：
2020-11
期刊：
MEDICINE & SCIENCE IN SPORTS & EXERCISE
影响因子：
4.1
作者：
Vellers, Heather L.;Verhein, Kirsten C.;Burkholder, Adam B.;Lee, Jaehoon;Kim, Youngmin;Lightfoot, J. Timothy;Shi, Min;Weinberg, Clarice R.;Sarzynski, Mark A.;Bouchard, Claude;Kleeberger, Steven R.
通讯作者：
Kleeberger, Steven R.

Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice.

丁丙诺啡、氯己定和低强度激光治疗对小鼠伤口愈合的影响。

DOI：
10.30802/aalas-cm-20-000104
发表时间：
2021
期刊：
Comparative medicine
影响因子：
0.8
作者：
Webb,DonnaR;Churchill,ShebaR;Hill,GeorgetteD;McGee,ChristopherA;Shi,Min;King-Herbert,AngelaP;Blankenship-Paris,TerryL
通讯作者：
Blankenship-Paris,TerryL

"Metalloestrogenic" effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells.