Clinical and Translational Science Center

临床和转化科学中心

• 批准号: 10673813
• 负责人: JULIANNE L IMPERATO-MCGINLEY
• 金额: $ 996.71万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-05 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673813
• 关键词: Adoption; Animals; Area; Atmosphere; Award; Bioinformatics; Biomedical Research; COVID-19 pandemic; Center for Translational Science Activities; Child; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Community Health; Community Networks; Community Outreach; Computer software; Country; Development; Device or Instrument Development; Discipline; Disease; Education; Educational process of instructing; Elderly; Ensure; Entrepreneurship; Ethics; Fostering; Funding; Future; Future Generations; Generations; Goals; Health; Home; Hospitals; Human; Informatics; Infrastructure; Institution; Medical center; Medicine; Memorial Sloan-Kettering Cancer Center; Multi-Institutional Clinical Trial; New York; New York City; Operative Surgical Procedures; Orthopedics; Pathway interactions; Population; Presbyterian Church; Preventive Medicine; Process; Program Development; Public Health; Published Comment; Radial; Research; Research Personnel; Research Training; Resources; School Nursing; Science; Self Stimulation; Series; Site; Special Hospitals; Special Population; Strategic Planning; Students; System; TNFSF15 gene; Training; Translating; Translational Research; Universities; Vaccination; Walking; Work; base; career; career development; clinical translation; collaborative environment; college; community based participatory research; community engagement; community organizations; computing resources; design; disability; equity, diversity, and inclusion; ethnic minority; graduate school; hackathon; health disparity; health inequalities; high standard; improved; innovation; invention; lectures; medical schools; multidisciplinary; novel; opioid epidemic; outreach; pandemic impact; precision medicine; programs; racial minority; research study; symposium; synergism; therapeutic development; translational research program; translational study; underserved area; underserved community; urban public health; urban school; vaccine hesitancy; virtual; web portal

Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L OVERALL PROJECT SUMMARY/SUMMARY The Weill Cornell Medicine Clinical and Translational Science Center’s (CTSC) future strategies are built on the considerable accomplishments achieved over the last 14 years, providing the translation of research and the generation of research ideas that pave the way for future innovations despite the effect of the pandemic on the medical school, with the city in lockdown for over 14 months. The plans for the next five years are devised to continue to develop the existing infrastructure and its initiatives, to add new ones, to enhance networking, and to improve diversity, equity, and inclusion. In so doing, we will continue to advance translational science to improve community health. With our multi-institutional hub of distinguished partners firmly in place, the strategic plans for the CTSC are geared to rapidly advance translational science discovery by: 1) Enhancing informatics to increase resource adoption, reduce roadblocks and streamline workflow through training, novel software, and new collaborations; 2) Improving health inequities, developing strong translational research engagement with communites, and preparing for health crises, like the COVID-19 pandemic, where the CTSC organized a vaccination hesitancy program and set up vaccination sites in underserved communities; 3) Continuing to develop our highly successful clinical and translational education programs through innovative and entrepreneurial multifaceted initiatives including training in health disparities and a new cross-hub KL2/TL1 collaboration with the Georgetown/Howard CTSA; and 4) Creating Team Science initiatives that promote inclusion across the CTSC. Innovative didactic opportunities will continue to be offered and expanded, such as seminars on innovation and entrepreneurship, the newest of which will be a collaborate with eLab on “Unmet Needs for Stimulating Device Development,” a five-part series which is designed to stimulate device development. The Pilot Translational and Clinical Studies program will be enhanced to target projects in device and therapeutics development, precision medicine and research in special populations while promoting collaborations between the community, community organizations and CTSC Investigators. The CTSC also offers educative opportunities that reach the broader community such as our Teaching Ethics Through Art program, while the Special Population Network (SPN) will expand to include community outreach studies and continue clinical research studies with a focus on the following populations: children, the elderly, ethnic and racial minorities and those with disabilities. Additionally, the Network Capacity Component will do more outreach to encourage local investigators to initiate multi-center clinical trials. The CTSC has also been extremely successful ensuring the availability of biostatisticians from all partners with expertise in diverse disease systems and with adequate computational resources to support the design and conduct of research studies performed within the CTSC. All of these initiatives allow the CTSC to accomplish its goal of translating science to improve public health more effectively and efficiently. Project Summary/Abstract Page 298 Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L

联系PD/PI: IMPERATO-MCGINLEY， JULIANNE L

项目成果

Seven-Year Durability of Improvements in Urinary Incontinence After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.

• DOI: 10.1001/jamanetworkopen.2022.46057
• 发表时间: 2022-12-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: King, Wendy C.;Hinerman, Amanda S.;Subak, Leslee L.
• 通讯作者: Subak, Leslee L.

Bereavement risk screening: A pathway to psychosocial oncology care.

• DOI: 10.1002/pon.5526
• 发表时间: 2020-12
• 期刊: Psycho-oncology
• 影响因子: 3.6
• 作者: Roberts KE;Jankauskaite G;Slivjak E;Rubin L;Schachter S;Stabler S;Wiener L;Prigerson HG;Lichtenthal WG
• 通讯作者: Lichtenthal WG

Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse.

• DOI: 10.4049/jimmunol.2000951
• 发表时间: 2021-04-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Ah Kioon MD;Pierides M;Pannellini T;Lin G;Nathan CF;Barrat FJ
• 通讯作者: Barrat FJ

The progesterone-receptor modulator, ulipristal acetate, drastically lowers breast cell proliferation.

孕激素调节剂，乙酸乌里普赛，大大降低了乳腺细胞的增殖。

• DOI: 10.1007/s10549-021-06503-1
• 发表时间: 2022-04
• 期刊: BREAST CANCER RESEARCH AND TREATMENT
• 影响因子: 3.8
• 作者: Westhoff, Carolyn L.;Guo, Hua;Wang, Zhong;Hibshoosh, Hanina;Polaneczky, Margaret;Pike, Malcolm C.;Ha, Richard
• 通讯作者: Ha, Richard

Adapting psychosocial interventions for older adults with cancer: A case example of Managing Anxiety from Cancer (MAC).

适应癌症老年人的社会心理干预措施：管理癌症焦虑（MAC）的一个例子。

• DOI: 10.1016/j.jgo.2020.03.012
• 发表时间: 2020-11
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Trevino KM;Stern A;Prigerson HG
• 通讯作者: Prigerson HG