CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

CTSA 儿科研究基础设施

• 批准号: 8366102
• 负责人: JULIANNE L IMPERATO-MCGINLEY
• 金额: $ 147.33万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366102
• 关键词: Center for Translational Science Activities; Clinical Sciences; Pediatric Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The development of the Clinical and Translational Science Center (CTSC) fulfills the mission to advance the nation's clinical research enterprise of moving translational research seamlessly from bench to bedside and to the community. The Center represents our vision to deliver the vast knowledge of recent biomedical advances to clinical application for meaningful healthcare practices and to nurture multidisciplinary translational research education and training. The CTSC has been designed to capture the collective of intellectual capital, cutting-edge resources and diverse patient base of partnering institutions and to integrate them for maximum translational research benefits. As lead institution, Weill Cornell Medical Center (WCMC) will serve as an academic home through which essential resources, technological tools and education programs can be efficiently shared and managed. The partner institutions comprising the CTSC are also neighbors located on York Avenue. Within the immediate area are: WCMC, including Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences and the Weill Cornell Campus of NewYork-Presbyterian Hospital; Memorial Sloan-Kettering Cancer Center; and the Hospital for Special Surgery. In close proximity on the East Side of Manhattan are: Hunter College School of Nursing, Hunter College Center for the Study of Gene Structure and Function/Research Center for Minority Institutions and the Cornell University Cooperative Extension in New York City. The resulting cluster of institutions forms a unique and cohesive biomedical complex fulfilling the NIH roadmap initiative of breaking-down institutional and disciplinary silos to accelerate translational research. Separately, the partner institutions are superb centers of intellectual and academic excellence, thus their integration into the CTSC will harness their distinctive characteristics and hasten clinical and translational research breakthroughs for improved patient care. The trans-institutional governance structure outlined in this application and supplemented by a comprehensive systems-based evaluation process are important in overcoming bureaucracies and barriers. New initiatives were sculpted and programs with a history of collaboration between partners were broadened and restructured. The key elements of the CTSC are: 1) development of novel clinical and translational methodologies; 2) pilot and collaborative translational and clinical studies; 3) biomedical informatics; 4) design, biostatistics and clinical research ethics; 5) regulatory knowledge and support; 6) participant and clinical interaction resources; 7) community engagement and research; 8) translational technologies and resources; 9) research education, training and career development; and 10) other program functions. The CTSC is a vital link between the academic, research and clinical practice functions of partner institutions and will provide an important continuum in translational research.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 临床和翻译科学中心(CTSC)的发展完成了推动国家临床研究事业无缝地将翻译研究从工作台转移到床边和社区的使命。该中心代表了我们的愿景，即将最新生物医学进展的广泛知识应用于临床，进行有意义的医疗实践，并培养多学科的翻译研究、教育和培训。CTSC旨在收集合作机构的智力资本、尖端资源和不同的患者基础，并将它们整合在一起，以实现最大的翻译研究效益。作为牵头机构，威尔康奈尔医学中心(WCMC)将作为一个学术之家，通过它可以有效地共享和管理必要的资源、技术工具和教育项目。组成反恐委员会的伙伴机构也是位于约克大道的邻居。紧邻地区有：WCMC，包括威尔·康奈尔医学院、威尔·康奈尔医学研究生院和纽约长老会医院威尔·康奈尔校区；纪念斯隆-凯特琳癌症中心；以及特殊外科医院。距离曼哈顿东侧很近的有：亨特学院护理学院、亨特学院基因结构和功能研究中心/少数族裔机构研究中心和纽约市康奈尔大学合作分校。由此产生的机构集群形成了一个独特的、有凝聚力的生物医学综合体，履行了NIH路线图倡议，即打破机构和学科孤岛，以加速转化性研究。另外，合作机构是卓越的智力和学术卓越中心，因此，它们与CTSC的整合将利用它们的独特特点，并加快临床和翻译研究的突破，以改善患者护理。本申请书中概述的跨机构治理结构，并辅之以基于系统的全面评价进程，对于克服官僚作风和障碍非常重要。制定了新的倡议，扩大和重组了合作伙伴之间有合作历史的项目。CTSC的关键要素是：1)开发新的临床和翻译方法；2)试验性和协作性的翻译和临床研究；3)生物医学信息学；4)设计、生物统计学和临床研究伦理；5)监管知识和支持；6)参与者和临床互动资源；7)社区参与和研究；8)翻译技术和资源；9)研究教育、培训和职业发展；以及10)其他计划职能。CTSC是合作机构的学术、研究和临床实践职能之间的重要纽带，将为翻译研究提供重要的连续体。