Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
基本信息
- 批准号:10673705
- 负责人:
- 金额:$ 61.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-12-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:ArchitectureBiological AssayBiosensorBlood GlucoseCell SurvivalCellular biologyChemicalsClinicalContinuous Glucose MonitorDataDependenceDeteriorationDevelopmentDevicesDiabetes MellitusDiseaseElectrospinningFDA approvedFamily suidaeFiberForeign BodiesFundingFutureGene Expression ProfilingGeneticGlucoseHealthHistocompatibilityImmune responseImpaired wound healingImplantIn VitroIndividualInsulinInsulin-Dependent Diabetes MellitusKnowledgeMediatingMembraneModificationMolecularMorphologyNitric OxideNitric Oxide DonorsPerformancePhasePolyurethanesPorosityProtocols documentationQuality of lifeReactionReportingResearchRoleSignal TransductionSilicon DioxideSulfhydryl CompoundsSystemSystems BiologyTestingThickTissuesVascularizationWorkbiomaterial compatibilitycapsulecommercializationdesigndiabeticexpirationfabricationglucose monitorglucose sensorimplantationimplanted sensorimprovedin vivoin vivo evaluationmonitoring devicenext generationnon-diabeticparticleperformance testsporcine modelpreventresponsesensorusabilitywound healing
项目摘要
PROJECT SUMMARY
The objective of this project is to study the analytical performance benefits of nitric oxide (NO)-releasing
percutaneously implanted glucose sensors in a diabetic swine model as a function of NO-release duration sensor
membrane porosity, and diabetes state (i.e., insulin versus non-insulin dependent). Continuous glucose monitoring
(CGM) devices with superior usability (i.e., for immediate use and extended duration) would greatly increase the
ability of those afflicted with diabetes to successfully manage their disease. In the prior funding period, we
demonstrated in a non-insulin dependent diabetic swine model that NO-releasing sensor membranes both lessen the
FBR and facilitate improved analytical sensor performance up to 28 days—the longest duration evaluated. However,
CGM devices are intended for insulin-dependent individuals and longer implantation periods would improve device
utility/value. The variance in FBR and in vivo sensor performance for insulin- and non-insulin-dependent subjects is
currently unknown but likely significant due to more impaired wound healing mechanisms. We hypothesize that the
improvements in FBR and sensor performance that we have reported sensor membranes that release NO for 28 days
will be extended to at least two months by using porous sensor membranes that release for 60+ days and passively
promote healthy re-vascularization in the proximity of the sensor. Through our work, we will study the influence of
both NO release and porosity on tissue biocompatibility and sensor performance as a function of diabetes. In this
respect, we will generate new knowledge on how diabetes influences the tissue integration and in vivo sensor
performance.
项目总结
本项目的目标是研究一氧化氮(NO)释放对分析性能的好处
糖尿病猪模型经皮植入葡萄糖传感器作为NO释放持续时间传感器的作用
膜孔隙率和糖尿病状态(即胰岛素与非胰岛素依赖)。连续血糖监测
具有卓越可用性(即立即使用和延长使用寿命)的(CGM)设备将极大地增加
糖尿病患者成功控制疾病的能力。在之前的资助期,我们
在非胰岛素依赖型糖尿病猪模型中证明,NO释放感受器膜既可以减少
FBR和促进改进的分析传感器性能长达28天--评估的最长持续时间。然而,
CGM装置是为胰岛素依赖者设计的,更长的植入周期将改善装置
效用/价值。胰岛素依赖型和非胰岛素依赖型受试者的FBR和体内传感器性能的差异是
目前尚不清楚,但由于更多的伤口愈合机制受损,可能意义重大。我们假设
FBR和传感器性能的改善,我们已经报告了28天释放NO的传感器膜
通过使用可被动释放60天以上的多孔感应膜,可延长到至少两个月
促进传感器附近健康的血管重建。通过我们的工作,我们将研究
糖尿病对组织生物相容性和传感器性能的影响包括NO释放和孔隙率。在这
在这方面,我们将产生关于糖尿病如何影响组织整合和体内传感器的新知识
性能。
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility.
- DOI:10.1021/acs.analchem.6b04251
- 发表时间:2017-01-03
- 期刊:
- 影响因子:7.4
- 作者:Soto RJ;Hall JR;Brown MD;Taylor JB;Schoenfisch MH
- 通讯作者:Schoenfisch MH
Influence of diabetes on the foreign body response to nitric oxide-releasing implants.
- DOI:10.1016/j.biomaterials.2017.11.044
- 发表时间:2018-03
- 期刊:
- 影响因子:14
- 作者:Soto RJ;Merricks EP;Bellinger DA;Nichols TC;Schoenfisch MH
- 通讯作者:Schoenfisch MH
Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.
- DOI:10.1021/acsbiomaterials.2c00392
- 发表时间:2022-05
- 期刊:
- 影响因子:5.8
- 作者:Sara E. Maloney;Christopher A. Broberg;Quincy E Grayton;Samantha L Picciotti;Hannah R Hall;S. Wallet;R. Maile;M. Schoenfisch
- 通讯作者:Sara E. Maloney;Christopher A. Broberg;Quincy E Grayton;Samantha L Picciotti;Hannah R Hall;S. Wallet;R. Maile;M. Schoenfisch
Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release.
通过氨基硅烷表面活性剂离子交换反应功能化介孔二氧化硅:受控支架设计和一氧化氮释放。
- DOI:10.1021/acsami.5b10942
- 发表时间:2016
- 期刊:
- 影响因子:9.5
- 作者:Soto,RobertJ;Yang,Lei;Schoenfisch,MarkH
- 通讯作者:Schoenfisch,MarkH
Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
- DOI:10.3390/ijms231911635
- 发表时间:2022-10-01
- 期刊:
- 影响因子:5.6
- 作者:
- 通讯作者:
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Mark H Schoenfisch其他文献
Mark H Schoenfisch的其他文献
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{{ truncateString('Mark H Schoenfisch', 18)}}的其他基金
Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease
释放一氧化氮的透明质酸疗法用于治疗牙周病
- 批准号:
10657158 - 财政年份:2023
- 资助金额:
$ 61.65万 - 项目类别:
Nitric oxide-releasing glycosaminoglycans for treating complex wounds
释放一氧化氮的糖胺聚糖用于治疗复杂伤口
- 批准号:
10584269 - 财政年份:2023
- 资助金额:
$ 61.65万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
10263316 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Nitric oxide-releasing dendrimers for the treatment of periodontal disease
释放一氧化氮的树枝状聚合物用于治疗牙周病
- 批准号:
8927301 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Nitric oxide-releasing dendrimers for the treatment of periodontal disease
用于治疗牙周病的释放一氧化氮的树枝状聚合物
- 批准号:
9261511 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
10418787 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
9185309 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Nitric oxide-releasing dendrimers for the treatment of periodontal disease
释放一氧化氮的树枝状聚合物用于治疗牙周病
- 批准号:
9104134 - 财政年份:2015
- 资助金额:
$ 61.65万 - 项目类别:
Nitric oxide-releasing cystic fibrosis therapeutics
释放一氧化氮的囊性纤维化疗法
- 批准号:
8968231 - 财政年份:2014
- 资助金额:
$ 61.65万 - 项目类别:
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