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Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors

糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用

基本信息

批准号：
10673705
负责人：
Mark H Schoenfisch
金额：
$ 61.65万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673705
关键词：
Architecture Biological Assay Biosensor Blood Glucose Cell Survival Cellular biology Chemicals Clinical Continuous Glucose Monitor Data Dependence Deterioration Development Devices Diabetes Mellitus Disease Electrospinning FDA approved Family suidae Fiber Foreign Bodies Funding Future Gene Expression Profiling Genetic Glucose Health Histocompatibility Immune response Impaired wound healing Implant In Vitro Individual Insulin Insulin-Dependent Diabetes Mellitus Knowledge Mediating Membrane Modification Molecular Morphology Nitric Oxide Nitric Oxide Donors Performance Phase Polyurethanes Porosity Protocols documentation Quality of life Reaction Reporting Research Role Signal Transduction Silicon Dioxide Sulfhydryl Compounds System Systems Biology Testing Thick Tissues Vascularization Work biomaterial compatibility capsule commercialization design diabetic expiration fabrication glucose monitor glucose sensor implantation implanted sensor improved in vivo in vivo evaluation monitoring device next generation non-diabetic particle performance tests porcine model prevent response sensor usability wound healing

项目摘要

PROJECT SUMMARY The objective of this project is to study the analytical performance benefits of nitric oxide (NO)-releasing percutaneously implanted glucose sensors in a diabetic swine model as a function of NO-release duration sensor membrane porosity, and diabetes state (i.e., insulin versus non-insulin dependent). Continuous glucose monitoring (CGM) devices with superior usability (i.e., for immediate use and extended duration) would greatly increase the ability of those afflicted with diabetes to successfully manage their disease. In the prior funding period, we demonstrated in a non-insulin dependent diabetic swine model that NO-releasing sensor membranes both lessen the FBR and facilitate improved analytical sensor performance up to 28 days—the longest duration evaluated. However, CGM devices are intended for insulin-dependent individuals and longer implantation periods would improve device utility/value. The variance in FBR and in vivo sensor performance for insulin- and non-insulin-dependent subjects is currently unknown but likely significant due to more impaired wound healing mechanisms. We hypothesize that the improvements in FBR and sensor performance that we have reported sensor membranes that release NO for 28 days will be extended to at least two months by using porous sensor membranes that release for 60+ days and passively promote healthy re-vascularization in the proximity of the sensor. Through our work, we will study the influence of both NO release and porosity on tissue biocompatibility and sensor performance as a function of diabetes. In this respect, we will generate new knowledge on how diabetes influences the tissue integration and in vivo sensor performance.

项目摘要本项目的目的是研究一氧化氮（NO）释放的分析性能的好处在糖尿病猪模型中作为NO释放持续时间传感器的函数的Percent植入葡萄糖传感器膜孔隙率和糖尿病状态（即，胰岛素与非胰岛素依赖性）。持续葡萄糖监测 (CGM)具有上级可用性的设备（即，立即使用和延长期限）将大大增加糖尿病患者成功控制疾病的能力。在上一个融资周期，我们在非胰岛素依赖性糖尿病猪模型中证实，NO释放传感器膜既减少了 FBR和促进提高分析传感器性能长达28天-评估的最长持续时间。然而，在这方面， CGM器械预期用于胰岛素依赖型个体，较长的植入期将改善器械效用/价值。胰岛素依赖和非胰岛素依赖受试者的FBR和体内传感器性能的方差为目前尚不清楚，但由于伤口愈合机制受损更严重，可能具有显著意义。我们假设 FBR和传感器性能的改进，我们已经报道了释放NO 28天的传感器膜将延长到至少两个月，通过使用多孔传感器膜，释放60天以上，被动促进传感器附近的健康血管再生。通过我们的工作，我们将研究 NO释放和孔隙率对组织生物相容性和传感器性能的影响是糖尿病的函数。在这在这方面，我们将产生关于糖尿病如何影响组织整合和体内传感器的新知识。性能

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility.

DOI：
10.1021/acs.analchem.6b04251
发表时间：
2017-01-03
期刊：
Analytical chemistry
影响因子：
7.4
作者：
Soto RJ;Hall JR;Brown MD;Taylor JB;Schoenfisch MH
通讯作者：
Schoenfisch MH

Influence of diabetes on the foreign body response to nitric oxide-releasing implants.

DOI：
10.1016/j.biomaterials.2017.11.044
发表时间：
2018-03
期刊：
Biomaterials
影响因子：
14
作者：
Soto RJ;Merricks EP;Bellinger DA;Nichols TC;Schoenfisch MH
通讯作者：
Schoenfisch MH

Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.

DOI：
10.1021/acsbiomaterials.2c00392
发表时间：
2022-05
期刊：
ACS biomaterials science & engineering
影响因子：
5.8
作者：
Sara E. Maloney;Christopher A. Broberg;Quincy E Grayton;Samantha L Picciotti;Hannah R Hall;S. Wallet;R. Maile;M. Schoenfisch
通讯作者：
Sara E. Maloney;Christopher A. Broberg;Quincy E Grayton;Samantha L Picciotti;Hannah R Hall;S. Wallet;R. Maile;M. Schoenfisch

Design Considerations for Silica-Particle-Doped Nitric-Oxide-Releasing Polyurethane Glucose Biosensor Membranes.