Nitric oxide-releasing dendrimers for the treatment of periodontal disease
释放一氧化氮的树枝状聚合物用于治疗牙周病
基本信息
- 批准号:8927301
- 负责人:
- 金额:$ 34.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-02 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAerobicAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-inflammatoryAntibioticsAwarenessBacteriaCaliberCardiovascular DiseasesCaringCellsCharacteristicsChargeChemicalsCystic FibrosisDendrimersDental CareDental PlaqueDiabetic Foot UlcerDiffusionEpidemicExpenditureForeign BodiesGenerationsGingivaGingivitisGoalsHalf-LifeHealthHealth ExpendituresHealthcare SystemsHeart DiseasesImmune responseIn VitroInfectionInflammationKineticsLocal Anti-Infective AgentsMalignant NeoplasmsMicrobial BiofilmsModelingMolecular WeightMusNatureNitric OxideOralOral healthPenetrationPeriodontal DiseasesPeriodontal InfectionPeriodontal PocketPeriodontitisPhysiologicalPreventionPropertyResearchRisk FactorsRoleSafetyStrokeStructureSystemTestingTissuesWorkantimicrobialbactericidebasecombatcytotoxiccytotoxicitydesignin vitro Modelin vivokillingsmicrobialmicrobial communitynovel strategiesoral plaquepathogenperiodontopathogenpreventprogramspublic health relevanceresponsescaffoldsoft tissuesubcutaneoussubgingival biofilmsuccesstherapeutic development
项目摘要
DESCRIPTION (provided by applicant): The goal of this proposal is to develop nitric oxide releasing dendrimers to inhibit biofilm based periodontopathogens and associated periodontal disease. The rationale for pursuing this work is based on nitric oxide's broad spectrum antimicrobial activity, rapid diffusion through biofilms, short half-life (thus imparting local acton) and physiological role in the immune response to pathogens. The use of a macromolecular NO release scaffold enables us to maximize bactericidal activity while minimizing the cytotoxic impact on healthy oral cells and tissue. We will study the influence of dendrimer size/molecular weight, charge, exterior functionality, and NO release properties on pathogenic plaque bacteria killing. We will systematically study both dendrimer and nitric oxide penetration into in vitro models of oral plaque biofilms as a function of biofilm composition, maturity and mass. An established murine model for periodontal infection will be employed to evaluate how dendrimer composition and nitric oxide release influence inflammation, host immune response, and biofilm eradication.
描述(由申请人提供):本提案的目标是开发释放一氧化氮的树枝状聚合物,以抑制基于生物膜的牙周病原体和相关牙周疾病。进行这项工作的基本原理是基于一氧化氮的广谱抗微生物活性、通过生物膜的快速扩散、短半衰期(从而赋予局部作用)和在对病原体的免疫应答中的生理作用。使用大分子NO释放支架使我们能够最大限度地提高杀菌活性,同时最大限度地减少对健康口腔细胞和组织的细胞毒性影响。我们将研究树枝状聚合物的大小/分子量,电荷,外部功能和NO释放特性对致病菌斑细菌杀灭的影响。我们将系统地研究树枝状聚合物和一氧化氮渗透到口腔菌斑生物膜的体外模型中作为生物膜组成、成熟度和质量的函数。将采用已建立的牙周感染鼠模型来评估树枝状聚合物组合物和一氧化氮释放如何影响炎症、宿主免疫应答和生物膜根除。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mark H Schoenfisch其他文献
Mark H Schoenfisch的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mark H Schoenfisch', 18)}}的其他基金
Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease
释放一氧化氮的透明质酸疗法用于治疗牙周病
- 批准号:
10657158 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Nitric oxide-releasing glycosaminoglycans for treating complex wounds
释放一氧化氮的糖胺聚糖用于治疗复杂伤口
- 批准号:
10584269 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
10263316 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Nitric oxide-releasing dendrimers for the treatment of periodontal disease
用于治疗牙周病的释放一氧化氮的树枝状聚合物
- 批准号:
9261511 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
10418787 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
10673705 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Role of diabetes and nitric oxide release duration on analytical performance of in vivo glucose biosensors
糖尿病和一氧化氮释放持续时间对体内葡萄糖生物传感器分析性能的作用
- 批准号:
9185309 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Nitric oxide-releasing dendrimers for the treatment of periodontal disease
释放一氧化氮的树枝状聚合物用于治疗牙周病
- 批准号:
9104134 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Nitric oxide-releasing cystic fibrosis therapeutics
释放一氧化氮的囊性纤维化疗法
- 批准号:
8968231 - 财政年份:2014
- 资助金额:
$ 34.78万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Discovery Grants Program - Individual