Administrative Core

行政核心

• 批准号: 10675008
• 负责人: David A Bernlohr
• 金额: $ 72.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-02 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675008
• 关键词: Adherence; Adipose tissue; Adoption; Aging; Animals; Atlases; Bacterial Artificial Chromosomes; Basic Science; Biochemistry; Biology; Biology of Aging; Biophysics; Brain; Cell Aging; Cells; Cellular biology; Clinic; Collaborations; Common Data Element; Communication; Communities; Critical Care; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Development; Development Plans; Dimensions; Emerging Technologies; Ensure; Evaluation; Experimental Designs; Funding; Future; Gene Expression Profiling; Generations; Goals; Grant; Head; Histology; Home; Human; IACUC; Immunology; Interdisciplinary Study; International; Knowledge; Laboratories; Leadership; Lipids; Liver; Lung; Management Information Systems; Maps; Metabolic; Methods; Midwestern United States; Minnesota; Molecular Biology; Mus; Muscle; Obesity; Osteoporosis; Paper; Pathology; Phenotype; Pilot Projects; Procedures; Productivity; Protocols documentation; Readiness; Reporting; Reproducibility; Research; Research Personnel; Role; Sampling; Signal Transduction; Site; Software Tools; Technology; Testing; Tissues; Training; Training Activity; Transfer Agreement; Transgenic Mice; United States National Institutes of Health; Universities; Validation; Visualization; Visualization software; Work; analytical tool; biomarker discovery; bone; career; data exchange; data integration; data sharing; data standards; data submission; data visualization; experience; human tissue; innovation; medical schools; meetings; metadata standards; mouse model; nano-string; novel strategies; operation; oxidized lipid; pharmacologic; programs; senescence; single cell analysis; technology development; tissue mapping; tool; webinar

PROJECT SUMMARY The Administrative Core (AC) for the Midwest Murine-Tissue Mapping Center (MM-TMC) for Senescent Cells (SnCs) will be led by three PIs with synergistic expertise and extensive experience leading multidisciplinary research centers: Dr. David Bernlohr (UMN), an expert in adipose biology, lipid signaling, and more recently cellular senescence; Dr. Sundeep Khosla (Mayo), an expert in bone biology, cellular senescence, and mouse models to clear and report SnCs; and Dr. Scott Budinger (Northwestern), an expert in lung biology, single cell transcriptional profiling, and the biology of aging. The main goals of the AC are to facilitate interactions between the MM-TMC cores to maximize the TMC’s productivity, to create a seamless interface between the MM-TMC Data Analysis Core (DAC) and the SenNet Consortium Organization and Data Coordinating Center (CODCC), and to promote interactions with other human and mouse TMCs and UG3s (Technology Development Projects). The specific responsibilities of the AC are to i) coordinate and oversee the MM-TMC cores to facilitate access to murine tissues, data collection, analysis, and integration; ii) administer a pilot project program focused on developing innovative approaches to identify and characterize SnCs; iii) coordinate MM-TMC activities with those of other TMCs to enhance the rigor and reproducibility of mapping SnCs in mice and using mouse data to inform the human SnC mapping efforts.; iv) facilitate communication between the our DAC and the CODCC to ensure adherence to standard operating procedures (SOPs) and definitions of common data elements and to enable timely data submission; v) facilitate collaborations between the MM-TMC team and SenNet that will yield network-wide metrics for data generation and metadata standards, inter-TMC and TMC-UG3 collaborations and cross-training, and a cohesive plan for the development of data analysis and visualization tools for the broader scientific community. The Specific Aims of the MM-TMC AC are to: 1) Oversee and coordinate efforts of the MM-TMC to ensure that research goals and milestones are met with highest quality standards; 2) Integrate input from the MM-TMC DAC and the SenNet CODCC to develop and ensure compliance with SOPs for generating data sets that enable the development of a multi-dimensional atlas of SnCs with healthy mouse aging. 3) Oversee and coordinate the exploration and evaluation of novel approaches for detecting, deeply phenotyping, tracing, and perturbing SnCs as technologies emerge from pilot projects, UG3 projects, other TMCs, and external groups studying SnCs or building cell atlases; and 4) Coordinate the activities of MM-TMC with other TMCs to optimize research efficiency and economies of scale and scope, including contributing to the adoption and/or further development of data standards, analytic tools, data sharing/visualization/discovery tools, and multi-site studies and training. Successful execution of these aims will optimize the operations of MM-TMC, maximize our contribution to SenNet, and ensure compliance with SenNet SOPs that support rigor and reproducibility.

项目概要 中西部衰老细胞鼠组织图谱中心 (MM-TMC) 的管理核心 (AC) (SnCs) 将由三名 PI 领导，他们具有协同专业知识和领导多学科的丰富经验 研究中心：David Bernlohr 博士（UMN），脂肪生物学、脂质信号传导等方面的专家 细胞衰老； Sundeep Khosla 博士（梅奥），骨生物学、细胞衰老和小鼠专家 清除和报告 SnC 的模型； Scott Budinger 博士（西北大学），肺生物学、单细胞专家 转录谱和衰老生物学。审计委员会的主要目标是促进各方之间的互动 MM-TMC 内核可最大限度地提高 TMC 的生产力，在 MM-TMC 之间创建无缝接口 数据分析核心（DAC）和SenNet联盟组织和数据协调中心（CODCC）， 促进与其他人类和小鼠 TMC 和 UG3（技术开发项目）的互动。 AC 的具体职责是 i) 协调和监督 MM-TMC 核心以促进访问 小鼠组织、数据收集、分析和整合； ii) 管理试点项目计划，重点关注 开发创新方法来识别和表征 SnC； iii) 协调 MM-TMC 的活动 其他 TMC 的使用，以提高小鼠 SnC 绘图的严谨性和可重复性，并使用小鼠数据来提供信息 人类 SnC 绘图工作。； iv) 促进我们的 DAC 和 CODCC 之间的沟通，以确保 遵守标准操作程序 (SOP) 和通用数据元素的定义，并能够 及时提交数据； v) 促进 MM-TMC 团队和 SenNet 之间的合作，这将产生 数据生成和元数据标准、TMC 间和 TMC-UG3 协作的全网络指标 交叉培训，以及为更广泛的数据分析和可视化工具开发的连贯计划 科学界。 MM-TMC AC 的具体目标是： 1) 监督和协调各部门的工作 MM-TMC 确保研究目标和里程碑符合最高质量标准； 2) 整合输入 来自 MM-TMC DAC 和 SenNet CODCC 来制定并确保遵守 SOP 来生成 数据集能够开发具有健康小鼠衰老的 SnC 多维图谱。 3）监督 协调检测、深度表型分析、追踪、 随着试点项目、UG3 项目、其他 TMC 和外部团体的技术出现，SnC 受到干扰 研究 SnC 或构建细胞图谱； 4) 协调 MM-TMC 与其他 TMC 的活动以优化 研究效率以及规模经济和范围经济，包括促进采用和/或进一步 开发数据标准、分析工具、数据共享/可视化/发现工具和多站点研究 和培训。这些目标的成功执行将优化 MM-TMC 的运营，最大限度地提高我们的 对 SenNet 的贡献，并确保遵守支持严谨性和可重复性的 SenNet SOP。