Midwest Murine-Tissue Mapping Center (MM-TMC)
中西部鼠组织绘图中心 (MM-TMC)
基本信息
- 批准号:10675007
- 负责人:
- 金额:$ 270万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-02 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAccelerationAdipose tissueAgingAlzheimer&aposs DiseaseArchitectureAtlasesAttenuatedAwardBioinformaticsBiologicalBiological MarkersBiological ProcessBiologyBirthBrainCell AgingCellsCellular biologyChromatinClinicClinical TrialsCollaborationsCollectionCommunicationCommunitiesComplexDNA MethylationDataData AnalysesData CollectionData Coordinating CenterData DiscoveryData ScienceData SetDetectionDevelopmentDiseaseDisparateEmbryonic DevelopmentEquipmentEvolutionExcisionFAIR principlesGene ExpressionGenerationsGeneticGenomeGenomicsGoalsHumanHuman ResourcesImageImmune systemImmunologyImmunotherapyInformaticsInfrastructureInstitutionInternationalKnowledgeLabelLeadLearningLinkLiverLocationLongevityLungMapsMeasurementMeasuresMetadataMidwestern United StatesMinnesotaModelingMolecularMultiplexed Ion Beam ImagingMusMuscleOrganOrganismPathologicPathologyPharmaceutical PreparationsPhenotypePhysiologicalPhysiologyPlayProceduresProductionProteomicsQuality ControlReagentRecording of previous eventsResearchResearch PersonnelRoleStructure of parenchyma of lungTechnologyTimeTissue SampleTissuesTransgenic AnimalsTransgenic MiceTumor SuppressionUnited States National Institutes of HealthUniversitiesVisualizationVisualization softwareWild Type MouseWorkage relatedagedaging populationbiomarker identificationbrain tissuedata managementdata modelingdata sharingdigitalexperienceextracellularfrailtyimprovedinnovationmembermouse modelnano-stringnovelpharmacologicphenotypic biomarkerquality assuranceresilienceresponsesenescencesingle cell analysisskeletal tissuestressorsuccesssynergismtechnology developmenttissue mappingwound healing
项目摘要
PROJECT SUMMARY
Senescent cells (SnCs) play a causal role in aging and numerous age-related diseases. However, they also
contribute to beneficial biology such as wound healing and tissue remodeling. Both physiological and
pathological roles are linked to the secretome of SnCs and their complex interaction with the immune system,
which is thought to play an important role in clearing SnCs. Much of what has been learned about SnCs is derived
from studies in mice, where it has been clearly demonstrated that genetic or pharmacologic removal of SnCs in
aged or diseased organisms reduces frailty; improves strength, endurance, and resilience; and attenuates a
variety of age-related diseases, including Alzheimer’s. Discovering pharmacologic approaches to remove
disease-causing SnCs in humans could have a tremendous impact on our aging population. However, much
needs to be learned about SnCs to deploy such approaches safely and effectively in humans. This project aims
to establish a Tissue Mapping Center (TMC) across multiple institutions with demonstrated expertise in SnCs
and cell mapping to achieve a common goal; construction of a 4D atlas of SnCs in mouse tissues. The Midwest
Murine-TMC (MM-TMC) proposes to focus on 5 key tissues: mouse liver, adipose, lung, muscle, and brain. This
selection is based on MM-TMC’s expertise in the biology, cell biology, and immunology of these organs; lengthy
experience studying SnCs in these organs; and applying single cell and spatial technologies to study these
organs. The MM-TMC and its Administrative Core will be led by PIs with complementary expertise in organ
biology and senescence. The Biological Analysis Core will be led by three MPIs who have a long history of
collaboration around studying SnCs in aged mice and working with unique and innovative transgenic animals
that enable the production or ablation of lineage-specific SnCs. The Data Analysis Core will be led by two
bioinformaticians with expertise in single cell analysis, cell mapping, and multiplexing complex and disparate
data sets to deeply phenotype cells. Other key personnel add expertise in pathology, imaging, spatial mapping
of SnCs, tissue clearing, transgenic mice, and development of senolytics and immunotherapies to target SnCs.
A unique feature of the proposed MM-TMC is that the data collection will be done within existing cores largely at
the University of Minnesota by staff with expertise in state-of-the art spatial mapping platforms. This provides
stability in the analytical pipeline and in-place quality control and assurance mechanisms. Through systematic
and methodical study of SnCs in mouse tissues, the MM-TMC will make significant contributions informing and
validating the SenNet human atlas and will work closely with NIH, other TMCs, Technology Development
awardees, and the Consortium Organization and Data Coordinating Center to develop and adhere to standards
created by SenNet to accelerate the production of rigorous SnC tissue maps in both species.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David A Bernlohr其他文献
28 - Mitochondrial Dysfunction and Fragmentation Induced by Inflammation and Oxidative Stress Is Prevented b y SERCA2 Activation in Adipocytes
- DOI:
10.1016/j.freeradbiomed.2015.10.065 - 发表时间:
2015-10-01 - 期刊:
- 影响因子:
- 作者:
Rocio Foncea;Jovan Kuzmicic;David D Thomas;David A Bernlohr - 通讯作者:
David A Bernlohr
David A Bernlohr的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David A Bernlohr', 18)}}的其他基金
Midwest Murine-Tissue Mapping Center (MM-TMC)
中西部鼠组织绘图中心 (MM-TMC)
- 批准号:
10552986 - 财政年份:2022
- 资助金额:
$ 270万 - 项目类别:
Mitochondrial Dysfunction and Adipose Insulin Resistance
线粒体功能障碍和脂肪胰岛素抵抗
- 批准号:
8531229 - 财政年份:2010
- 资助金额:
$ 270万 - 项目类别:
Mitochondrial Dysfunction and Adipose Insulin Resistance
线粒体功能障碍和脂肪胰岛素抵抗
- 批准号:
7893525 - 财政年份:2010
- 资助金额:
$ 270万 - 项目类别:
相似海外基金
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Continuing Grant
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Research Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 270万 - 项目类别:
Continuing Grant
Radiation GRMHD with Non-Thermal Particle Acceleration: Next-Generation Models of Black Hole Accretion Flows and Jets
具有非热粒子加速的辐射 GRMHD:黑洞吸积流和喷流的下一代模型
- 批准号:
2307983 - 财政年份:2023
- 资助金额:
$ 270万 - 项目类别:
Standard Grant