Midwest Murine-Tissue Mapping Center (MM-TMC)

中西部鼠组织绘图中心 (MM-TMC)

基本信息

  • 批准号:
    10675007
  • 负责人:
  • 金额:
    $ 270万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-02 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Senescent cells (SnCs) play a causal role in aging and numerous age-related diseases. However, they also contribute to beneficial biology such as wound healing and tissue remodeling. Both physiological and pathological roles are linked to the secretome of SnCs and their complex interaction with the immune system, which is thought to play an important role in clearing SnCs. Much of what has been learned about SnCs is derived from studies in mice, where it has been clearly demonstrated that genetic or pharmacologic removal of SnCs in aged or diseased organisms reduces frailty; improves strength, endurance, and resilience; and attenuates a variety of age-related diseases, including Alzheimer’s. Discovering pharmacologic approaches to remove disease-causing SnCs in humans could have a tremendous impact on our aging population. However, much needs to be learned about SnCs to deploy such approaches safely and effectively in humans. This project aims to establish a Tissue Mapping Center (TMC) across multiple institutions with demonstrated expertise in SnCs and cell mapping to achieve a common goal; construction of a 4D atlas of SnCs in mouse tissues. The Midwest Murine-TMC (MM-TMC) proposes to focus on 5 key tissues: mouse liver, adipose, lung, muscle, and brain. This selection is based on MM-TMC’s expertise in the biology, cell biology, and immunology of these organs; lengthy experience studying SnCs in these organs; and applying single cell and spatial technologies to study these organs. The MM-TMC and its Administrative Core will be led by PIs with complementary expertise in organ biology and senescence. The Biological Analysis Core will be led by three MPIs who have a long history of collaboration around studying SnCs in aged mice and working with unique and innovative transgenic animals that enable the production or ablation of lineage-specific SnCs. The Data Analysis Core will be led by two bioinformaticians with expertise in single cell analysis, cell mapping, and multiplexing complex and disparate data sets to deeply phenotype cells. Other key personnel add expertise in pathology, imaging, spatial mapping of SnCs, tissue clearing, transgenic mice, and development of senolytics and immunotherapies to target SnCs. A unique feature of the proposed MM-TMC is that the data collection will be done within existing cores largely at the University of Minnesota by staff with expertise in state-of-the art spatial mapping platforms. This provides stability in the analytical pipeline and in-place quality control and assurance mechanisms. Through systematic and methodical study of SnCs in mouse tissues, the MM-TMC will make significant contributions informing and validating the SenNet human atlas and will work closely with NIH, other TMCs, Technology Development awardees, and the Consortium Organization and Data Coordinating Center to develop and adhere to standards created by SenNet to accelerate the production of rigorous SnC tissue maps in both species.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David A Bernlohr其他文献

28 - Mitochondrial Dysfunction and Fragmentation Induced by Inflammation and Oxidative Stress Is Prevented b y SERCA2 Activation in Adipocytes
  • DOI:
    10.1016/j.freeradbiomed.2015.10.065
  • 发表时间:
    2015-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rocio Foncea;Jovan Kuzmicic;David D Thomas;David A Bernlohr
  • 通讯作者:
    David A Bernlohr

David A Bernlohr的其他文献

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{{ truncateString('David A Bernlohr', 18)}}的其他基金

Midwest Murine-Tissue Mapping Center (MM-TMC)
中西部鼠组织绘图中心 (MM-TMC)
  • 批准号:
    10552986
  • 财政年份:
    2022
  • 资助金额:
    $ 270万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10675008
  • 财政年份:
    2022
  • 资助金额:
    $ 270万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10552987
  • 财政年份:
    2022
  • 资助金额:
    $ 270万
  • 项目类别:
Inflammation, Lipid Metabolism and Senescence
炎症、脂质代谢和衰老
  • 批准号:
    10264042
  • 财政年份:
    2020
  • 资助金额:
    $ 270万
  • 项目类别:
Inflammation, Lipid Metabolism and Senescence
炎症、脂质代谢和衰老
  • 批准号:
    10661613
  • 财政年份:
    2020
  • 资助金额:
    $ 270万
  • 项目类别:
Inflammation, Lipid Metabolism and Senescence
炎症、脂质代谢和衰老
  • 批准号:
    10432085
  • 财政年份:
    2020
  • 资助金额:
    $ 270万
  • 项目类别:
Inflammation, Lipid Metabolism and Senescence
炎症、脂质代谢和衰老
  • 批准号:
    10094457
  • 财政年份:
    2020
  • 资助金额:
    $ 270万
  • 项目类别:
Molecular and Cellular Basis of Obesity Core
肥胖核心的分子和细胞基础
  • 批准号:
    8132707
  • 财政年份:
    2011
  • 资助金额:
    $ 270万
  • 项目类别:
Mitochondrial Dysfunction and Adipose Insulin Resistance
线粒体功能障碍和脂肪胰岛素抵抗
  • 批准号:
    8531229
  • 财政年份:
    2010
  • 资助金额:
    $ 270万
  • 项目类别:
Mitochondrial Dysfunction and Adipose Insulin Resistance
线粒体功能障碍和脂肪胰岛素抵抗
  • 批准号:
    7893525
  • 财政年份:
    2010
  • 资助金额:
    $ 270万
  • 项目类别:

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