Molecular and Cellular Basis of Obesity Core

肥胖核心的分子和细胞基础

• 批准号: 8132707
• 负责人: David A Bernlohr
• 金额: $ 28.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132707
• 关键词: Address; Adipocytes; Adipose tissue; Affect; Animal Model; Animals; Award; Biochemistry; Biology; Biophysics; Cell Line; Cells; Collaborations; Communities; Development; Diabetes Mellitus; Doctor of Philosophy; Energy Metabolism; Fatty Acids; Fostering; Future; Gene Expression; Gene Proteins; Genes; Genome; Genomics; Head; Human; Indirect Calorimetry; Individual; Inflammation; Insulin; Journals; Knock-out; Lentivirus Vector; Link; Lipids; Liver; Mentors; Metabolic; Metabolism; Methodology; MicroRNAs; Minnesota; Mitochondria; Molecular; Molecular Biology; Obesity; Obesity associated disease; Oxidative Stress; Pancreas; Peripheral; Phenotype; Physical activity; Physiology; Process; Production; Proteins; Proteome; Proteomics; Reporting; Research; Research Personnel; Research Project Grants; Role; Sampling; Science; Services; Signal Transduction; Skeletal Muscle; Structure of nucleus infundibularis hypothalami; Study Section; Systems Biology; Technology; Time; Transgenic Organisms; United States National Institutes of Health; Universities; Viral Vector; Work; base; body system; career; editorial; experience; fatty acid-binding proteins; gain of function; interest; macrophage; meetings; member; metabolomics; professor; protein metabolite; translational study; working group

The Molecular and Cellular Basis for Obesity Core is a broadly based research and technology center that emphasizes the genes, proteins and metabolites linked to obesity and obesity-related disease. Dr. David Bernlohr, PhD, is the Core Director. Dr. Bernlohr is Professor and Head of the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota. He is the recipient of a Distinguished McKnight University Professorship and holds the Cargill Chair in Systems Biology of Human Metabolism. Dr. Bernlohr has served the scientific community in a number of capacities. He has served on the editorial boards for the Journal of Biological Chemistry, Protein Science and the Journal of Lipid Research. He finished his second term as a permanent member ofthe Integrated Physiology of Obesity and Diabetes (IPOD) Study Section and was (ihair of IPOD from 2008-2009. Dr. Bernlohr holds multiple NIH awards and has studied adipose biology his entire professional career. His primary research themes involve the role of fatty acid binding proteins and fatty acid transporters in adipocyte and macrophage metabolism, oxidative stress and mitochondrial metabolism and the role of inflammation in obesity. He uses a combination of genomic, proteomic and metabolomic methodologies in his studies and uses a variety of cell based and animal models (knockout and transgenic) in his work. He is ideally suited to be Core Director for his experimental expertise utilizes all the Core technologies and he is able to address questions plus serve as a mentor for others interested in basic obesity research. Dr. Bernlohr will devote 5% of his effort to directing the Core and will be responsible for: ¿ Overseeing all budgetary and scientific activities of the Core ¿ Representing the Core on the Center Executive Committee ¿ Preparing all Core reports and providing information on Core activities to the Center Director ¿ Evaluating Core usage and needs and planning for future development ¿ Organizing the Core Research Club ¿ Assisting in the oversight of the Gene Expression and Analysis Subcore, especially with regard to development and use of lentiviral vectors. The Core will be organized into three primary subcores with each one having a subcore leader:

肥胖核心的分子和细胞基础是一个广泛的研究和技术中心，强调与肥胖和肥胖相关疾病相关的基因，蛋白质和代谢物。David Bernlohr博士是核心主任。他是明尼苏达大学生物化学、分子生物学和生物物理系的教授和系主任。他是杰出麦克奈特大学教授的获得者，并担任嘉吉人体代谢系统生物学的主席。博士。