Molecular and Cellular Basis of Obesity Core

肥胖核心的分子和细胞基础

• 批准号: 8132707
• 负责人: David A Bernlohr
• 金额: $ 28.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132707
• 关键词: Address; Adipocytes; Adipose tissue; Affect; Animal Model; Animals; Award; Biochemistry; Biology; Biophysics; Cell Line; Cells; Collaborations; Communities; Development; Diabetes Mellitus; Doctor of Philosophy; Energy Metabolism; Fatty Acids; Fostering; Future; Gene Expression; Gene Proteins; Genes; Genome; Genomics; Head; Human; Indirect Calorimetry; Individual; Inflammation; Insulin; Journals; Knock-out; Lentivirus Vector; Link; Lipids; Liver; Mentors; Metabolic; Metabolism; Methodology; MicroRNAs; Minnesota; Mitochondria; Molecular; Molecular Biology; Obesity; Obesity associated disease; Oxidative Stress; Pancreas; Peripheral; Phenotype; Physical activity; Physiology; Process; Production; Proteins; Proteome; Proteomics; Reporting; Research; Research Personnel; Research Project Grants; Role; Sampling; Science; Services; Signal Transduction; Skeletal Muscle; Structure of nucleus infundibularis hypothalami; Study Section; Systems Biology; Technology; Time; Transgenic Organisms; United States National Institutes of Health; Universities; Viral Vector; Work; base; body system; career; editorial; experience; fatty acid-binding proteins; gain of function; interest; macrophage; meetings; member; metabolomics; professor; protein metabolite; translational study; working group

The Molecular and Cellular Basis for Obesity Core is a broadly based research and technology center that emphasizes the genes, proteins and metabolites linked to obesity and obesity-related disease. Dr. David Bernlohr, PhD, is the Core Director. Dr. Bernlohr is Professor and Head of the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota. He is the recipient of a Distinguished McKnight University Professorship and holds the Cargill Chair in Systems Biology of Human Metabolism. Dr. Bernlohr has served the scientific community in a number of capacities. He has served on the editorial boards for the Journal of Biological Chemistry, Protein Science and the Journal of Lipid Research. He finished his second term as a permanent member ofthe Integrated Physiology of Obesity and Diabetes (IPOD) Study Section and was (ihair of IPOD from 2008-2009. Dr. Bernlohr holds multiple NIH awards and has studied adipose biology his entire professional career. His primary research themes involve the role of fatty acid binding proteins and fatty acid transporters in adipocyte and macrophage metabolism, oxidative stress and mitochondrial metabolism and the role of inflammation in obesity. He uses a combination of genomic, proteomic and metabolomic methodologies in his studies and uses a variety of cell based and animal models (knockout and transgenic) in his work. He is ideally suited to be Core Director for his experimental expertise utilizes all the Core technologies and he is able to address questions plus serve as a mentor for others interested in basic obesity research. Dr. Bernlohr will devote 5% of his effort to directing the Core and will be responsible for: ¿ Overseeing all budgetary and scientific activities of the Core ¿ Representing the Core on the Center Executive Committee ¿ Preparing all Core reports and providing information on Core activities to the Center Director ¿ Evaluating Core usage and needs and planning for future development ¿ Organizing the Core Research Club ¿ Assisting in the oversight of the Gene Expression and Analysis Subcore, especially with regard to development and use of lentiviral vectors. The Core will be organized into three primary subcores with each one having a subcore leader:

肥胖核心的分子和细胞基础是一个基础广泛的研究和技术中心，强调与肥胖和肥胖相关疾病有关的基因，蛋白质和代谢物。大卫伯恩洛尔博士是核心总监。Bernlohr博士是明尼苏达大学生物化学、分子生物学和生物物理学系的教授和主任。他是杰出的麦克奈特大学教授的获得者，并拥有人体代谢系统生物学的嘉吉主席。博士 Bernlohr以多种身份为科学界服务。他曾担任《生物化学杂志》、《蛋白质科学》和《脂质研究杂志》的编委。他完成了他作为肥胖和糖尿病综合生理学（IPOD）研究部门永久成员的第二个任期，并在2008 - 2009年担任IPOD的负责人。Bernlohr博士拥有多个NIH奖项，并在整个职业生涯中研究脂肪生物学。他的主要研究主题涉及脂肪酸的作用 结合蛋白和脂肪酸转运蛋白在脂肪细胞和巨噬细胞代谢中的作用，氧化应激和线粒体代谢以及炎症在肥胖中的作用。他在研究中使用了基因组学、蛋白质组学和代谢组学方法的组合，并在工作中使用了各种基于细胞和动物模型（敲除和转基因）。他非常适合担任核心总监，因为他的实验专业知识利用了所有的核心技术，他能够解决问题，并担任其他人的导师 对基础肥胖研究感兴趣 博士Bernlohr将投入5%的精力来指导核心，并将负责： 监督核心的所有预算和科学活动 在中心执行委员会中代表核心 准备所有核心报告，并向中心主任提供核心活动的信息 评估核心的使用和需求，并规划未来的发展 核心研究俱乐部（Core Research Club） 协助监督基因表达和分析子核心，特别是关于慢病毒载体的开发和使用。 核心将被组织成三个主要的子核心，每个子核心都有一个子核心领导者：