Translational Research Technologies Core

北方新英格兰地区是美国最偏远的地区之一。 在生物医学研究的互补专业知识，谁把合作团队科学的优先事项， 翻译研究然而，一个挑战是获得最先进和快速的综合服务的机会有限。 推进研究资源、教育和技术。NNE-CTR现在提供创新和 在伙伴机构综合共享技术资源，以具有成本效益的方式支持各种方法， 教育和培训，以便研究者和学员在学术医疗中心、实践中最佳使用- 基于研究网络（PBRN）和整个地区的行业。我们巩固了战略核心 利用基因组学/表观基因组学、蛋白质组学、脂质组学和成像技术的专业知识， 重点是分子诊断/精准医学。在我们成功的基础上， 转化研究和技术核心（TRTC）为研究者提供研究支持 基于基因组学、蛋白质组学、脂质组学、细胞和组织分析、分子诊断学和新型小鼠 用于临床前研究的模型。我们的第二个目标是促进科学家之间的合作伙伴关系， 行为学家和医生调查员，以促进发现和支持职业发展， 生物医学研究人员强调多样性，公平和包容性。与社区协调 参与和外联核心，TRTC将扩大教育工作，以促进双向 交流，促进转化和临床研究中的合作和发现。本研究 基础设施，扩大教师在翻译和临床研究的发展，也将加强 与NNE-PBRN和其他临床研究者的互动和参与，以支持机制和 癌症、心血管疾病、药物滥用和其他疾病的临床调查， 北方新英格兰农村人口。此外，TRTC将建立在已建立的IDEA网络的基础上， 生物医学研究卓越（INBRE）计划和多个生物医学研究卓越中心 （COBRE），以有效地利用这些方案建立的资源， 成立调查员。TRTC对该地区的一个独特的重要影响体现在其 为快速可靠的新型冠状病毒检测提供无与伦比的支持，使用PCR分析的单步制备。它 目前还支持开发基于基因组和细胞成像的诊断， 公共卫生挑战。TRTC还将支持卫生部在伙伴州的举措， 私营部门的努力，可能需要分子诊断。总之，TRTC通过整合 独特和必要的生物医学研究专业知识、技术和服务将促进研究 能力，证书研究计划，并提高该地区调查人员的竞争力， 北方新英格兰机构及其所服务的人民的利益。

The Northern New England region is among the most rural in the U.S. It has competent investigators with complementary expertise in biomedical research, who place a priority on collaborative team science and translational research. However, one challenge is limited access to consolidated state-of-the-art and rapidly advancing research resources, education, and technologies. The NNE-CTR now provides innovative and integrated shared technical resources at partner institutions to cost-effectively support approaches with education and training for optimal use by investigators and trainees in academic medical centers, practice- based research networks (PBRNs), and industry throughout the region. We have consolidated strategic core facilities by leveraging expertise in genomic/epigenomic, proteomic, lipidomic, and imaging technologies with emphasis towards molecular diagnostics/precision medicine. Building upon our success, the goals of the Translational Research and Technologies Core (TRTC) are to provide investigators with support for research based on genomics, proteomics, lipidomics, cell and tissue analyses, molecular diagnostics and novel mouse models for preclinical studies. Our secondary goal is to advance collaborative partnerships among scientists, behaviorists, and physician investigators to foster discoveries and support the career development of biomedical researchers with an emphasis on diversity, equity, and inclusion. Coordinating with the Community Engagement and Outreach Core, the TRTC will expand educational efforts to facilitate bidirectional communication and to foster collaborations and discovery in translational and clinical research. This research infrastructure, with expanded faculty development in translational and clinical research, will also strengthen the interactions and engagement with the NNE-PBRN and other clinician investigators to support mechanistic and clinical investigations of cancer, cardiovascular disease, substance abuse and other diseases prevalent in the northern New England rural population. Furthermore, the TRTC will build upon established IDeA Networks of Biomedical Research Excellence (INBRE) programs and multiple Centers of Biomedical Research Excellence (COBRE), to effectively leverage resources established by these programs for the enhancement of young and established investigators. A singular important impact of the TRTC to the region was exemplified by its unparalleled support for rapid and reliable Covid-19 testing using a single-step preparation for PCR analysis. It is also currently supporting the development of genomic and cellular imaging-based diagnostics for future public health challenges. TRTC will also support Department of Health initiatives in partnering states and private sector endeavors that likely will require molecular diagnostics. In summary, the TRTC, by integrating unique and essential biomedical research expertise, technologies, and services, will enhance research capacity, credential research programs, and increase the competitiveness of investigators in the region for the benefit of northern New England institutions and the people they serve.