Translational Research Technologies Core

转化研究技术核心

• 批准号: 10505154
• 负责人: Frances E. Carr
• 金额: $ 54.15万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-03 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505154
• 关键词: Academic Medical Centers; Archives; Biological; Biomedical Research; COVID-19 testing; Cardiovascular Diseases; Cells; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Communication; Community Outreach; Complex; Computer Models; Core Facility; Data; Data Collection; Development; Diagnostic; Disease; Education; Education and Outreach; Emerging Technologies; Environment; Experimental Designs; Fostering; Funding; Future; Genomics; Glare; Goals; Health; Imaging technology; Industry; Informatics; Information Systems; Infrastructure; Institution; Leadership; Malignant Neoplasms; Mentors; Methods; Mission; Modeling; New England; Persons; Phenotype; Physicians; Play; Preparation; Price; Private Sector; Process; Proteomics; Public Health; Reproducibility of Results; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Rural; Rural Population; Science; Scientist; Secure; Sensitivity and Specificity; Services; Substance abuse problem; Systems Biology; Teacher Professional Development; Technology; Tissues; Training; Training and Education; Translating; Translational Research; United States National Institutes of Health; base; career development; cellular imaging; clinical investigation; community engagement; cost; data management; design; diversity and equity; epidemiology study; epigenomics; health care delivery; healthcare community; innovation; innovative technologies; instrumentation; interdisciplinary collaboration; lipidomics; meetings; molecular diagnostics; mouse model; multiple data types; multiple omics; new technology; novel; novel strategies; outreach; practice-based research network; precision medicine; preclinical study; programs; statistics; success; transcriptomics; translational goal; translational impact; virtual; webinar

The Northern New England region is among the most rural in the U.S. It has competent investigators with complementary expertise in biomedical research, who place a priority on collaborative team science and translational research. However, one challenge is limited access to consolidated state-of-the-art and rapidly advancing research resources, education, and technologies. The NNE-CTR now provides innovative and integrated shared technical resources at partner institutions to cost-effectively support approaches with education and training for optimal use by investigators and trainees in academic medical centers, practice- based research networks (PBRNs), and industry throughout the region. We have consolidated strategic core facilities by leveraging expertise in genomic/epigenomic, proteomic, lipidomic, and imaging technologies with emphasis towards molecular diagnostics/precision medicine. Building upon our success, the goals of the Translational Research and Technologies Core (TRTC) are to provide investigators with support for research based on genomics, proteomics, lipidomics, cell and tissue analyses, molecular diagnostics and novel mouse models for preclinical studies. Our secondary goal is to advance collaborative partnerships among scientists, behaviorists, and physician investigators to foster discoveries and support the career development of biomedical researchers with an emphasis on diversity, equity, and inclusion. Coordinating with the Community Engagement and Outreach Core, the TRTC will expand educational efforts to facilitate bidirectional communication and to foster collaborations and discovery in translational and clinical research. This research infrastructure, with expanded faculty development in translational and clinical research, will also strengthen the interactions and engagement with the NNE-PBRN and other clinician investigators to support mechanistic and clinical investigations of cancer, cardiovascular disease, substance abuse and other diseases prevalent in the northern New England rural population. Furthermore, the TRTC will build upon established IDeA Networks of Biomedical Research Excellence (INBRE) programs and multiple Centers of Biomedical Research Excellence (COBRE), to effectively leverage resources established by these programs for the enhancement of young and established investigators. A singular important impact of the TRTC to the region was exemplified by its unparalleled support for rapid and reliable Covid-19 testing using a single-step preparation for PCR analysis. It is also currently supporting the development of genomic and cellular imaging-based diagnostics for future public health challenges. TRTC will also support Department of Health initiatives in partnering states and private sector endeavors that likely will require molecular diagnostics. In summary, the TRTC, by integrating unique and essential biomedical research expertise, technologies, and services, will enhance research capacity, credential research programs, and increase the competitiveness of investigators in the region for the benefit of northern New England institutions and the people they serve.

新英格兰北部地区是美国农村最严重的地区之一。该地区拥有称职的调查人员 在生物医学研究方面的互补专业知识，他们优先考虑协作团队科学和 翻译研究。然而，一个挑战是对整合的最先进和快速的访问有限 推进研究资源、教育和技术。NNE-CTR现在提供创新和 整合伙伴机构的共享技术资源，以经济高效的方式支持 为学术医学中心的研究人员和受训人员提供最佳利用的教育和培训，实践- 基于研究网络(PBRN)和整个地区的行业。我们已经巩固了战略核心 通过利用基因组/表观基因组、蛋白质组、脂组和成像技术的专业知识 强调分子诊断/精确医学。在我们成功的基础上， 翻译研究和技术核心(TRTC)是为研究人员提供研究支持 基于基因组学、蛋白质组学、脂质组学、细胞和组织分析、分子诊断和新型小鼠 临床前研究的模型。我们的次要目标是促进科学家之间的合作伙伴关系， 行为主义者和内科研究人员，以促进发现和支持职业发展 生物医学研究人员，强调多样性、公平性和包容性。与社区协调 参与和外联核心，TRTC将扩大教育努力，促进双向 交流，促进翻译和临床研究中的合作和发现。这项研究 基础设施，以及在翻译和临床研究方面扩大的师资发展，也将加强 与NNE-PBRN和其他临床医生研究人员的互动和参与，以支持机械和 癌症、心血管疾病、药物滥用等常见病的临床调查 新英格兰北部的农村人口。此外，TRTC将建立在现有的IDEA网络的基础上 生物医学卓越研究(INBRE)计划和多个生物医学研究卓越中心 (Cobre)，有效地利用这些方案建立的资源，以增强年轻人和 老牌调查员。TRTC对该区域的一个独特而重要的影响体现在其 使用聚合酶链式反应分析的一步准备，无与伦比地支持快速可靠的新冠肺炎检测。它 目前还支持未来基于基因组和细胞成像的诊断技术的发展 公共卫生挑战。TRTC还将支持卫生部在合作州和 私营部门的努力可能需要分子诊断。总而言之，TRTC通过整合 独特和基本的生物医学研究专业知识、技术和服务将促进研究 能力，证书研究计划，并增加该地区调查人员的竞争力 新英格兰北部的机构和他们所服务的人的利益。