Translational Research Technologies Core

转化研究技术核心

• 批准号: 9361854
• 负责人: Frances E. Carr
• 金额: $ 52.38万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9361854
• 关键词: Address; Affect; Archives; Awareness; Basic Science; Biological; Biomedical Research; Biomedical Technology; Cardiovascular Diseases; Cells; Centers of Research Excellence; Chronic Disease; Client; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Core Facility; Data; Data Collection; Development; Disease; Education and Outreach; Effectiveness; Emerging Technologies; Ensure; Epigenetic Process; Evaluation; Experimental Designs; Foundations; Funding; Future; Genomics; Goals; Health; Healthcare; Informatics; Institution; Investigation; Laboratories; Leadership; Maine; Malignant Neoplasms; Massive Parallel Sequencing; Measures; Medical center; Mentors; Mentorship; Mission; Monitor; New England; Online Systems; Physicians; Pilot Projects; Population; Population Study; Process; Proteomics; Recommendation; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Rural; Rural Population; Sampling; Scientist; Secure; Strategic Planning; Substance abuse problem; Surveys; Systems Biology; Teacher Professional Development; Technical Expertise; Technology; Tissues; Training; Training Programs; Training and Education; Translational Research; Universities; Vermont; Work; base; career development; clinical development; clinical investigation; cost effective; design; epidemiology study; experience; experimental study; instrumentation; meetings; member; mouse model; new technology; personalized medicine; preclinical study; programs; statistics; success; tool; translational genomics; viral vector development; web portal

PROJECT SUMMARY To address the health issues of the mostly rural northern New England population and build translational research capacity, there is a compelling need to integrate the clinical and translational research infrastructure into a network that brings together the diversity of resources and expertise of Maine Medical Center and the University of Vermont in the Northern New England Clinical and Translational Research Network (NNE-CTR). The goal of the Translational Research Technologies Core (TRTC) of the NNE-CTR is to provide coordinated access to state-of-the-art core facilities developed at the institutions through a combination of COBRE, INBRE, institutional and other forms of support over the last several years. The TRTC will provide access to instrumentation, expertise and other resources crucial to the success of clinical and translational research by NNE-CTR investigators. These resources include infrastructure and technical expertise for genomic, epigenetic, proteomic, cell and tissue analyses and clinical and translational genomics. In addition to providing infrastructure, instrumentation and expertise, the TRTC will provide education and training to investigators about current and emerging technologies that will be essential to the success of their research activities. The TRTC will coordinate all of these activities through a web-based portal that will serve to integrate all of these resources, thus creating a single point of entry for accessing core resources at NNE-CTR partner institutions. To accomplish these goals we propose three specific aims. In Aim 1 we will establish the infrastructure necessary to coordinate access to NNE-CTR core facilities. A robust, highly functional web-portal will be an enabling step towards this goal. In Aim 2, the TRTC will develop, in collaboration with the Professional Development and Pilot Projects Program Cores, outreach and education programs to enhance awareness, understanding and use of advanced biomedical technologies. In Aim 3, the TRTC will work with the Tracking and Evaluation and Administrative Cores to develop evaluation tools to measure the use of core facilities and their effectiveness in advancing clinical and translational research in NNE-CTR as well as to determine the future infrastructure needs of NNE-CTR investigators. By increasing the capacity for clinical and translational investigations through enhanced access to biomedical technologies, new discoveries will be made that will directly benefit not only the health care needs of the rural northern New England population, but that of the nation.

项目摘要 为了解决北方新英格兰大部分农村人口的健康问题， 研究能力，迫切需要整合临床和转化研究基础设施 将缅因州医疗中心的各种资源和专业知识汇集在一起， 佛蒙特大学北方新英格兰临床和转化研究网络（NNE-CTR）。 NNE-CTR的转化研究技术核心（TRTC）的目标是提供协调的 通过COBRE，INBRE， 在过去几年里，我们得到了机构和其他形式的支持。TRTC将提供访问 仪器，专业知识和其他资源对临床和转化研究的成功至关重要， NNE-CTR研究者。这些资源包括基因组学的基础设施和技术专长， 表观遗传学、蛋白质组学、细胞和组织分析以及临床和翻译基因组学。除了提供 在基础设施、仪器和专业知识方面，TRTC将为研究人员提供教育和培训 关于当前和新兴的技术，将是他们的研究活动的成功至关重要。的 TRTC将通过一个基于网络的门户网站协调所有这些活动，该门户网站将有助于整合所有这些活动。 因此，为获得NNE-CTR伙伴机构的核心资源创造了一个单一的入口点。 为了实现这些目标，我们提出了三个具体目标。目标1：建立基础设施 协调NNE-CTR核心设施的使用。一个强大的、功能强大的门户网站将是一个 为实现这一目标迈出了一步。在目标2中，TRTC将与专业人员合作， 发展和试点项目方案核心、外联和教育方案，以提高认识， 了解和使用先进的生物医学技术。在目标3中，TRTC将与跟踪 以及评价和行政核心，以开发评价工具，衡量核心设施的使用情况， 他们在推进NNE-CTR的临床和转化研究方面的有效性，以及确定 NNE-CTR研究者未来的基础设施需求。通过提高临床和翻译能力， 通过加强对生物医学技术的利用，将有新的发现， 不仅直接受益于北方新英格兰农村人口的医疗保健需求， 民族