Animal Shared Resource

动物共享资源--项目摘要/摘要 动物共享资源通过提供高质量的服务为CSHL癌症中心成员提供完整的支持 动物住房、畜牧业服务以及技术和管理支持。此外，训练有素的 技术人员提供高级服务以及各种方法和技能的培训，包括：外科手术 操作，术后监测，血液和组织采集，组织灌流，以及治疗和 病毒管理。动物共享资源由系主任艾莉亚·米尔斯博士和主任雷切尔领导 由动物共享资源提供的支持对许多研究进展至关重要 CSHL癌症中心。它使研究人员能够开发出癌症的创新动物模型， 继续在揭示疾病的遗传和分子基础方面发挥重要作用。其中包括病毒 转导模型、多等位基因可逆性肿瘤模型和有机类化合物原位移植模型 人类和老鼠的癌症。随着CSHL癌症中心转移到扩大其临床前和翻译 研究，动物模型将变得更加迫切。动物共享资源为研究人员提供 有能力超越细胞培养，探索适当的癌症生物学和癌症医学 在活体环境中。总之，动物共享资源为癌症中心提供了一套完整的 基本服务和先进的技术支持，以促进癌症研究和发现。在当前 在此期间，23个癌症中心成员实验室(61%的成员)使用了动物共享资源， 包括所有三个项目的调查人员。这一共享资源促成了癌症组织的58份出版物 此时间段内的中心成员。

ANIMAL SHARED RESOURCE - PROJECT SUMMARY/ABSTRACT The Animal Shared Resource offers integral support to CSHL Cancer Center members by providing high quality animal housing, husbandry services, and technical and managerial support. In addition, highly trained technicians offer advanced services as well as training on a variety of methods and skills, including: surgical manipulations, post-surgery monitoring, blood and tissue procurement, tissue perfusion, and therapeutic and virus administration. The Animal Shared Resource is led by Faculty Head Alea Mills, Ph.D. and Director Rachel Rubino, D.V.M. The support provided by the Animal Shared Resource is critical for many research advances in the CSHL Cancer Center. It has enabled researchers to develop innovative animal models for cancer, which continue to be instrumental in uncovering the genetic and molecular basis of the disease. These include viral transduction models, multi-allele reversible cancer models, and organoid orthotopic engraftment models of human and mouse cancer. As the CSHL Cancer Center shifts to expand its preclinical and translational research, animal models will become even more imperative. The Animal Shared Resource provides researchers with the ability to move beyond cell culture and to explore cancer biology and cancer medicine in an appropriate in vivo context. In summary, the Animal Shared Resource provides the Cancer Center with a complete set of essential services and sophisticated technical support to facilitate cancer research and discovery. In the current period, the Animal Shared Resource was used by 23 Cancer Center member laboratories (61% of members), including investigators from all three Programs. This Shared Resource contributed to 58 publications by Cancer Center members over this time period.