Animal Shared Resource

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ANIMAL SHARED RESOURCE - PROJECT SUMMARY/ABSTRACT The Animal Shared Resource offers integral support to CSHL Cancer Center members by providing high quality animal housing, husbandry services, and technical and managerial support. In addition, highly trained technicians offer advanced services as well as training on a variety of methods and skills, including: surgical manipulations, post-surgery monitoring, blood and tissue procurement, tissue perfusion, and therapeutic and virus administration. The Animal Shared Resource is led by Faculty Head Alea Mills, Ph.D. and Director Rachel Rubino, D.V.M. The support provided by the Animal Shared Resource is critical for many research advances in the CSHL Cancer Center. It has enabled researchers to develop innovative animal models for cancer, which continue to be instrumental in uncovering the genetic and molecular basis of the disease. These include viral transduction models, multi-allele reversible cancer models, and organoid orthotopic engraftment models of human and mouse cancer. As the CSHL Cancer Center shifts to expand its preclinical and translational research, animal models will become even more imperative. The Animal Shared Resource provides researchers with the ability to move beyond cell culture and to explore cancer biology and cancer medicine in an appropriate in vivo context. In summary, the Animal Shared Resource provides the Cancer Center with a complete set of essential services and sophisticated technical support to facilitate cancer research and discovery. In the current period, the Animal Shared Resource was used by 23 Cancer Center member laboratories (61% of members), including investigators from all three Programs. This Shared Resource contributed to 58 publications by Cancer Center members over this time period.