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Functional Characterization of Children with Chronic Venous Thromboembolic Disease

慢性静脉血栓栓塞性疾病儿童的功能特征

基本信息

批准号：
10674002
负责人：
Ayesha Zia
金额：
$ 68.33万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10674002
关键词：
3-Dimensional Accelerometer Activities of Daily Living Adherence Adult Aerobic Exercise Affect Affective Anticoagulation Bioenergetics Blood Vessels Blood coagulation Body Weight decreased Body mass index Breathing Cardiac Cardiology Cardiovascular system Child Childhood Chronic Clinical Clinical Treatment Coupling Data Deep Vein Thrombosis Diagnosis Disease Distress Dyspnea Echocardiography Exercise Exertion Fatigue Feeling Functional disorder Future Goals Hematology Hospitalized Child Impairment Incentives Incidence Intervention K-Series Research Career Programs Leg Limb structure Lower Extremity Lung Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurement Measures Metabolic Muscle National Heart, Lung, and Blood Institute Obesity Obstruction Outcome Patients Perfusion Peripheral Phosphocreatine Physical activity Physiological Physiology Play Postphlebitic Syndrome Prospective, cohort study Pulmonary Circulation Pulmonary Embolism Pulmonary artery structure Quality of life Recovery Recurrence Research Resolution Respiratory Mechanics Rest Right Ventricular Dysfunction Right ventricular structure Risk Factors Secondary to Sensory Shortness of Breath Site Skeletal Muscle Symptoms Syndrome Testing Thinking Thrombosis Thrombus Translational Research Venous Venous Thrombosis Ventricular Work adverse outcome cardiac magnetic resonance imaging clinically relevant clinically significant cohort common symptom deconditioning design disability emotional distress exercise capacity exercise intolerance exercise training experience fitness hemodynamics imaging science improved in vivo novel pediatric patients prevent sedentary skeletal muscle metabolism thromboinflammation venous thromboembolism ventilation young adult

项目摘要

PROJECT SUMMARY Venous thrombosis affects approximately 1 in 200 hospitalized children. Important symptoms after deep venous thrombosis (DVT) involving lower extremities and pulmonary embolism (PE) include shortness of breath and exercise intolerance resulting in a decreased quality of life. The mechanisms of these symptoms are unknown. Although patients with venous thrombosis with excise intolerance and exertional dyspnea are generally considered to be deconditioned, our preliminary data challenge this conventional wisdom. Thus, it is presently unclear if exercise intolerance or exertional dyspnea are due to cardiovascular, pulmonary, or limb- muscle dysfunction and whether acquired risk-factors such as deconditioning or obesity contribute to these problems. If we find evidence of deconditioning causing or complicating exercise intolerance or dyspnea, exercise training would be dramatically beneficial; for obesity-related changes in respiratory mechanics, aggressive weight loss measures may be necessary before exercise training can be tolerated. In this application, we will utilize state-of-the-art measures, including 7 Tesla magnetic resonance imaging, at rest and during exercise to investigate central and peripheral mechanisms of these common symptoms. Aim 1 will characterize cardiac limitations; Aim 2, pulmonary and Aim 3, skeletal muscle metabolic aberrations following DVT and PE at 3 and 12 months post-diagnosis in pediatric patients following diagnosis. Our long-term objective is to provide novel and clinically relevant results that could potentially alter approaches for preventing and treating exercise intolerance and dyspnea and improving the quality of life for pediatric patients with VTE.

项目总结

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Practical considerations and consensus opinion for children's hospital-based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis.

儿童医院住院止血和血栓 (HAT) 咨询服务的实际考虑因素和共识意见：ISTH SSC 儿科/新生儿血栓和止血小组委员会的通讯。

DOI：
10.1111/jth.15798
发表时间：
2022
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
0
作者：
Woods,GaryM;Raffini,Leslie;Brandão,LeonardoR;Jaffray,Julie;Branchford,BrianR;Ng,ChristopherJ;Sartain,SarahE;Pak,Jennifer;Male,Christoph;Zia,Ayesha;Rizzi,Mattia;Sirachainan,Nongnuch;Faustino,EdwardVincentS;Carpenter,Shanno
通讯作者：
Carpenter,Shanno

High annualized bleeding rates in pediatric patients with inherited platelet function disorders.

患有遗传性血小板功能障碍的儿科患者的年出血率较高。

DOI：
10.3324/haematol.2024.284996
发表时间：
2024
期刊：
Haematologica
影响因子：
10.1
作者：
Saini,Shelly;Zhang,Song;Yates,Sean;Garcia,Jessica;Sharma,Ruchika;Formella,Joseph;Sarode,Ravindra;Zia,Ayesha
通讯作者：
Zia,Ayesha

Serious bleeds in pediatric persons with hemophilia A on emicizumab prophylaxis.

在预防症中，血友病A的小儿患者的严重出血。