Mayo Clinic Center for Clinical and Translational Science (CCaTS)

梅奥诊所临床和转化科学中心 (CCaTS)

• 批准号: 10674614
• 负责人: VESNA D GAROVIC
• 金额: $ 793.42万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674614
• 关键词: Acceleration; Address; Advocate; COVID-19; COVID-19 pandemic; Caring; Classification; Clinic; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Competence; Country; Education; Elements; Environment; Event; Faculty; Funding; Goals; Health; Health system; Healthcare; Human; Incubators; Individual; Informatics; Institution; Interdisciplinary Study; Investments; Justice; Knowledge; Leadership; Learning; Medical Students; Methodology; Methods; Minnesota; Mission; National Center for Advancing Translational Sciences; Patient Care; Patients; Persons; Population; Positioning Attribute; Postdoctoral Fellow; Process; Research; Research Personnel; Resources; Role; Rural Population; Scientist; Secure; Structural Racism; Talents; Technology; Training; Training and Education; Translational Research; Translations; Trust; United States National Institutes of Health; Vision; Work; base; clinical center; clinical practice; community engagement; digital; digital health; equity, diversity, and inclusion; graduate student; health care service organization; health disparity; health equity; health equity promotion; health inequalities; improved; innovation; interest; medical schools; member; multidisciplinary; novel; operation; pandemic disease; programs; response; social disparities; synergism; theories; tool; underserved community

Contact PD/PI: Lucchinetti, Claudia F. OVERALL: Project Summary/Abstract Mayo Clinic is one of the largest not‐for‐profit, academic health systems, top-ranked for quality more often than any other health care organization. It has integrated operations in 5 U.S. states, and more than 1 million people came to Mayo Clinic for care last year. Clinical and translational science (CTS) is a fundamental and highly valued element of Mayo Clinic; indeed, all research at Mayo Clinic is directed towards translation of scientific knowledge to improve patient care, with almost 60% of our NIH funding base classified as clinical research or trials. In recognition of the importance of continued advances in CTS to the Mayo Clinic mission, our institutional leadership has entrusted the Mayo Clinic Center for Clinical and Translational Sciences (CCaTS) to be the engine of translational innovation and the institutional advocate for CTS and translational research. CCaTS has served as a CTS innovation incubator for numerous efforts that were created with CCaTS funding and are now supported by the institution. The overall vision of CCaTS is to enable high-quality, team-based multidisciplinary research that accelerates clinical trial innovation, facilitates digital health transformation, and partners with our stakeholders and communities to improve patient care and health for all people. Our team- based culture has been described as one of “boundarylessness,” wherein organizational barriers are removed to enable talent, innovation, and knowledge to converge where needed. In this context and that of our longstanding commitment to patient-focused research, we are uniquely positioned to accomplish the following Specific Aims. In Aim 1, we will simplify and accelerate the work of translation to improve health for all by advancing clinical trial innovations and digital health transformations, streamlining methods and processes, and developing novel informatics solutions that increase efficiency and drive implementation of discoveries that improve health and promote health equity. In Aim 2, we will enhance our education programs through the expanded reach of competency-based, learner-focused solutions, training a diverse, inclusive, multidisciplinary CTS workforce to be prepared to address the urgent health care needs of all communities in a rapidly changing environment. In Aim 3, we will engage local community members and patients to be active partners in translational teams, expanding research capabilities of underserved communities, including rural populations. Our goal is to improve health and reduce health inequities by helping these communities realize the benefits of CTS. In Aim 4, we will expand national and regional partnerships and strengthen collaborative CTS networks in all aspects of CTS and education, focusing on sharing innovative approaches and prioritizing diversity, equity, and inclusion, with the goal of improving human health and advancing health equity. In summary, sustained investment in CCaTS will enable us to continue to meet ongoing and emergent challenges in health care for all, as exemplified by our response to support communities through the COVID-19 crisis. Project Summary/Abstract Page 289 Contact PD/PI: Lucchinetti, Claudia F.

联系PD/PI：Lucchinetti，Claudia F. 总体：项目摘要/摘要 梅奥诊所是最大的非营利性学术健康系统之一，在质量方面经常排名第一 任何其他医疗保健组织。它在美国5个州整合了业务，拥有100多万人 去年来梅奥诊所接受治疗。临床与转化科学(CTS)是一门基础和高度 梅奥诊所的重要元素；事实上，梅奥诊所的所有研究都致力于翻译科学 改善患者护理的知识，我们NIH几乎60%的资金基础被归类为临床研究或 审判。认识到继续推进CTS对梅奥诊所使命的重要性，我们的 机构领导层已委托梅奥临床和翻译科学中心(CCATS) 成为翻译创新的引擎和翻译研究和翻译研究的机构倡导者。 CCaTS已成为CTS创新孵化器，为利用CCaTS资金创建的众多努力提供支持 现在都得到了该机构的支持。CCaTS的总体愿景是实现高质量、基于团队的 多学科研究，加速临床试验创新，促进数字健康转型，以及 与我们的利益相关者和社区合作，改善所有人的患者护理和健康。我们的团队- 以文化为基础的文化被描述为“无边界文化”，即消除组织障碍 使人才、创新和知识能够在需要的地方汇聚。在这方面和我们的 长期致力于以患者为中心的研究，我们具有独特的地位来实现以下目标 明确的目标。在目标1中，我们将简化和加快翻译工作，通过以下方式改善所有人的健康 推进临床试验创新和数字健康转型，精简方法和流程， 以及开发新的信息学解决方案，以提高效率并推动以下发现的实施 改善健康，促进健康公平。在目标2，我们将通过以下方式加强我们的教育计划 扩大以能力为基础、以学习者为中心的解决方案的覆盖范围，培训多样化、包容性、多学科的 CTS工作人员做好准备，在快速变化的环境中满足所有社区的迫切医疗需求 环境。在目标3中，我们将动员当地社区成员和患者积极参与 翻译团队，扩大包括农村人口在内的服务不足社区的研究能力。 我们的目标是通过帮助这些社区实现以下好处来改善健康并减少健康不平等 CTS.在目标4中，我们将扩大国家和区域伙伴关系，加强CTS协作网络 在CTS和教育的所有方面，注重分享创新方法和优先考虑多样性， 公平和包容，以改善人类健康和促进健康公平为目标。总而言之， 对CCATS的持续投资将使我们能够继续应对卫生领域持续和紧急的挑战 关爱所有人，我们在新冠肺炎危机期间支持社区的回应就是例证。 项目摘要/摘要页289 联系PD/PI：Lucchinetti，Claudia F.

项目成果

Association Between Antifibrinolytic Therapy and Perioperative Outcomes in Patients With Coronary Artery Stents Undergoing Noncardiac Surgery.

• DOI: 10.1213/ane.0000000000005522
• 发表时间: 2021-06-01
• 期刊: Anesthesia and analgesia
• 影响因子: 5.7
• 作者: Boswell MR;Smith MM;Frank RD;Brown MJ;Abcejo AS;Kor TM;Gulati R;Smith BB
• 通讯作者: Smith BB

Machine Learning Identifies Smartwatch-Based Physiological Biomarker for Predicting Disruptive Behavior in Children: A Feasibility Study.

• DOI: 10.1089/cap.2023.0038
• 发表时间: 2023-11
• 期刊: Journal of child and adolescent psychopharmacology
• 影响因子: 1.9

Childhood psychiatric outcomes in the context of suspected neglect and abuse reports related and unrelated to parental substance use.

• DOI: 10.1016/j.chiabu.2021.105344
• 发表时间: 2021-12
• 期刊: Child abuse & neglect
• 影响因子: 4.8
• 作者: Gandhi KD;Romanowicz M;Croarkin PE;Thapa P;Limbeck M;Desai J;Benarroch AJM;Shekunov J
• 通讯作者: Shekunov J

The comparative effectiveness of decision aids in diverse populations with early stage prostate cancer: a study protocol for a cluster-randomized controlled trial in the NCI Community Oncology Research Program (NCORP), Alliance A191402CD.

• DOI: 10.1186/s12885-018-4672-3
• 发表时间: 2018-08-06
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Pacyna JE;Kim S;Yost K;Sedlacek H;Petereit D;Kaur J;Rapkin B;Grubb R;Paskett E;Chang GJ;Sloan J;Basch E;Major B;Novotny P;Taylor J;Buckner J;Parsons JK;Morris M;Tilburt JC
• 通讯作者: Tilburt JC

Topics and Sentiment Surrounding Vaping on Twitter and Reddit During the 2019 e-Cigarette and Vaping Use-Associated Lung Injury Outbreak: Comparative Study.

• DOI: 10.2196/39460
• 发表时间: 2022-12-13
• 期刊: JOURNAL OF MEDICAL INTERNET RESEARCH
• 影响因子: 7.4
• 作者: Wu, Dezhi;Kasson, Erin;Singh, Avineet Kumar;Ren, Yang;Kaiser, Nina;Huang, Ming;Cavazos-Rehg, Patricia A.
• 通讯作者: Cavazos-Rehg, Patricia A.