Hypertensive pregnancy disorders and future coronary artery disease

妊娠高血压疾病和未来冠状动脉疾病

• 批准号: 10452767
• 负责人: VESNA D GAROVIC
• 金额: $ 47.87万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452767
• 关键词: Affect; Age; Age-Years; Aging; Atherosclerosis; Atrial Fibrillation; Back; Cardiac Surgery procedures; Cardiovascular system; Caring; Cause of Death; Cessation of life; Clinical; Code; Cohort Studies; Coronary Arteriosclerosis; Coronary Artery Bypass; County; Data; Death Rate; Diagnosis; Diagnostic; Disease; Early Diagnosis; Epidemiology; Event; Female; Future; Goals; Gold; Heart failure; Hypertension; Knowledge; Lead; Medical Record Linkage; Medical Records; Menopause; Methodology; Minnesota; Morbidity - disease rate; Myocardial Infarction; Nested Case-Control Study; Onset of illness; Outcome; Patient Self-Report; Postmenopause; Pre-Eclampsia; Pregnancy; Prevalence; Prevention; Prognosis; Proteinuria; Publishing; Recording of previous events; Records; Reporting; Research; Research Design; Resources; Risk; Risk Factors; Severities; Source; Stroke; System; Taxus; Testing; Time; Treatment Efficacy; United States; Woman; Women' s Role; base; cardiovascular health; cardiovascular risk factor; clinical care; clinical practice; cohort; diagnostic strategy; disability; disorder risk; endothelial dysfunction; epidemiology study; experience; fetal; follow-up; hormone therapy; hypertensive; improved; longitudinal dataset; male; men; modifiable risk; mortality; next generation; normotensive; novel; parity; percutaneous coronary intervention; population based; pregnancy disorder; prospective; risk prediction; screening guidelines; sex; synergism; tool; treatment strategy

PROJECT SUMMARY Coronary artery disease (CAD) is the leading cause of death and disability among women in the United States. It became apparent in the 1980s that the decline of cardiovascular mortality in men was not accompanied by the same rate of decline in women. The reasons for these differences may relate to worsening of the overall CAD risk profile for aging in women compared to men, which may be further potentiated by sex-based disparities in cardiovascular care: women have been both under-evaluated for CAD and under-treated for modifiable risk factors. In addition, female sex-specific conditions, such as hypertensive pregnancy disorders (HPD), together with menopause and hormone therapy, may contribute to those differences. Approximately 6%-8% of pregnancies are affected by HPD, which remains a leading cause of both maternal and fetal morbidity and mortality worldwide. HPD cover a spectrum of conditions, most notably preeclampsia, a pregnancy-specific hypertensive disorder further characterized by systemic endothelial dysfunction and proteinuria. Our overarching hypothesis is that a history of HPD in general, and preeclampsia in particular, represents a unique risk factor that is independent of traditional risk factors for future coronary artery disease (CAD) events, including myocardial infarction, coronary artery bypass grafting and percutaneous coronary intervention (Aim 1); is associated with more severe atherosclerotic disease at CAD event (Aim 2); and is related to increasing cardiovascular morbidity and death among women with CAD (Aim 3). There are no studies to date of the association between a history of HPD/preeclampsia and CAD that confirm both exposure and outcome based on accepted clinical criteria, and that stratify the outcome based on the severity of exposure while controlling for known risk factors occurring before, during, and after the affected pregnancies. This proposal will cover current gaps in knowledge by testing these associations using the unique population-based records-linkage system of the Rochester Epidemiology Project (REP). We will include all female residents of Olmsted County, Minnesota who were identified through existing cohorts and REP-based sources, and who had an incident CAD event from 2002-2017, supplemented with cohorts of incident heart failure and atrial fibrillation that will be used to ascertain subsequent cardiovascular outcomes. We will perform extensive medical record reviews to confirm the diagnoses of HPD by using validated criteria for the retrospective diagnoses of HPD. The results of the proposed research may open new venues for early detection, prevention, diagnosis, and treatment of CAD in women.

项目总结

项目成果

How accurate are citations of frequently cited papers in biomedical literature?

• DOI: 10.1042/cs20201573
• 发表时间: 2021-03-12
• 期刊: Clinical science (London, England : 1979)
• 作者: Pavlovic V;Weissgerber T;Stanisavljevic D;Pekmezovic T;Milicevic O;Lazovic JM;Cirkovic A;Savic M;Rajovic N;Piperac P;Djuric N;Madzarevic P;Dimitrijevic A;Randjelovic S;Nestorovic E;Akinyombo R;Pavlovic A;Ghamrawi R;Garovic V;Milic N
• 通讯作者: Milic N

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association.

• DOI: 10.1161/hyp.0000000000000208
• 发表时间: 2022-03
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Garovic, Vesna D.;Dechend, Ralf;Easterling, Thomas;Karumanchi, Ananth;Baird, Suzanne McMurtry;Magee, Laura A.;Rana, Sarosh;Vermunt, Jane V.;August, Phyllis;Chair, Vice
• 通讯作者: Chair, Vice

Risk of Adult Hypertension in Offspring From Pregnancies Complicated by Hypertension: Population-Based Estimates.

妊娠并发高血压的后代患成人高血压的风险：基于人群的估计。

• DOI: 10.1161/hypertensionaha.123.20282
• 发表时间: 2023
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Dines,VirginiaA;Kattah,AndreaG;Weaver,AmyL;Vaughan,LisaE;Chamberlain,AlannaM;Bielinski,SuzetteJ;Mielke,MichelleM;Garovic,VesnaD
• 通讯作者: Garovic,VesnaD

Buffy Coat DNA Methylation Profile Is Representative of Methylation Patterns in White Blood Cell Types in Normal Pregnancy.

• DOI: 10.3389/fbioe.2021.782843
• 发表时间: 2021
• 期刊: Frontiers in bioengineering and biotechnology
• 影响因子: 5.7
• 作者: Ghamrawi R;Velickovic I;Milicevic O;White WM;Thistlethwaite LR;Cunningham JM;Milosavljevic A;Milic NM;Garovic VD
• 通讯作者: Garovic VD

Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia.

严重表型先兆子痫的补体替代途径的定量改变和相关遗传分析。

• DOI: 10.34067/kid.0000992021
• 发表时间: 2021
• 期刊: Kidney360
• 作者: Alrahmani,Layan;GonzalezSuarez,MariaL;Cousin,MargotA;Moyer,AnnM;Willrich,MariaAliceV;White,WendyM;Wick,MyraJ;Tostrud,LindaJ;Narang,Kavita;Garovic,VesnaD
• 通讯作者: Garovic,VesnaD