Implementation of ring strategy for community-engaged control of neurocysticercosis
社区参与控制神经囊尾蚴病环策略的实施
基本信息
- 批准号:10674839
- 负责人:
- 金额:$ 49.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-12-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAdoptionAfricaAntigensAreaAsiaAwardBiological AssayBiomedical ResearchBrainBrain DiseasesClinical ResearchCluster randomized trialCollaborationsCommunitiesCommunity TrialConsolidated Framework for Implementation ResearchCost AnalysisCountryCysticercosisDetectionDiseaseDoseEconomicsEffectivenessEffectiveness of InterventionsEpilepsyEvaluationEvidence based interventionFamily suidaeGoalsGovernmentGrowthHeadHealthHomeHumanInfectionInstitutionInterventionLatin AmericaLiteratureMaintenanceMeasurementMeatModelingNeurocysticercosisOutcomeParasitesPeruPeruvianPharmaceutical PreparationsPilot ProjectsPopulationPositioning AttributeProcessProductivityProtocols documentationPublic HealthRandomizedReportingResearchResearch MethodologyResource-limited settingRiskRunningSeriesStructureSurveillance MethodsTaenia soliumTeniasisTestingTimeTongueTrainingTraining and InfrastructureTranslational ResearchUnited States National Institutes of HealthUniversitiesUrineWashingtonWorld Health OrganizationZoonosescontrol trialcostdiagnostic tooldisability-adjusted life yearsenteric infectionepidemiology studyfoodborneformative assessmentglobal healthhigh riskimplementation evaluationimplementation researchimplementation sciencenervous system disordernovel diagnosticspreventpreventable epilepsyprogramsscale upscreeningsoundtraining opportunitytransmission processtreatment responseworking group
项目摘要
PROJECT SUMMARY
Neurocysticercosis (NCC) is a common neurologic disease and a leading cause of preventable epilepsy in
Asia, Africa, and Latin America. It is caused by central nervous infection with Taenia solium (the pork
tapeworm). While there has been considerable recent progress in developing interventions to control
transmission, programmatic adoption of these strategies has lagged far behind. There is an urgent need for
sound implementation research to ensure that the most effective and practical strategies can be adopted. Over
the past 7 years we developed, optimized, and tested a targeted approach known as ring treatment that takes
advantage of the strong spatial clustering between human and pig hosts of this zoonotic disease. Surveillance
and detection of pig infection (cysticercosis), which is visible in meat at time of slaughter and in the tongues of
live pigs, leads to treatment for taeniasis (human intestinal infection) in nearby homes. This strategy provides a
simple and practical method for surveillance leading to efficient treatment of those humans at highest risk of
being infected with taeniasis. In a head-to-head cluster randomized trial over 2 years, ring treatment achieved
the same robust level of reduced parasite transmission as mass treatment (69.3% vs. 64.7% reduction,
respectively) but did so using only a small fraction of the drug (1791 vs. 11,186 doses). However, a number of
barriers exist that must still be solved for ring treatment to adopted a control program.
In this 5-year project, we use the Consolidated Framework for Implementation Research (CFIR) to develop an
adoptable approach for ring treatment as a control program for T. solium. We first use formative evaluation with
stakeholders to develop intervention protocols, then refine these protocols through a pilot study with iterative
evaluation. We then evaluate ring treatment implementation as a government run and community-engaged
program in a 3 year trial, following the cRE-AIM framework (cost, reach, adoption, implementation, and
maintenance). We also evaluate the utility and effectiveness of integrating a new urine screening assay for
cysticercosis in ring treatment intervention. Finally, we provide a series of didactic and applied implementation
research training opportunities for trainees to advance capacity for implementation research in Peru.
项目摘要
脑囊虫病(NCC)是一种常见的神经系统疾病,也是可预防癫痫的主要原因,
亚洲、非洲和拉丁美洲。它是由中枢神经感染猪带绦虫(猪肉
绦虫)。虽然最近在制定干预措施以控制
然而,在传播方面,这些战略的方案采用远远落后。迫切需要
进行健全的执行研究,以确保采取最有效和最实际的战略。超过
在过去的7年里,我们开发,优化和测试了一种称为环治疗的有针对性的方法,
这种人畜共患疾病的人和猪宿主之间的强空间聚集性的优势。监控
以及检测猪感染(囊虫病),这是可见的肉在屠宰时,并在舌头的
生猪,导致治疗绦虫病(人类肠道感染)在附近的家庭。该战略提供了一个
一种简单实用的监测方法,可有效治疗最高风险的人,
感染了绦虫病在一项为期2年的头对头群集随机试验中,
与大量处理相同的降低寄生虫传播的稳健水平(69.3%对64.7%降低,
但只使用了一小部分药物(1791对11,186剂量)。但若干
对于采用控制程序的环处理来说,仍然存在必须解决的障碍。
在这个为期5年的项目中,我们使用实施研究的综合框架(CFIR)来开发一个
可采用的环处理方法作为T.索利亚我们首先使用形成性评价,
利益相关者制定干预协议,然后通过迭代的试点研究完善这些协议,
评价然后,我们评估政府运营和社区参与的环治疗实施情况
在一个为期3年的试验计划,遵循cRE-AIM框架(成本,覆盖范围,采用,实施,
维护)。我们还评估了整合一种新的尿液筛查检测方法的实用性和有效性,
囊虫病的干预治疗。最后,给出了一系列教学和应用的实现
为受训人员提供研究培训机会,以提高秘鲁的执行研究能力。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Geographically Targeted Interventions versus Mass Drug Administration to Control Taenia solium Cysticercosis, Peru.
- DOI:10.3201/eid2709.203349
- 发表时间:2021-09
- 期刊:
- 影响因子:11.8
- 作者:O'Neal SE;Pray IW;Vilchez P;Gamboa R;Muro C;Moyano LM;Ayvar V;Gavidia CM;Gilman RH;Gonzalez AE;Garcia HH;Cysticercosis Working Group in Peru
- 通讯作者:Cysticercosis Working Group in Peru
Evaluating Urban Taeniasis as a Threat to Cysticercosis Elimination in Northern Peru.
评估城市绦虫病对秘鲁北部消除囊尾蚴病的威胁。
- DOI:10.4269/ajtmh.18-0767
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Fernandez,Lauralee;Gamboa,Ricardo;Vilchez,Percy;Pray,Ian;Beam,Michelle;Garvey,Brian;Spencer,Angela;Atto,Ruth;Muro,Claudio;Moyano,LuzMaria;Garcia,HectorH;O'Neal,SethE;ForTheCysticercosisWorkingGroupInPeru
- 通讯作者:ForTheCysticercosisWorkingGroupInPeru
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{{ truncateString('Javier A Bustos', 18)}}的其他基金
Combined Albendazole and Praziquantel in Subarachnoid NCC, CCC, Lead application
联合阿苯达唑和吡喹酮治疗蛛网膜下腔 NCC、CCC、铅应用
- 批准号:
9751405 - 财政年份:2015
- 资助金额:
$ 49.45万 - 项目类别:
Use of bisphosphonates to reduce the calcification process in animal models of cysticercosis
使用双膦酸盐减少囊尾蚴病动物模型的钙化过程
- 批准号:
9024412 - 财政年份:2015
- 资助金额:
$ 49.45万 - 项目类别:
Use of bisphosphonates to reduce the calcification process in animal models of cysticercosis
使用双膦酸盐减少囊尾蚴病动物模型的钙化过程
- 批准号:
9207421 - 财政年份:2015
- 资助金额:
$ 49.45万 - 项目类别:
Interdisciplinary Cerebrovascular Diseases Training Program in South America
南美跨学科脑血管病培训项目
- 批准号:
10183363 - 财政年份:2014
- 资助金额:
$ 49.45万 - 项目类别:
Implementation of ring strategy for community-engaged control of neurocysticercosis
社区参与控制神经囊尾蚴病环策略的实施
- 批准号:
10229455 - 财政年份:2013
- 资助金额:
$ 49.45万 - 项目类别:
Implementation of ring strategy for community-engaged control of neurocysticercosis
社区参与控制神经囊尾蚴病环策略的实施
- 批准号:
10461003 - 财政年份:2013
- 资助金额:
$ 49.45万 - 项目类别:
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