Geographically Targeted Interventions versus Mass Drug Administration to Control Taenia solium Cysticercosis, Peru.
Geographically Targeted Interventions versus Mass Drug Administration to Control Taenia solium Cysticercosis, Peru.
复制标题
秘鲁控制猪带绦虫囊虫病的地理针对性干预与大规模药物管理。
DOI：
10.3201/eid2709.203349
复制
发表时间：
2021-09
影响因子：
11.8
通讯作者：
Cysticercosis Working Group in Peru
中科院分区：
文献类型：
--
作者：
O'Neal SE;Pray IW;Vilchez P;Gamboa R;Muro C;Moyano LM;Ayvar V;Gavidia CM;Gilman RH;Gonzalez AE;Garcia HH;Cysticercosis Working Group in Peru
猪带绦虫病和囊虫病的最佳控制策略尚未确定。我们在秘鲁进行了一项为期2年的随机分组试验，将23个村庄分配到3种地理目标干预方法中的1种。对于环形筛查（RS），对居住在猪囊虫病附近的参与者进行了带绦虫病筛查;确定的病例用氯硝柳胺治疗。在环形治疗（RT）中，居住在猪囊虫病附近的参与者接受了氯硝柳胺的假定治疗。在大规模治疗（MT）中，参与者每6个月接受一次氯硝柳胺治疗，无论地点如何。在每种方法中，一半的那些村庄接受了针对猪的奥芬达唑或大规模奥芬达唑（共6个研究组）。我们注意到所有方法中猪的血清发病率显著降低（RS降低67.1%，RT降低69.3%，MT降低64.7%; p<0.001），尽管靶向方法治疗的群体比例较小（RS 1.4%，RT 19.3%，MT 88.5%）。我们的研究结果表明，多种方法可以实现快速控制T。氦气传输
Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention approaches. For ring screening (RS), participants living near pigs with cysticercosis were screened for taeniasis; identified cases were treated with niclosamide. In ring treatment (RT), participants living near pigs with cysticercosis received presumptive treatment with niclosamide. In mass treatment (MT), participants received niclosamide treatment every 6 months regardless of location. In each approach, half the villages received targeted or mass oxfendazole for pigs (6 total study arms). We noted significant reductions in seroincidence among pigs in all approaches (67.1% decrease in RS, 69.3% in RT, 64.7% in MT; p<0.001), despite a smaller proportion of population treated by targeted approaches (RS 1.4%, RT 19.3%, MT 88.5%). Our findings suggest multiple approaches can achieve rapid control of T. solium transmission.
登录
查看更多内容
DOI：
10.4269/ajtmh.2009.81.433
发表时间：
2009-09-01
影响因子：
3.3
作者：
Guezala, Maria-Claudia;Rodriguez, Silvia;Craig, Philip S.
通讯作者：
Craig, Philip S.
影响因子：
3.3
作者：
Muro, Claudio;Gomez-Puerta, Luis A.;O'Neal, Seth E.
通讯作者：
O'Neal, Seth E.
DOI：
10.4269/ajtmh.1996.54.391
发表时间：
1996-04-01
影响因子：
3.3
作者：
Gonzales, AE;Garcia, HH;LopezUrbina, MT
通讯作者：
LopezUrbina, MT
影响因子：
4
作者：
Assana E;Kyngdon CT;Gauci CG;Geerts S;Dorny P;De Deken R;Anderson GA;Zoli AP;Lightowlers MW
通讯作者：
Lightowlers MW
影响因子：
11.8
作者：
O'Neal SE;Flecker RH
通讯作者：
Flecker RH