Cancer Epidemiology and Prevention Program

摘要：癌症流行病学和预防（CEP） 癌症流行病学和预防（CEP）计划的首要目标是减少癌症负担 和死亡率在我们的集水区和超越通过三个互动主题的连续性， 癌症的预防和早期发现。主题1：风险和因果关系的发现 癌症发展和进展的因素，具体目的是发现和表征新的 可改变和不可改变的风险和癌症发展的因果因素。主题二：癌症预防 其具体目的是发现和评价新的抗癌天然化合物和疫苗， 癌症发病率主题3是癌症筛查和早期检测，具体目标是发展和 验证用于癌症早期诊断的新型生物标志物和现代成像技术， 癌症的结果和减少癌症死亡。这些主题反映了主要的工作组和倡议 联合项目成员与其他癌症中心的研究人员， 合作，以实现这些具体目标。 在James赫尔曼（MD）（共同负责人）和袁建民（MD，PhD）（共同负责人）的领导下，CEP 有26名成员，代表匹兹堡大学2个学院的11个系。这些程序 成员已获得540万美元（每年直接总额）的研究补助金，其中360万美元来自 NCI和其他来源的180万美元。所有CEP成员都从事癌症相关研究，重点是 发现癌症发展的新风险/致病因素，原发性癌症的疗效 预防策略和癌症筛查及早期检测方法的有效性。CEP成员 与BCC计划合作并对其工作进行补充，该计划的重点是风险的实施 行为改变计划，如戒烟和体重控制和减少。2015年至 2019年8月，CEP成员发表了639篇癌症相关论文，这些论文来自10%的项目内研究， 27%是计划间合作，81%是机构间合作， Science，Nature，JAMA，Lancet，JNCI和JCO。该计划的成员带来了他们的科学活力， UPMC希尔曼癌症中心（HCC）提供基于人群的研究专业知识，并提供独特的教育 和培训经验的下一代科学家进行尖端的转化研究， 癌症病因学和预防。在HCC的出色支持下，这一高效的CEP已 成功地在计划成员与HCC其他计划成员之间建立了协同作用， 其他癌症中心，这导致了许多团队科学项目，推动了该计划的研究 施政纲要的演讲在HCC战略计划的指导下，CEP成员将制定和建立大型倡议， 实施对HCC集水区癌症负担有重大影响的研究项目。

Abstract: Cancer Epidemiology and Prevention (CEP) The overarching goal of the Cancer Epidemiology and Prevention (CEP) Program is to reduce cancer burden and mortality in our catchment area and beyond through three interactive themes on the continuum from cancer initiations to cancer prevention and early detection. Theme 1 is Discovery of Risk and Causative Factors for Cancer Development and Progression with a specific aim to discover and characterize novel modifiable and unmodifiable risk and causal factors for cancer development. Theme 2 is Cancer Prevention with a specific aim to discover and evaluate novel anti-cancer natural compounds and vaccines for reduction of cancer incidence. Theme 3 is Cancer Screening and Early Detection with a specific aim to develop and validate novel biomarkers and modern imaging technologies for early diagnosis of cancer, for improvement of cancer outcomes and reduction of cancer death. These themes reflect major working groups and initiatives that coalesce program members with other cancer center investigators, through inter-programmatic collaborations to achieve these specific aims. Under the leadership of James Herman, MD (co-leader) and Jian-Min Yuan, MD, PhD (co-leader), the CEP has 26 members representing 11 departments in 2 schools of the University of Pittsburgh. These Program members have been awarded $5.4M (annual total direct) research grant funding, of which $3.6M is from the NCI and $1.8M from other sources. All CEP members are engaged in cancer-relevant research focusing on the discovery of novel risk/causative factors for the development of cancer, the efficacy of primary cancer prevention strategies and effectiveness of cancer screening and early detection methods. CEP members collaborate with and compliment the efforts of the BCC program, which focuses on implementation of risk behavioral change programs such as smoking cessation and weight control and reduction. Between 2015 and August 2019, CEP members published 639 cancer-relevant papers that resulted from 10% intra-programmatic, 27% inter-programmatic, and 81% inter-institutional collaborations and included high-impact publications in Science, Nature, JAMA, Lancet, JNCI, and JCO. The program members bring their scientific vigor and population-based research expertise to UPMC Hillman Cancer Center (HCC) and provide unique education and training experience to the next generation of scientists to conduct cutting-edge translational research on cancer etiology and prevention. With the outstanding support of HCC, this highly effective CEP has successfully created synergy among the Program members with members of HCC other programs as well as other cancer centers, which have resulted in many team science projects that advance the program’s research agenda. Guided by the HCC strategic plan, the CEP members will develop and build large initiatives and implement research projects that have significant impact on cancer burden in the HCC catchment area.