Core - Biomarker Reference Laboratory (BRL)
核心 - 生物标志物参考实验室 (BRL)
基本信息
- 批准号:10705806
- 负责人:
- 金额:$ 19.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-16 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressBaltimoreBenignBiological AssayBiological MarkersBiopsyBlindedBody FluidsCLIA certifiedCancer EtiologyCategoriesCellsCessation of lifeCharacteristicsClinicalCollaborationsDNA MethylationDetectionDevelopmentDiagnostic ProcedureDiameterDiseaseEarly Detection Research NetworkEarly DiagnosisEnsureEvaluationExhibitsFundingHealthcareImageKnowledgeLaboratoriesLesionLongterm Follow-upLungMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of lungMarylandMethodologyMethodsMethylationMorbidity - disease rateNoduleOperative Surgical ProceduresParticipantPatientsPerformancePlasmaPopulationPredictive ValueProceduresQuality ControlReagentReproducibilityResearch PersonnelSamplingScreening ResultSpecificityStandardizationTechnologyTestingTimeUniversitiesValidationarmassay developmentbiomarker developmentbiomarker validationcandidate markerexperienceflexibilitylaboratory developmentliquid biopsylung cancer screeningmethylation biomarkermortalitymultidisciplinaryprospectivesample collectionscreeningwasting
项目摘要
The Biomarker Reference Laboratory (BRL) will be led by Dr. Sanford Stass and as a
component of the BCC will develop, refine, and standardize the biomarkers assays developed
by the Biomarker Development Laboratory. This BRL is a continuation of the University of
Maryland Baltimore Biomarker Reference Laboratory. UMB-BRL has for the past 15 years
provided active support of the EDRN, including testing of candidate biomarkers, development of
assays and technologies, and standardization of assay methods in collaboration with multiple
investigators in the EDRN. The proposed BRL includes a multi-disciplinary team of directors/co-
investigators and staff with broad knowledge, experience and expertise in application of
technology for biomarkers including reagent and assay development and implementation,
validation of laboratory methodology and assays, quality control for reagents and technologies,
evaluation of accuracy, precision, reproducibility and characteristics of performance including
sensitivity, specificity, and positive and negative predictive values. The BRL will bring DNA
methylation biomarkers from the BDL into a CLIA compliant laboratory using developed
standard operating procedures (SOPs), and extensive experience in collaborative studies in
biomarker validation.
生物标志物参考实验室(BRL)将由Sanford Stass博士领导,并作为生物标志物参考实验室主任
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES G. HERMAN其他文献
JAMES G. HERMAN的其他文献
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{{ truncateString('JAMES G. HERMAN', 18)}}的其他基金
Optimizing Ultrasensitive DNA methylation detection for lung cancer and other malignancies
优化肺癌和其他恶性肿瘤的超灵敏 DNA 甲基化检测
- 批准号:
10705752 - 财政年份:2022
- 资助金额:
$ 19.77万 - 项目类别:
Core - Biomarker Development Laboratory (BDL)
核心 - 生物标志物开发实验室 (BDL)
- 批准号:
10705802 - 财政年份:2022
- 资助金额:
$ 19.77万 - 项目类别:
Ultrasensitive Detection of Tumor Specific DNA Methylation Changes for the Early Detection of Lung Cancer
超灵敏检测肿瘤特异性 DNA 甲基化变化以早期发现肺癌
- 批准号:
9277030 - 财政年份:2016
- 资助金额:
$ 19.77万 - 项目类别:
Ultrasensitive Detection of Tumor Specific DNA Methylation Changes for the Early Detection of Lung Cancer
超灵敏检测肿瘤特异性 DNA 甲基化变化以早期发现肺癌
- 批准号:
10463037 - 财政年份:2016
- 资助金额:
$ 19.77万 - 项目类别:
Ultrasensitive Detection of Tumor Specific DNA Methylation Changes for the Early Detection of Lung Cancer
超灵敏检测肿瘤特异性 DNA 甲基化变化以早期发现肺癌
- 批准号:
9353351 - 财政年份:2016
- 资助金额:
$ 19.77万 - 项目类别:
CHFR Methylation for Predicting Taxane Sensitivity in Lung and Esophageal Cancer
CHFR 甲基化用于预测肺癌和食道癌紫杉烷敏感性
- 批准号:
7667386 - 财政年份:2008
- 资助金额:
$ 19.77万 - 项目类别:
P1: Epigenetic Staging and Therapy for Lung Cancers
P1:肺癌的表观遗传分期和治疗
- 批准号:
7567913 - 财政年份:2008
- 资助金额:
$ 19.77万 - 项目类别:
CHFR Methylation for Predicting Taxane Sensitivity in Lung and Esophageal Cancer
CHFR 甲基化用于预测肺癌和食道癌紫杉烷敏感性
- 批准号:
7892354 - 财政年份:2008
- 资助金额:
$ 19.77万 - 项目类别:
CHFR Methylation for Predicting Taxane Sensitivity in Lung and Esophageal Cancer
CHFR 甲基化用于预测肺癌和食道癌紫杉烷敏感性
- 批准号:
8116517 - 财政年份:2008
- 资助金额:
$ 19.77万 - 项目类别:
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