Administrative Core

行政核心

• 批准号: 10705801
• 负责人: JAMES G. HERMAN
• 金额: $ 29.96万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705801
• 关键词: Biological Markers; Blood; Budgets; Clinical; Communication; Complex; Comprehensive Cancer Center; DNA Methylation; Detection; Development; Early Detection Research Network; Funding; Goals; Individual; Institution; Laboratories; Malignant Neoplasms; Malignant neoplasm of lung; Maryland; Pennsylvania; Preparation; Progress Reports; Research Personnel; Resources; Sampling; Schedule; Screening for cancer; Site; Site Visit; Testing; Travel; Universities; Validation; biomarker development; biomarker validation; innovative technologies; laboratory development; material transfer agreement; meetings; methylation biomarker; multidisciplinary; programs; research clinical testing

The development and validation of biomarkers for the early detection of cancer requires a team of investigators and resources to move from discovery through stages of validation to the ultimate goal of a clinically approved and useful test. This Biomarker Characterization Center proposes to develop and validate blood-based cancer specific DNA methylation biomarkers by bringing together investigative teams from three NCI designated Comprehensive Cancer Centers (The UMPC Hillman Comprehensive Cancer Center at the University of Pittsburgh, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, and The University of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center) to accomplish this complex task. To coordinate and support these efforts, an administrative core will integrate activities of EDRN BCC investigators. The administrative core of this Biomarker Characterization Center oversees, coordinates and supports the activities of this multidisciplinary program. Through overseeing and supporting these activities, the individual components of the Biomarker Development Laboratory and the Biomarker Reference Laboratory are able to effectively accomplish their objectives and integrate their activities with other components of the BCC (BDL and BRL), with other NCI programs and with other EDRN centers (BCCs, CVCs and the DMCC).

开发和验证用于癌症早期检测的生物标志物需要一个团队