Surgical Oncology Research Training Grant

肿瘤外科研究培训补助金

• 批准号: 10674795
• 负责人: Babak J Mehrara
• 金额: $ 50.93万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674795
• 关键词: Grant; Research Training; Surgical Oncology

PROJECT SUMMARY/ABSTRACT We propose to continue our program to provide research training in oncology to young surgeons interested in a career in academic surgical oncology. Trainees will be surgical residents with at least 2 years of postgraduate clinical experience. Our T32 Surgical Oncology Research Training Program has supported the research careers of 85 young trainee surgeons over the past 30 years. We are now applying for funding for years 31 to 35. The goals of the 2-year training program are to provide individuals with an intensive research experience in (1) hypothesis formulation, (2) experimental design, (3) data analysis, (4) laboratory/project management, (5) oral and written presentation, and (6) grant writing skills. The ultimate objective of the program is to teach the scientific method and research techniques so that the trainees can perform high-quality independent research on topics ranging the full spectrum of oncology upon completion of their surgical training. This research experience will enable trainees to apply for positions as junior faculty members in academic institutions and become independent clinical and translational researchers. The mentored research will be tailored to the interest and career goals of the trainees and their mentors. Past trainees have worked in a wide variety of disciplines, including tumor immunology, cancer biology, molecular genetics, molecular pathology, and targeted therapeutics. For the proposed cycle, we have added Program Faculty with research programs in cancer outcomes, survivorship, and disparities. The program curriculum is now designed to provide exposure to basic, translational, and population health sciences, as well as clinical surgical oncology, medical oncology, and radiation oncology. Close contact between the trainees, mentors, and program director has been achieved. Trainees are required to attend weekly conferences and didactic lectures at Memorial Sloan Kettering Cancer Center (MSK) that include the fundamentals of research, research presentations, as well as topics in clinical oncology. The scientific quality of research performed by the trainees has been outstanding and most of the fellows have remained in academia. The program continues to be a major commitment of the Department of Surgery at MSK and has benefited from the recent increase in research faculty and research facilities at our institution.

项目概要/摘要 我们建议继续我们的计划，为对肿瘤学感兴趣的年轻外科医生提供肿瘤学研究培训 学术外科肿瘤学的职业生涯。学员将是具有至少 2 年研究生学历的外科住院医师 临床经验。我们的 T32 肿瘤外科研究培训计划支持了这项研究 过去 30 年来 85 名年轻见习外科医生的职业生涯。我们现在正在申请 31 年至 35. 为期 2 年的培训计划的目标是为个人提供以下方面的深入研究经验： (1) 假设提出，(2) 实验设计，(3) 数据分析，(4) 实验室/项目管理，(5) 口头和书面陈述，以及 (6) 授予写作技能。该计划的最终目标是教授 科学方法和研究技术，使学员能够进行高质量的独立研究 完成外科培训后，他们将学习各种肿瘤学主题。这项研究 经验将使学员能够申请学术机构的初级教员职位， 成为独立的临床和转化研究人员。指导性研究将根据 学员及其导师的兴趣和职业目标。过去的学员曾从事过各种各样的工作 学科，包括肿瘤免疫学、癌症生物学、分子遗传学、分子病理学等 靶向治疗。在拟议的周期中，我们增加了具有研究项目的项目教师 癌症结果、生存率和差异。该项目课程现在旨在提供接触机会 基础科学、转化科学和人口健康科学，以及临床外科肿瘤学、肿瘤内科、 和放射肿瘤学。学员、导师和项目总监之间的密切联系 实现了。学员必须参加纪念斯隆管理学院每周举行的会议和教学讲座 凯特林癌症中心 (MSK)，包括研究基础知识、研究演示以及 临床肿瘤学主题。学员所进行的研究的科学质量非常出色 大多数研究员仍然留在学术界。该计划仍然是一个主要承诺 MSK 斯隆外科部受益于最近研究人员和研究的增加 我们机构的设施。

项目成果

Genetically engineered oncolytic Newcastle disease virus effectively induces sustained remission of malignant pleural mesothelioma.

• DOI: 10.1158/1535-7163.mct-10-0090
• 发表时间: 2010-10
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: Silberhumer GR;Brader P;Wong J;Serganova IS;Gönen M;Gonzalez SJ;Blasberg R;Zamarin D;Fong Y
• 通讯作者: Fong Y

Lauren Histologic Type Is the Most Important Factor Associated With Pattern of Recurrence Following Resection of Gastric Adenocarcinoma.

• DOI: 10.1097/sla.0000000000002040
• 发表时间: 2018-01
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Lee JH;Chang KK;Yoon C;Tang LH;Strong VE;Yoon SS
• 通讯作者: Yoon SS

Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury.

• DOI: 10.1152/ajpcell.00284.2011
• 发表时间: 2012-02
• 期刊: American journal of physiology. Cell physiology
• 作者: Jamie C. Zampell;Sonia Elhadad;Tomer Avraham;E. Weitman;Seth Z. Aschen;Alan Yan;B. Mehrara

Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.

• DOI: 10.1245/s10434-021-10877-3
• 发表时间: 2022-03
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Kim JK;Thompson H;Jimenez-Rodriguez RM;Wu F;Sanchez-Vega F;Nash GM;Guillem JG;Paty PB;Wei IH;Pappou EP;Widmar M;Weiser MR;Smith JJ;Garcia-Aguilar J
• 通讯作者: Garcia-Aguilar J

Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.

• DOI: 10.1158/1078-0432.ccr-10-0253
• 发表时间: 2011-01-01
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Bachleitner-Hofmann T;Sun MY;Chen CT;Liska D;Zeng Z;Viale A;Olshen AB;Mittlboeck M;Christensen JG;Rosen N;Solit DB;Weiser MR
• 通讯作者: Weiser MR