Surgical Oncology Research Training Grant

肿瘤外科研究培训补助金

• 批准号: 10674795
• 负责人: Babak J Mehrara
• 金额: $ 50.93万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674795
• 关键词: Grant; Research Training; Surgical Oncology

PROJECT SUMMARY/ABSTRACT We propose to continue our program to provide research training in oncology to young surgeons interested in a career in academic surgical oncology. Trainees will be surgical residents with at least 2 years of postgraduate clinical experience. Our T32 Surgical Oncology Research Training Program has supported the research careers of 85 young trainee surgeons over the past 30 years. We are now applying for funding for years 31 to 35. The goals of the 2-year training program are to provide individuals with an intensive research experience in (1) hypothesis formulation, (2) experimental design, (3) data analysis, (4) laboratory/project management, (5) oral and written presentation, and (6) grant writing skills. The ultimate objective of the program is to teach the scientific method and research techniques so that the trainees can perform high-quality independent research on topics ranging the full spectrum of oncology upon completion of their surgical training. This research experience will enable trainees to apply for positions as junior faculty members in academic institutions and become independent clinical and translational researchers. The mentored research will be tailored to the interest and career goals of the trainees and their mentors. Past trainees have worked in a wide variety of disciplines, including tumor immunology, cancer biology, molecular genetics, molecular pathology, and targeted therapeutics. For the proposed cycle, we have added Program Faculty with research programs in cancer outcomes, survivorship, and disparities. The program curriculum is now designed to provide exposure to basic, translational, and population health sciences, as well as clinical surgical oncology, medical oncology, and radiation oncology. Close contact between the trainees, mentors, and program director has been achieved. Trainees are required to attend weekly conferences and didactic lectures at Memorial Sloan Kettering Cancer Center (MSK) that include the fundamentals of research, research presentations, as well as topics in clinical oncology. The scientific quality of research performed by the trainees has been outstanding and most of the fellows have remained in academia. The program continues to be a major commitment of the Department of Surgery at MSK and has benefited from the recent increase in research faculty and research facilities at our institution.

项目总结/文摘

项目成果

Genetically engineered oncolytic Newcastle disease virus effectively induces sustained remission of malignant pleural mesothelioma.

• DOI: 10.1158/1535-7163.mct-10-0090
• 发表时间: 2010-10
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: Silberhumer GR;Brader P;Wong J;Serganova IS;Gönen M;Gonzalez SJ;Blasberg R;Zamarin D;Fong Y
• 通讯作者: Fong Y

Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury.

• DOI: 10.1152/ajpcell.00284.2011
• 发表时间: 2012-02
• 期刊: American journal of physiology. Cell physiology
• 作者: Jamie C. Zampell;Sonia Elhadad;Tomer Avraham;E. Weitman;Seth Z. Aschen;Alan Yan;B. Mehrara

Lauren Histologic Type Is the Most Important Factor Associated With Pattern of Recurrence Following Resection of Gastric Adenocarcinoma.

• DOI: 10.1097/sla.0000000000002040
• 发表时间: 2018-01
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Lee JH;Chang KK;Yoon C;Tang LH;Strong VE;Yoon SS
• 通讯作者: Yoon SS

Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.

• DOI: 10.1245/s10434-021-10877-3
• 发表时间: 2022-03
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Kim JK;Thompson H;Jimenez-Rodriguez RM;Wu F;Sanchez-Vega F;Nash GM;Guillem JG;Paty PB;Wei IH;Pappou EP;Widmar M;Weiser MR;Smith JJ;Garcia-Aguilar J
• 通讯作者: Garcia-Aguilar J

Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.

• DOI: 10.1158/1078-0432.ccr-10-0253
• 发表时间: 2011-01-01
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Bachleitner-Hofmann T;Sun MY;Chen CT;Liska D;Zeng Z;Viale A;Olshen AB;Mittlboeck M;Christensen JG;Rosen N;Solit DB;Weiser MR
• 通讯作者: Weiser MR