Decoding tobacco-related oral cancer ecosystem by integrative approach
Decoding tobacco-related oral cancer ecosystem by integrative approach
批准号:
10677015
负责人:
CHRISTINE H CHUNG
金额:
$45.71万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-01 至 2024-08-31
关键词:
AffectAlcohol consumptionBindingBiologicalCancer PatientCell LineCell physiologyCellsCetuximabChronicClinicalClinical DataDataData SourcesEcosystemEvaluationFDA approvedGene ExpressionGenomic DNAGenomicsHistologyHuman Papilloma Virus-Related Malignant NeoplasmHuman papilloma virus infectionImmuneImmune systemImmunotherapeutic agentImmunotherapyInflammatoryLigandsMachine LearningMapsModelingMolecularMultiomic DataNivolumabOral CharactersOral cavityOropharyngealOutcomePatientsPharmaceutical PreparationsPhenotypePrognosisPublishingResearchResearch PersonnelRisk FactorsSafetySmokerSquamous cell carcinomaT-LymphocyteTestingThe Cancer Genome AtlasTherapeuticTherapeutic AgentsTobaccoTobacco useTobacco-Related CarcinomaValidationanti-PD-1anticancer researchbak proteincandidate validationcell typeclinical phenotypeclinically significantcohortexposure to cigarette smokeimmunogenic cell deathimprovedin vivomalignant mouth neoplasmmouse modelmultiple omicsnovelnovel therapeuticsoral HPV infectionpembrolizumabprognosticprogrammed cell death ligand 1programmed cell death protein 1responsetargeted agenttobacco exposuretumortumor-immune system interactionsuser-friendlyweb portal
中文摘要
项目总结
口腔癌的已知危险因素是吸烟和饮酒以及人类乳头瘤病毒(HPV)感染。
烟草使用和HPV感染之间存在明显的相互作用。吸烟者的吸烟率要高得多
口腔HPV持续感染是发展为口腔癌的重要危险因素。患有烟草的患者-
相关的口腔癌预后较差。除了烟草对基因组DNA造成的明显损害外,
暴露在香烟烟雾中也会显著影响免疫系统。最近,免疫疗法已经成为
这是口腔癌一个很有前途的治疗选择。细胞程序性死亡-1(PD-1)是临床上常见的
重要的检查点分子,已被证明在与其配体结合时抑制T细胞的功能,
PD-L1和PD-L2。Nivolumab和pembrolizumab是两种最有效和最安全的PD-1抑制剂
口腔癌治疗中的数据。虽然持续使用烟草的有害影响一直是
多年来,烟草使用对肿瘤免疫微环境(时间)和
对口腔癌的免疫治疗效果的研究很少。在这项建议中,我们将全面
通过综合多组学方法评估烟草对口腔癌生态系统的影响,
利用口腔癌症特异性时间寻找新的治疗药物,并开发口腔癌症特异性药物
促进烟草相关癌症研究领域的门户网站。
英文摘要
PROJECT SUMMARY
Known risk factors for oral cancers are tobacco and alcohol use and human papillomavirus (HPV) infection.
There is a clear interaction between tobacco use and HPV infection. Smokers have a significantly higher rate
of persistent oral HPV infection which is a significant risk factor to develop oral cancer. Patients with tobacco-
related oral cancers have poor prognosis. Apart from the obvious damage tobacco causes to genomic DNA,
cigarette smoke exposure also significantly impacts the immune system. Recently immunotherapy has become
a promising therapeutic option in oral cancer. Programmed cell death-1 (PD-1) is one of the clinically
significant checkpoint molecules that have been shown to suppress T-cell function upon binding to its ligands,
PD-L1 and PD-L2. Nivolumab and pembrolizumab are the two PD-1 inhibitors with the most efficacy and safety
data in management of oral cancer. While the detrimental effects of continued tobacco use have been
established over the years, the effects of tobacco use in the tumor immune microenvironment (TIME) and
immunotherapy efficacy in oral cancers are poorly investigated. In this proposal, we will comprehensively
evaluate the tobacco-related effects on the oral cancer ecosystem through integrated multi-omics approaches,
identify novel therapeutic agents leveraging the oral cancer-specific TIME, and develop an oral cancer specific
web portal to advance the field in tobacco-related cancer research.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Exploring the Landscape of Immune Checkpoint Inhibitor-Induced Adverse Events Through Big Data Mining of Pan-Cancer Clinical Trials.
通过泛癌症临床试验的大数据挖掘探索免疫检查点抑制剂引起的不良事件的情况。
DOI:
10.1093/oncolo/oyae012
发表时间:
2024
期刊:
The oncologist
影响因子:
--
作者:
[Fadlullah,MuhammadZakiHidayatullah, Lin,Ching-Nung, Coleman,Samuel, Young,Arabella, Naqash,AbdulRafeh, Hu-Lieskovan,Siwen, Tan,AikChoon]
通讯作者:
Tan,AikChoon
DOI:
10.1142/s0219720023500026
发表时间:
2023-02
期刊:
Journal of bioinformatics and computational biology
影响因子:
1
作者:
[]
通讯作者:
DOI:
10.3390/genes14081599
发表时间:
2023-08-08
期刊:
GENES
影响因子:
3.5
作者:
[Hu, Min, Coleman, Samuel, Fadlullah, Muhammad Zaki Hidayatullah, Spakowicz, Daniel, Chung, Christine H., Tan, Aik Choon]
通讯作者:
Tan, Aik Choon
Decoding tobacco-related oral cancer ecosystem by integrative approach
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批准号:10733337
-
项目类别:
-
资助金额:$46.28万
-
财政年份:2022
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Decoding tobacco-related oral cancer ecosystem by integrative approach
-
批准号:10478213
-
项目类别:
-
资助金额:$4.73万
-
财政年份:2021
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Decoding tobacco-related oral cancer ecosystem by integrative approach
-
批准号:10367057
-
项目类别:
-
资助金额:$62.57万
-
财政年份:2021
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Smad4-independent TGF-b signaling in p16-negative HNSCC
-
批准号:8700647
-
项目类别:
-
资助金额:$24.3万
-
财政年份:2014
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Integrated Translational Genoproteomics Center at Washington University
-
批准号:8845178
-
项目类别:
-
资助金额:$57.08万
-
财政年份:2014
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Smad4-independent TGF-b signaling in p16-negative HNSCC
-
批准号:8889662
-
项目类别:
-
资助金额:$4.1万
-
财政年份:2014
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Integrated Translational Genoproteomics Center at Washington University
-
批准号:8605709
-
项目类别:
-
资助金额:$60.0万
-
财政年份:2014
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Integrated Translational Genoproteomics Center at Washington University
-
批准号:9036857
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2014
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Molecular signatures of HNSCC in response to targeted therapies
-
批准号:8204526
-
项目类别:
-
资助金额:$38.94万
-
财政年份:2007
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Molecular signatures of HNSCC in response to targeted therapies
-
批准号:7618198
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项目类别:
-
资助金额:$37.95万
-
财政年份:2007
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Molecular signatures of HNSCC in response to targeted therapies
-
批准号:8195299
-
项目类别:
-
资助金额:$40.14万
-
财政年份:2007
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Molecular signatures of HNSCC in response to targeted therapies
-
批准号:7317063
-
项目类别:
-
资助金额:$38.38万
-
财政年份:2007
-
负责人:CHRISTINE H CHUNG
-
依托单位:
Molecular signatures of HNSCC in response to targeted therapies
-
批准号:7471496
-
项目类别:
-
资助金额:$37.95万
-
财政年份:2007
-
负责人:CHRISTINE H CHUNG
-
依托单位:
海外基金