P30 Core Grant for Vision Research

项目摘要-生物信息学和统计核心 生物信息学和统计核心的目的是提供生物信息和统计支助 用于临床、基因组和实验室研究。各种各样的研究都得到了核心的支持。这 在上一个供资期间对核心进行了修改，以包括生物信息学分析，特别是 应MEE的要求进行基因表达分析(RNAseq和微阵列)的专业知识 调查人员。核心资源面向拥有合格R01的MEE调查人员，但也 被其他调查人员使用，对于年轻的调查人员来说尤其有价值 启动新的研究项目，否则他们将无法获得这些资源。这个 生物信息学和统计核心资源和专家人员为 合作并激发新的研究想法和调查。通过帮助调查人员计划 有效调查和高效、适当地分析实验数据，生物统计 CORE提高了MEEI的视觉研究质量，并促进了 视觉科学项目。与这项P30核心拨款的其他核心类似，提供的资源 以此为核心广泛影响翻译基础科学发现，提高我们的认识 研究临床疾病的病原学特征，并开发新的治疗方法和诊断模式。 特别是，核心资源的可用性吸引了临床研究人员进入研究性研究， 从而加强研究成果的翻译。

Project summary- Bioinformatics and Statistics Core The purpose of the Bioinformatics and statistics core is to provide bioinformatic and statistical support for clinical, genomic and laboratory studies. A wide variety of studies are supported by the core. This core was modified during the previous funding period to include bioinformatic analyses, especially expertise for analysis of gene expression (RNAseq and microarrays) at the request of MEE investigators. The core resources are targeted to MEE investigators with qualifying R01s but are also used by other investigators and have been especially valuable for young investigators who are starting new research projects who would otherwise not have access to these resources. The Bioinformatics and statistics core resources and expert personnel provide opportunities for collaboration and stimulate new research ideas and investigations. By helping investigators plan effective investigations and efficiently and appropriately analyze experimental data, the biostatistics core has enhanced the quality of vision research at MEEI and has promoted increased productivity of the vision science program. Similar to the other cores for this P30 Core grant, the resources provided by this core broadly impact the translation of basic science discoveries to improve our understanding of the pathogenic features of clinical disease and to develop new therapies and diagnostic modalities. In particular, the availability of the core resources draws clinical investigators into research studies, thus enhancing the translation of research discoveries.