Program in Hematology: Molecular & Cell Biology of Blood Cells

项目总结 此重新提交申请要求继续为#年的博士后研究培训计划提供资金。 血液学成功地吸引了年轻科学家和内科科学家进入学术界 血液学和血管生物学方面的职业。该计划的主要目标是准备MD， 博士/博士和博士后研究员，从事学术科学家和内科医生的富有成效的职业- 科学家。这笔赠款支持的培训重点仍然是 血液学。我们要求每年支持四名博士后实习生(两名博士后实习生和两名博士后实习生 医学博士或医学博士实习生)，与上一批授权期保持不变。培训将会进行 在一个机构进行积极的基础、翻译和临床研究的丰富环境中 强调职业发展和协作科学。具体目标是：(1)确定 并招募不同性别、种族和文化的优秀博士后实习生，他们希望获得 全面了解有关基础研究和翻译研究的原则和技术 血液学、血细胞、血管生物学、凝血、造血和免疫生物学；(2)吸引 积极进取的科学家和内科科学家，为他们提供全面的指导 设计和实施高质量的研究项目，包括参与跨学科研究 研究团队；(3)为血液学和相关科学领域的学术生涯培训内科科学家 纪律，并为他们成功过渡到独立调查人员做好准备；以及(4)揭露 向血液学领域的有才华的博士科学家提供培训，使他们成为独立调查人员 和研究科学家。自上次更新以来，已经实施了几项新的倡议。课程设置 现在包括临床血液学的核心讲座和血液学研究方法的必要研讨会， 严谨和可重复性，并授予写作。指导委员会和个人发展计划是 所有实习生都必须参加。为内科科学家制定了一个结构化的指导计划，自 以前提交的材料。培训的基础仍然是以被指导的个人为中心 研究项目，其特点是在一个已建立的、 敬业的导师。这一培训由授课和辅导培训补充和加强 在团队科学和翻译科学方面的机会，以及接触富有成效的研究人员 从事相关领域的工作，包括在基础生物医学科学、基因组学、 计算生物学和生物信息学。多元化的师资队伍提供了丰富的培训环境， 广泛的实验室、临床和核心设施以及强有力的机构支持应确保持续 成功吸引和培养高素质的博士后实习生从事学术工作 血液学。

PROJECT SUMMARY This resubmission application requests continued funding for a postdoctoral research training program in hematology that has been successful in attracting young scientists and physician-scientists into academic careers in hematology and vascular biology. The program has as its primary objective to prepare MD, MD/PhD, and PhD postdoctoral fellows for productive careers as academic scientists and physician- scientists. The focus of training supported by this grant remains within the core scientific discipline of hematology. We are requesting support for four postdoctoral trainees per year (two PhD trainees and two MD or MD/PhD trainees), which is unchanged from the previous grant period. The training will be carried out in an enriched environment of active basic, translational and clinical investigation at an institution that emphasizes the career development and collaborative science. The specific objectives are: (1) To identify and recruit outstanding postdoctoral trainees, of diverse gender, ethnicity and culture, who wish to obtain comprehensive knowledge of the principles and techniques of basic and translational research related to hematology, blood cells, vascular biology, coagulation, hematopoiesis, and immunobiology; (2) To attract highly motivated scientists and physician-scientists and provide them with comprehensive instruction in the design and implementation of high quality research projects, including participation in cross-disciplinary research teams; (3) To train physician-scientists for academic careers in hematology and related scientific disciplines and prepare them for successful transition to independent investigators; and (4) To expose talented PhD scientists to the field of hematology and train them for careers as independent investigators and research scientists. Since the last renewal, several new initiatives have been instituted. The curriculum now includes core lectures in clinical hematology and required workshops in hematology research methods, rigor and reproducibility, and grant writing. Mentoring committees and individual development plans are required for all trainees. A structured mentoring plan for physician scientists has been developed since the previous submission. The foundation of training continues to be centered on the individual mentored research project, marked by a period of intensive, sustained research under the guidance of an established, dedicated mentor. This training is supplemented and enhanced by didactic and mentored training opportunities in team science and translational science, and by exposure to productive investigators working in related areas, including scientists with expertise in basic biomedical science, genomics, computational biology, and bioinformatics. The rich training environment provided by the diverse faculty, extensive laboratory, clinical, and core facilities, and strong institutional support should ensure continued success in attracting and preparing highly qualified postdoctoral trainees for careers in academic hematology.