Drinking Water Arsenic, Blood Pressure, and Ischemic Stroke in the REGARDS Study

REGRARDS 研究中的饮用水砷、血压和缺血性中风

• 批准号: 10681410
• 负责人: Matthew O. Gribble
• 金额: $ 11.14万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681410
• 关键词: Address; Affect; African American; Age; American Heart Association; Arsenic; Arsenicals; Biological Markers; Biology; Biometry; Blood Pressure; Cohort Analysis; Cohort Studies; Communities; Community of Practice; Country; Data; Data Analyses; Data Analytics; Data Linkages; Data Science; Data Set; Data Sources; Development; Diastolic blood pressure; Doctor of Philosophy; Documentation; Environmental Health; Epidemiology; Exposure to; Foundations; Future; Geological Survey; Goals; Guidelines; Health; Health Status; Human Biology; Hypertension; Income; Individual; Ischemic Stroke; Knowledge; Mentors; Metabolism; Methodology; Methods; Modification; National Heart, Lung, and Blood Institute; Obesity; Outcome; Outcome Study; Paper; Participant; Patient Recruitments; Persons; Population; Postdoctoral Fellow; Prevalence; Privatization; Probability; Public Health; Public Health Informatics; Race; Reasons for Geographic And Racial Differences in Stroke; Recording of previous events; Research; Resources; Risk; Risk Assessment; Risk Factors; Sample Size; Seafood; Source; Southeastern United States; Strategic vision; Stroke; System; Uncertainty; United States; United States Environmental Protection Agency; Urine; Visit; Water; Water Pollutants; Water Supply; Woman; Work; World Health Organization; analytical method; biracial; black men; burden of illness; cardiometabolism; cohort; data analysis pipeline; data integration; data streams; drinking water; epidemiology study; experience; frontier; geographic difference; ground water; hazard; informatics tool; innovation; insight; machine learning model; men; multiple data sources; novel; post stroke; predictive modeling; preventive intervention; primary outcome; response; sex; spatial epidemiology; stroke risk; tool; unpublished works; user-friendly; water quality

ABSTRACT The goal of this highly interdisciplinary project, which draws on epidemiological, hydrological, and biostatistical expertise, is to use spatial data linkage to connect drinking water arsenic data (or model predictions) to cardiometabolic health outcomes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. The REGARDS Study is a biracial (African American and white) cohort with participants recruited from across the United States, with emphasis on the Southeastern United States. The large sample size and geographic variation in this cohort make it an ideal resource for spatial drinking water arsenic epidemiology. This proposed work will support the development and refinement of a novel data analytic pipeline, which will allow integration of multiple data streams (community water system public supply water quality data, and groundwater predictions relevant for private wells) to give epidemiological inferences about drinking water arsenic and cardiometabolic health outcomes. The primary outcomes of the study are blood pressure at the REGARDS Study baseline visit, hypertension prevalence at the REGARDS Study baseline visit, and incident ischemic stroke among participants in the REGARDS Study at risk of incident ischemic stroke at baseline. The study will consider potential differences in response to arsenic according to putative effect modifiers (e.g., sex, race). Successful completion of the project aims will not only address significant knowledge gaps about drinking water arsenic’s potential salience to cardiometabolic health in the United States, but also provide a highly innovative data analysis pipeline that can be the foundation for future drinking water health research in the United States.

摘要