Drinking Water Arsenic, Blood Pressure, and Ischemic Stroke in the REGARDS Study

REGRARDS 研究中的饮用水砷、血压和缺血性中风

• 批准号: 10681410
• 负责人: Matthew O. Gribble
• 金额: $ 11.14万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681410
• 关键词: Address; Affect; African American; Age; American Heart Association; Arsenic; Arsenicals; Biological Markers; Biology; Biometry; Blood Pressure; Cohort Analysis; Cohort Studies; Communities; Community of Practice; Country; Data; Data Analyses; Data Analytics; Data Linkages; Data Science; Data Set; Data Sources; Development; Diastolic blood pressure; Doctor of Philosophy; Documentation; Environmental Health; Epidemiology; Exposure to; Foundations; Future; Geological Survey; Goals; Guidelines; Health; Health Status; Human Biology; Hypertension; Income; Individual; Ischemic Stroke; Knowledge; Mentors; Metabolism; Methodology; Methods; Modification; National Heart, Lung, and Blood Institute; Obesity; Outcome; Outcome Study; Paper; Participant; Patient Recruitments; Persons; Population; Postdoctoral Fellow; Prevalence; Privatization; Probability; Public Health; Public Health Informatics; Race; Reasons for Geographic And Racial Differences in Stroke; Recording of previous events; Research; Resources; Risk; Risk Assessment; Risk Factors; Sample Size; Seafood; Source; Southeastern United States; Strategic vision; Stroke; System; Uncertainty; United States; United States Environmental Protection Agency; Urine; Visit; Water; Water Pollutants; Water Supply; Woman; Work; World Health Organization; analytical method; biracial; black men; burden of illness; cardiometabolism; cohort; data analysis pipeline; data integration; data streams; drinking water; epidemiology study; experience; frontier; geographic difference; ground water; hazard; informatics tool; innovation; insight; machine learning model; men; multiple data sources; novel; post stroke; predictive modeling; preventive intervention; primary outcome; response; sex; spatial epidemiology; stroke risk; tool; unpublished works; user-friendly; water quality

ABSTRACT The goal of this highly interdisciplinary project, which draws on epidemiological, hydrological, and biostatistical expertise, is to use spatial data linkage to connect drinking water arsenic data (or model predictions) to cardiometabolic health outcomes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. The REGARDS Study is a biracial (African American and white) cohort with participants recruited from across the United States, with emphasis on the Southeastern United States. The large sample size and geographic variation in this cohort make it an ideal resource for spatial drinking water arsenic epidemiology. This proposed work will support the development and refinement of a novel data analytic pipeline, which will allow integration of multiple data streams (community water system public supply water quality data, and groundwater predictions relevant for private wells) to give epidemiological inferences about drinking water arsenic and cardiometabolic health outcomes. The primary outcomes of the study are blood pressure at the REGARDS Study baseline visit, hypertension prevalence at the REGARDS Study baseline visit, and incident ischemic stroke among participants in the REGARDS Study at risk of incident ischemic stroke at baseline. The study will consider potential differences in response to arsenic according to putative effect modifiers (e.g., sex, race). Successful completion of the project aims will not only address significant knowledge gaps about drinking water arsenic’s potential salience to cardiometabolic health in the United States, but also provide a highly innovative data analysis pipeline that can be the foundation for future drinking water health research in the United States.

抽象的 这个高度跨学科项目的目标是利用流行病学、水文学和生物统计学的知识 专业知识，就是利用空间数据联动，将饮用水砷数据（或模型预测）连接到 中风地理和种族差异原因中的心脏代谢健康结果 （问候）学习。 REGARDS 研究是一个混血儿（非裔美国人和白人）队列，参与者 从美国各地招募，重点是美国东南部。大样本 该群体的规模和地理差异使其成为空间饮用水砷的理想资源 流行病学。这项拟议的工作将支持新型数据分析的开发和完善 管道，这将允许集成多个数据流（社区供水系统公共供水 质量数据以及与私人水井相关的地下水预测），以提供流行病学推断 饮用水砷和心脏代谢健康结果。该研究的主要结果是血液 REGARDS 研究基线访视时的压力、REGARDS 研究基线时的高血压患病率 REGRARDS 研究中存在缺血性中风风险的参与者的就诊和缺血性中风事件 基线中风。该研究将根据假定的条件考虑对砷反应的潜在差异 效果修饰符（例如性别、种族）。项目目标的成功完成不仅将解决重大问题 关于饮用水砷对美国心脏代谢健康的潜在重要性的知识差距 州，还提供高度创新的数据分析管道，可以成为未来饮酒的基础 美国的水健康研究。