Methods to unveil sex-specific genetic architecture in trans-ancestry meta-analysis
在跨祖先荟萃分析中揭示性别特异性遗传结构的方法
基本信息
- 批准号:10681351
- 负责人:
- 金额:$ 77.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-10 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAlcohol consumptionBiologyBloodBlood PressureCause of DeathCollaborationsComplementComplexDataData AggregationData AnalysesData SetDiseaseEnvironmental ExposureEuropeanEuropean ancestryFemaleFrequenciesGeneticGenetic HeterogeneityGenetic ModelsGenetic ResearchGenetic studyHeartHeterogeneityHuman GeneticsIndividualJointsLicensingLinkage DisequilibriumLipidsLungMapsMeta-AnalysisMethodologyMethodsModelingNational Human Genome Research InstituteNon-Insulin-Dependent Diabetes MellitusObesityPatternPhenotypePopulationPopulation HeterogeneityPrevention strategyPrivacyResearchResearch PersonnelResolutionResource SharingRisk FactorsSample SizeSamplingSeriesSex RatioSoftware ToolsStrategic PlanningTobacco useTrainingUnited States National Institutes of HealthVariantaddictionancestry analysiscausal variantempowermentgenetic architecturegenetic associationgenetic variantgenome wide association studygenomic locusgenotypic seximprovedinnovationmalemethod developmentmulti-ethnicnovelnovel therapeuticspolygenic risk scorepublic health relevancerare variantrisk predictionsexstatisticstooltrait
项目摘要
ABSTRACT
Large scale genetic datasets have revolutionized human genetic research. In the past decade, genome-wide
association studies have identified numerous genetic variants associated with various complex traits. These
discoveries have informed new biology and led to novel therapeutics. Yet, most studies focused on European
samples and most of the studies were conducted by pooling both sexes together. Sex-specific genetic
architecture in diverse populations remains largely elusive. As the next step, consortia efforts have begun to
aggregate datasets from diverse non-European populations. Meta-analysis is often employed in large consortium
studies There is a compelling need to develop methods that can effectively conduct trans-ancestry meta-
analysis. To this end, we will develop a series of innovative methods to improve the power for association
mapping, the precision of fine mapping and the accuracy of polygenic predictions in trans -ancestry analysis.
Resulting methods will be applied to a series of heart, lung, and blood related traits, in collaboration with a
number of consortia studies. This is a continuation of our strong track record of method development in statistical
genetics. We will implement the methods into a few widely used tools, including RVTESTS, SEQMINER, and
RAREMETAL, which will not only benefit our own study but also other researchers in the field.
摘要
大规模的基因数据集已经彻底改变了人类基因研究。在过去的十年里,
关联研究已经确定了与各种复杂性状相关的许多遗传变异。这些
这些发现为新的生物学提供了信息,并导致了新的治疗方法。然而,大多数研究都集中在欧洲。
大多数研究都是通过将男女样本合并在一起进行的。性别特异性遗传
在不同的人群中的建筑仍然很难理解。作为下一步,财团的努力已经开始,
从不同的非欧洲人口的汇总数据集。荟萃分析通常在大型联合体中使用
研究迫切需要开发能够有效地进行跨祖先Meta研究的方法,
分析.为此,我们将制定一系列创新方法,提高协会的权力
作图、精细作图的精确性和跨祖先分析中多基因预测的准确性。
所得到的方法将应用于一系列心脏,肺和血液相关的性状,与一个合作,
联合研究的数量。这是我们在统计方法开发方面的良好记录的延续
遗传学我们将在一些广泛使用的工具中实现这些方法,包括RVTESTS、SEQMINER和
这不仅有利于我们自己的研究,也有利于该领域的其他研究人员。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
IsoAnalytics: a single-cell proteomics web server.
- DOI:10.1093/bioadv/vbad077
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Palmer, Suzette N.;Koh, Andrew Y.;Zhan, Xiaowei
- 通讯作者:Zhan, Xiaowei
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{{ truncateString('Bibo Jiang', 18)}}的其他基金
Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits
保险索赔的综合基因组和地理空间分析、生物库和复杂性状的 GWAS 汇总统计
- 批准号:
10595104 - 财政年份:2023
- 资助金额:
$ 77.98万 - 项目类别:
Methods to unveil sex-specific genetic architecture in trans-ancestry meta-analysis
在跨祖先荟萃分析中揭示性别特异性遗传结构的方法
- 批准号:
10445464 - 财政年份:2022
- 资助金额:
$ 77.98万 - 项目类别:
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