Multi-site Feasibility of Compassion Meditation for Veterans with PTSD

对患有创伤后应激障碍 (PTSD) 的退伍军人进行同情冥想的多地点可行性

• 批准号: 10681296
• 负责人: Ariel J Lang
• 金额: $ 59.53万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681296
• 关键词: Address; Area; Assessment tool; Behavioral; California; Caring; Clinical; Clinical Trials; Cognitive; Compassion; Complement; Country; Data; Development; Enrollment; Evidence based treatment; Fostering; Future; Glean; Goals; Health; Humanities; Impairment; Individual; Intervention; Investigation; Laboratories; Lead; Link; Manuals; Measures; Mediating; Meditation; Methodology; Military Personnel; Monitor; National Center for Complementary and Integrative Health; Outcome; Patient Self-Report; Personal Satisfaction; Phase; Population; Post-Traumatic Stress Disorders; Preparation; Procedures; Process; Protocols documentation; Randomized; Randomized, Controlled Trials; Recovery; Relaxation; Research; Role; Sampling; Site; Stress; Symptoms; Training; Translating; Veterans; Work; acceptability and feasibility; clinical effect; coping; efficacy trial; interest; multimodality; participant retention; patient response; pilot test; positive emotional state; preference; psychologic; psychosocial; randomized trial; recruit; regional difference; resilience; social; tool; treatment effect

PROJECT SUMMARY/ABSTRACT Posttraumatic stress disorder (PTSD) is a common health concern among Veterans. Although empirically-supported approaches are widely available, engagement rates are low and partial/non response is common. There has been considerable interest in the role of complementary and alternative interventions for PTSD, but little research is available to guide decisions about care. Compassion meditation (CM), a contemplative practice that is intended to foster connectedness with others, shows promise for the treatment of PTSD in Veterans. In healthy populations, CM fosters positive emotion and social connectedness, both of which are known to enhance coping and resilience in the face of extreme stress. Based on this theoretical rationale, we recently completed a two-phase proof of concept trial of CM for Veterans with PTSD. The first phase employed qualitative and quantitative procedures to iteratively refine an existing CM protocol, CBCT® (Cognitively-Based Compassion Training), for Veterans with PTSD. The second phase utilized a pilot randomized controlled trial to establish the feasibility and acceptability of a randomized trial of CM for Veterans with PTSD and to examine potential clinical impact. On the basis of promising results, the proposed project will evaluate the feasibility of a future multi-site efficacy trial of CM for PTSD. Although our prior work is an encouraging first step, key questions remain. First, our data come from a single site in Southern California. It is possible that there are regional differences in the acceptability of CM, so we plan to examine the feasibility of recruiting and retaining Veterans residing in another area as well as confirming the acceptability of the approach to a more diverse sample. Second, our previous trial relied on a single therapist, who was actively engaged in the development process. It is important to demonstrate that others can be trained to deliver the approach with fidelity and to have some confidence that our results are attributable to the protocol rather than to an individual. Finally, in the interest of ultimately understanding the way in which these interventions lead to symptom change, we will continue to refine our assessment strategy, including adding behavioral methodologies to augment what can be gleaned from self-report measures. If successful, this project will lay the necessary groundwork for an efficacy trial of CM, which ultimately could provide an additional evidence-based treatment option for Veterans with PTSD.

项目总结/摘要 创伤后应激障碍（PTSD）是退伍军人中常见的健康问题。虽然 有医疗支持的方法广泛可用，参与率低，部分/无应答率低。 共同人们对补充性和替代性干预措施的作用很感兴趣， 创伤后应激障碍，但很少有研究可用于指导有关护理的决定。Compounds meditation（CM），a 旨在促进与他人联系的预防性实践，显示出治疗 退伍军人的PTSD在健康人群中，CM促进积极情绪和社会联系， 这是众所周知的，以提高应对和弹性，在面对极端的压力。基于这一理论 基于此，我们最近完成了一项两阶段的概念验证试验，即针对患有创伤后应激障碍的退伍军人的CM。第一 阶段采用定性和定量程序，反复完善现有的CM协议，CBCT （认知为基础的Companion培训），为退伍军人与创伤后应激障碍。第二阶段利用了一个试点 一项随机对照试验，旨在确定退伍军人CM随机试验的可行性和可接受性 并检查潜在的临床影响。在取得可喜成果的基础上，拟议项目将 评估未来CM治疗PTSD的多中心疗效试验的可行性。 虽然我们先前的工作是令人鼓舞的第一步，但关键问题仍然存在。首先，我们的数据来自 位于南加州的单一地点。有可能在CM的可接受性方面存在区域差异，因此 我们计划研究招募和留住居住在其他地区的退伍军人的可行性， 证实了该方法对更多样化样本的可接受性。第二，我们之前的审判依赖于 一个治疗师，他积极参与了发展过程。必须证明， 其他人可以接受培训，以忠实地提供方法，并对我们的结果有一定的信心。 归因于协议而不是个人。最后，为了最终理解 这些干预措施导致症状改变的方式，我们将继续完善我们的评估策略， 包括增加行为方法，以扩大什么可以从自我报告的措施收集。如果 如果成功，该项目将为CM的有效性试验奠定必要的基础，最终可以 为患有PTSD的退伍军人提供额外的循证治疗选择。