Admin Core

管理核心

• 批准号: 10681233
• 负责人: DAVID M RAND
• 金额: $ 48.99万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681233
• 关键词: Accountability; Administrative Coordination; Administrative Efficiency; Administrator; Advisory Committees; Award; Bioinformatics; Biological; Biology; Biomedical Research; Centers of Research Excellence; Collaborations; Communication; Communities; Computational Biology; Computational Molecular Biology; Computer Analysis; Computers; Data; Data Scientist; Dedications; Discipline; Effectiveness; Engineering; Ensure; Evaluation; Evaluation Reports; Faculty; Funding; Future; Genomics; Goals; Grant; High Performance Computing; Hospitals; Human Biology; Individual; Infrastructure; Investments; Joints; Lead; Leadership; Learning; Life Cycle Stages; Medicine; Mentors; Methods; Office of Administrative Management; Peer Review; Phase; Pilot Projects; Program Evaluation; Program Sustainability; Public Health; Reporting; Research; Research Personnel; Research Project Grants; Resources; Schedule; Schools; Science; Services; Strategic Planning; Structure; Support Groups; Time; Universities; Visualization; biomedical informatics; career; career development; community building; computer science; computing resources; cost; faculty support; genomic data; human disease; interest; meetings; programs; recruit; skills; statistical center; success

PROJECT SUMMARY The goal of this Phase 2 COBRE for Computational Biology of Human Disease (CBHD) is to strengthen, expand, and sustain research programs focusing on computational approaches to the basic biology of human diseases. This involves support for faculty investigators that increases their competitiveness for peer-reviewed funding, as well as support for resources and infrastructure that enhances Brown’s broader biomedical research community. A key theme of this Center is to build upon the strengths of biomedical researchers whose individual questions may differ widely, but whose underlying analytical questions share common ground in computational analyses of large-scale genomic datasets that lead to discovery. The Administrative Core will lead, coordinate, and manage 1) the general activities of the Center including strategic planning, advisory committee meetings, fiscal accountability, regulatory compliance, communication, and reporting; 2) the career development activities of the junior investigators including the Research Projects and Pilot Project programs, mentoring activities, and the Computational Biology Core resource, and 3) activities that strengthen program sustainability including strategic partnerships, program integration, community building, program evaluation, and cost-center planning. The Administrative Core in Phase 2 will build upon the resources and infrastructure developed and implemented in Phase 1 with proven effectiveness. Brown University has invested heavily in facilities that generate data (e.g., the Genomics Core), the Center for Computation and Visualization (CCV) that maintains the super computer and staffs the Advanced Research Computing group that supports high performance computing, and research centers with targeted academic interests in biology and medicine. Our CBHD COBRE is distinct from research centers as the sole service Center focused on analysis of omics-enabled data. We will achieve the goals of strengthening and sustaining the COBRE in Phase 2 with the following Specific Aims. 1. Provide scientific leadership, administrative coordination, and fiscal management to support the continued integration, expansion and strengthening of the Center. 2. Provide junior faculty Project Leaders with research funding, career development mentoring, and computational resources to strengthen research competitiveness and achieve peer-reviewed, sustainably funded research programs. 3. Facilitate and ensure Center sustainability and responsiveness by integrative community building, establishing strategic collaborative partnerships, and responding to formative and summative program evaluation.

项目概要 人类疾病计算生物学 (CBHD) 第二阶段 COBRE 的目标是加强、扩展、 并维持以人类疾病基础生物学计算方法为重点的研究项目。 这涉及对教师研究人员的支持，以提高他们在同行评审资金方面的竞争力，因为 以及对资源和基础设施的支持，以增强布朗更广泛的生物医学研究社区。 该中心的一个关键主题是利用生物医学研究人员的优势，他们的个人问题 可能差异很大，但其基本分析问题在计算分析中具有共同点 导致发现的大规模基因组数据集。行政核心将领导、协调和 管理 1) 中心的一般活动，包括战略规划、咨询委员会会议、财务 问责制、监管合规性、沟通和报告； 2）职业发展活动 初级研究人员，包括研究项目和试点项目计划、指导活动以及 计算生物学核心资源，以及 3) 加强计划可持续性的活动，包括战略 伙伴关系、项目整合、社区建设、项目评估和成本中心规划。这 第二阶段的行政核心将建立在开发和实施的资源和基础设施的基础上 第一阶段已被证实有效。布朗大学在生成数据的设施上投入了大量资金（例如， 基因组核心），维护超级计算机的计算和可视化中心（CCV） 并为高级研究计算小组提供支持高性能计算和研究的人员 在生物学和医学方面有针对性的学术兴趣的中心。我们的 CBHD COBRE 与研究不同 中心作为唯一的服务中心，专注于组学数据分析。我们将实现以下目标 在第二阶段加强和维持 COBRE，具体目标如下。 1.提供科学的 领导、行政协调和财政管理，以支持持续整合、扩张 并加强中心的建设。 2. 为初级教师项目负责人提供研究经费、职业生涯 发展指导和计算资源，以增强研究竞争力并实现 同行评审、可持续资助的研究项目。 3. 促进并确保中心的可持续性 通过综合社区建设、建立战略合作伙伴关系来提高响应能力，以及 回应形成性和总结性计划评估。