Administrative Core

摘要/摘要 人类疾病的遗传基础一直是生物医学科学的潜在焦点， 几乎一个世纪，是人类基因组计划背后的主要推动因素。与 基因组数据的爆炸带来了个性化医疗的时代， 计算分析对于所有形式的调查都变得至关重要。越来越多的临床医生和 基础科学家面临着包含重要答案的大量基因组数据集 医学问题，但发现受到有限的计算专业知识的阻碍。眼镜蛇 人类疾病计算生物学中心旨在拥抱这个时代， 基因组医学从明确计算的角度。五名初级调查员将领导 研究项目集中在不同的疾病，如癌症，呼吸和年龄- 相关疾病和先兆子痫，但由共同的计算和生物信息学联合起来， 大型基因组数据集的挑战。通过建立一个经验和 计算科学家，我们将能够推进新的发现，算法和遗传 以及与几种人类疾病直接相关的基因组筛选方法。的 该中心的相关行政核心将为这些活动提供强有力的支持。 具体的研究项目，同时也提供了支持的增长广泛的基础， 布朗大学及其附属医院在人类疾病方面的合作研究工作。

Summary/Abstract The genetic basis of human disease has been an underlying focus the biomedical sciences for almost a century, and was a major motivating factor behind the human genome project. With the explosion of genomic data that has brought on the age of personalized medicine, the role of computational analyses has become critical for all forms of inquiry. Increasingly, clinicians and basic scientists are confronted with massive genomic data sets that contain important answers to medical problems, but discovery is hindered by limited computational expertise. The COBRE Center for Computational Biology of Human Disease is intended to embrace this age of genomic medicine from an explicitly computational angle. Five Junior Investigators will lead research projects on that focus on different diseases such as cancer, respiratory and age- related diseases and preeclampsia, but are united by common computational and bioinformatic challenges of large genomic data sets. By building a collaborative Center of empirical and computational scientists, we will be able to advance new discoveries, algorithms and genetic and genomic screening approaches with direct relevance to several human diseases. The associated Administrative Core of this Center will provide a strong supportive context for these specific research projects, while also providing a broad base of support for the growth of collaborative research efforts on human disease at Brown University and its Affiliated Hospitals.