In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant
干细胞移植后患者中性粒细胞功能的体内监测
基本信息
- 批准号:10679553
- 负责人:
- 金额:$ 81.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-13 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAntifungal AgentsAzolesBiological MarkersCSF3 geneCandidaCandida albicansCandida aurisCandidiasisCellsCommunicationDiagnosisEarly DiagnosisEffectivenessEngineeringEnrollmentFunctional disorderFungal Drug ResistanceFutureGoalsGrowthHematologic NeoplasmsHematopoietic Stem Cell TransplantationHospitalizationHumanHyphaeImageImaging TechniquesImmune responseIn VitroIndividualInfectionInjuryKnowledgeLabelLeukocytesLifeMalignant NeoplasmsMeasurementMeasuresMicroscopicMolecularMonitorMorbidity - disease rateMycosesOutcomePatientsPerformancePhagocytosisPopulationPredispositionProceduresProphylactic treatmentRecoveryResearchResistanceRiskRisk EstimateRisk FactorsRisk ReductionRoleSiteStem cell transplantTechniquesTherapeuticTimeTransplant RecipientsTransplantationaccurate diagnosiscandidemiachemokinecytokinedesignfirst responderfunctional restorationfungushigh riskhuman imagingimprovedimproved outcomein vivoin vivo monitoringinfection riskleukemiamortalityneutrophilnovel imaging technologypatient stratificationpost-transplantrestorationtissue injurytool
项目摘要
Hematopoietic stem cell transplant (HSCT), an essential procedure in the treatment of patients with
hematological malignancies, also temporarily increases the risk for infections with invasive fungi. The recovery
in the neutrophil number after HSCT is commonly regarded as a key metric for the restoration of antifungal
defenses. However, the metric is imprecise, and there is an urgent need for new biomarkers to help identify the
patients at risk. In the absence of new tools, the management of invasive fungal infections remains remarkably
challenging. The long-term goal of this research is to engineer new tools and validate new metrics estimating
the risk for invasive fungal infections in HSCT patients. Achieving this goal requires a focus on neutrophil
swarming function, which is critical in effective antifungal immune responses. Swarming is distinct from
phagocytosis in that it involves neutrophil-neutrophil communication that helps coordinate the activities of
multiple cells toward blocking the growth of invasive fungi. The focus on neutrophil swarming is justified by
preliminary results showing that in HSCT patients, even when the neutrophil count recovered at 4 weeks after
transplant, a neutrophil swarming deficiency is still present and is substantial. Knowledge about how neutrophil
swarming deficiency is resolved over time after HSCT is currently lacking. To address this knowledge gap and
evaluate the utility of new biomarkers we will pursue the following specific aims: 1) Determine neutrophil
swarming parameters that are distinct in healthy and HSCT patients. 2) Determine what cytokines help restore
the swarming activity of neutrophils from HSCT patients and 3) Design new imaging techniques for label-free
tracking of human neutrophils responding to microscopic tissue injuries in vivo. If successful, the proposed
research could have a major impact on the lives of HSCT patients by improving the monitoring of their recovery
and by identifying potential strategies for accelerating the recovery of their neutrophil functions and improving
their protection against fungal infections.
造血干细胞移植(HSCT)是治疗多发性硬化症患者的重要程序
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Daniel Irimia其他文献
Daniel Irimia的其他文献
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{{ truncateString('Daniel Irimia', 18)}}的其他基金
Microfluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood during Acute Lyme Disease
用于探测急性莱姆病期间血液中中性粒细胞与疏螺旋体相互作用的微流控分析
- 批准号:
10379279 - 财政年份:2021
- 资助金额:
$ 81.7万 - 项目类别:
Microfluidic Assessment of Clinical Outcomes in Preterm Newborns
早产儿临床结果的微流控评估
- 批准号:
10164831 - 财政年份:2017
- 资助金额:
$ 81.7万 - 项目类别:
Transient Obstruction of Capillary Networks by Chromatin Yarns from Neutrophils in Older Adults
老年人中性粒细胞染色质纱线对毛细血管网络的短暂阻塞
- 批准号:
8953369 - 财政年份:2015
- 资助金额:
$ 81.7万 - 项目类别:
Microfluidic tools for probing neutrophil reversed migration
用于探测中性粒细胞反向迁移的微流体工具
- 批准号:
9096701 - 财政年份:2015
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
9897528 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
10379440 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
7859917 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
8068338 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
8258312 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
Neutrophil Decision Making in Confined Environments in Health and Disease
健康和疾病中受限环境中的中性粒细胞决策
- 批准号:
8463563 - 财政年份:2010
- 资助金额:
$ 81.7万 - 项目类别:
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