High-resolution flexible mobility analyzer for point-of-care diagnostics

用于现场诊断的高分辨率灵活移动分析仪

• 批准号: 10701671
• 负责人: Yehia Ibrahim
• 金额: $ 24.64万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-10 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10701671
• 关键词: Address; Area; Atmospheric Pressure; Bacteria; Biological; Biological Markers; Blood; Cell membrane; Cell physiology; Cellular Structures; Charge; Chemicals; Decision Making; Detection; Devices; Disease; Disease Marker; Disease Outbreaks; Disease Progression; Drops; Electrodes; Electrospray Ionization; Emergency Situation; Evaluation; Evolution; Fatty Acids; Geometry; Goals; Health; Healthcare; Individual; Ions; Laboratories; Length; Lipids; Mass Fragmentography; Miniaturization; Molecular; Monitor; Participant; Patients; Performance; Play; Point of Care Technology; Resolution; Role; Rotation; Saliva; Sampling; Security; Shapes; Specificity; Spectrometry; Speed; Technology; Theoretical model; Time; Work; cost; design; disease diagnostic; electric field; empowerment; experience; experimental study; flexibility; health management; improved; instrument; instrumentation; ion mobility; ion source; lens; mass spectrometer; miniaturize; miniaturized device; mobility aid; molecular marker; novel; pathogen; personalized medicine; point of care; point-of-care diagnostics; portability; prototype; simulation; transmission process; voltage

PROJECT SUMMARY This project aims to address the current gap in technology for rapid lipids profiling. A point-of-care technology that provides quick detection will impact healthcare management by leveraging patient’s proactive participation. In pursuance of this goal, we will develop an ion mobility chemical analysis technology, which provides chemical information with molecular level specificity, for disease diagnostics and monitoring and identification of pathogens. The project will focus on a proof-of- concept technology for a portable molecular analyzer device that can be utilized to analyze breath, saliva, blood pricks in its mature stage for markers of disease. The new device will be designed based on extensive ion trajectory simulations that will provide the geometrical as well as optimal operating parameters. Optimal designs will be used to build prototypes that will be evaluated in terms of sensitivity and selectivity for detecting targeted molecules to demonstrate a working prototype in conjunction with a mass spectrometer.

项目总结 该项目旨在解决目前在快速脂类分析技术方面的差距。护理点 提供快速检测的技术将通过利用患者的 积极参与。为了实现这一目标，我们将开发一种离子迁移率化学分析 为疾病提供具有分子水平特异性的化学信息的技术 病原体的诊断、监测和鉴定。该项目将专注于证明- 可用于分析呼吸的便携式分子分析仪设备的概念技术， 唾液、血液在成熟阶段刺痛，是疾病的标志。新的设备将被设计成 基于广泛的离子轨迹模拟，将提供几何和最佳 运行参数。将使用最优设计来构建原型，这些原型将被评估为 检测目标分子的灵敏度和选择性，以演示工作原型 与质谱仪结合使用。