Regulated cell death and responses to starvation in cancer

摘要 细胞对压力的反应是通过上调促进生存的适应机制， 当压力过大时细胞会死亡。癌细胞利用压力 为了在严酷的癌症微环境中生存， 利用适应机制来避免细胞死亡对于获得新的知识至关重要， 用于癌症治疗也变得很清楚的是，不是一个，而是事实上有很多 不同形式的细胞死亡，可以发生在应对压力，我们的研究已经作出了贡献， 在这方面意义重大。我们已经证明，某些机制对 细胞群体的动力学，一些促进，而另一些可能阻碍， 应答我们提出的研究计划将集中在两个主要领域的发现：（1）如何 细胞死亡是否受应激反应的调节，以及特定的机制是如何促成 控制人口动态(2)细胞如何通过适应性反应来应对营养饥饿 与溶酶体有关的机制我们将利用最近的发现和方法， 通过一套完整的细胞生物学方法来研究这些首要问题。 方法，重点是基于成像的研究。

Abstract Cells respond to stress by upregulating adaptive mechanisms that promote survival or by undergoing cell death when the stress is too severe. Cancer cells take advantage of stress responses in order to survive within harsh cancer microenvironments, and understanding which adaptive mechanisms are utilized to avoid cell death is critical to gaining new knowledge that may be exploited for cancer therapy. It has also become clear that there is not one, but in fact many different forms of cell death that can occur in response to stress, and our studies have contributed significantly in this area. We have shown that some mechanisms have unique effects on the dynamics of cell populations, and that some promote, while others may hinder, therapeutic responses. Our proposed research program will focus on two major areas of discovery: (1) How is cell death regulated in response to stress, and how do particular mechanisms contribute to controlling population dynamics? (2) How do cells respond to nutrient starvation through adaptive mechanisms that involve lysosomes? We will exploit recent findings and methods we have developed to study these overarching questions through an integrated set of cell biological approaches with a focus on imaging-based studies.