权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Administrative Core

行政核心

基本信息

批准号：
10701908
负责人：
GEORGE A KUCHEL
金额：
$ 88.96万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701908
关键词：
Achievement Address Adipose tissue Age Aging Area Biological Biological Markers Biology Boston Calibration Cell Aging Clinic Clinical Trials Collaborations Data Data Analyses Diabetes Mellitus Discipline Discipline of obstetrics Endocrinology Ensure Ethnic Origin Evaluation Follow-Up Studies Future Generations Genomic medicine Geriatrics Geroscience Goals Gynecology Health Heterogeneity Hospitals Human Individual Institution Kidney Laboratories Leadership Maps Nephrology Pancreas Phase Phenotype Placenta Population Productivity Program Evaluation Qualitative Research RLK5-associated protein phosphatase Race Ramp Research Research Activity Research Design Research Personnel Resource Allocation Resources Sample Size Sampling Services Site Skin Skin Tissue Spatial Distribution Surveys Thick Tissues Transplantation Surgery United States National Institutes of Health Woman Work clinically relevant human subject human tissue innovation insight multidisciplinary novel programs scale up senescence sex single cell technology skills tissue mapping

项目摘要

The Administrative Core will coordinate and oversee all research activities across KAPP-Sen TMC Collaborative sites in support of SenNet goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas, and placenta. Efforts will be made to ensure ongoing robust and productive dialogue and input from KAPP-Sen TMC investigators and staff with varied relevant areas of scientific expertise, disciplinary backgrounds, and perspectives. Moreover, continued innovation will be pursued by leveraging the ability of investigators from across SenNet to provide unique cutting-edge novel insights arising from their individual disciplines. The Core will also participate in ongoing program evaluation using both informal strategies and the established capacities of the UConn Center on Aging Evaluation and Population Assessment Research Core to perform rigorous program evaluation throughout KAPP-Sen and of Sen-Net partners as a means of ensuring the achievement of our objectives and pre-defined metrics, thus enabling optimal allocation of resources. Core leadership and staff will also collaborate with NIH staff and other SenNet leaders in ensuring the successful implementation of an innovative Phased Adaptive Approach to study design and data analysis, thereby providing a rational path from an Initial Data Generation Phase to an Interim Evaluation and Recalibration Phase leading ultimately to the Study Full Scale-Up and Completion Phase.

行政核心将协调和监督KAPP森TMC的所有研究活动支持SenNet目标的合作网站，以绘制细胞衰老及其相关的在健康人的肾脏、脂肪组织、胰腺和胎盘中的分泌表型。着力确保KAPP-Sen TMC调查人员和工作人员持续进行强有力和富有成效的对话和投入具有不同的相关领域的科学专业知识，学科背景和观点。此外，委员会认为，将通过利用SenNet的调查人员的能力来追求持续的创新，独特的前沿新颖的见解，从他们各自的学科产生。核心小组还将利用非正式战略和既定的康州大学老龄化评估和人口评估研究中心的能力，以执行在KAPP-Sen和Sen-Net合作伙伴中进行严格的计划评估，以确保实现我们的目标和预定义的指标，从而实现资源的最佳分配。核心领导层和工作人员还将与NIH工作人员和其他SenNet领导人合作，确保成功实施创新的分阶段自适应方法来研究设计和数据分析，从而提供从初始数据生成阶段到中期评估的合理路径，重新校准阶段，最终导致研究全面扩大和完成阶段。