Administrative Core

行政核心将协调和监督Kapp-Sen TMC的所有研究活动 支持绘制细胞衰老及其相关的Sennet目标的协作站点 健康人肾脏、脂肪组织、胰腺和胎盘的分泌表型。我们将努力 确保Kapp-Sen TMC调查人员和工作人员持续进行有力和富有成效的对话和投入 具有不同的科学专长、学科背景和视角的相关领域。此外， 将通过利用来自Sennet的调查人员的能力来追求持续创新 独特的前沿小说洞察力来自于各自的学科。 核心还将使用非正式战略和既定战略参与正在进行的方案评估 康涅狄格州老龄评估和人口评估研究中心的执行能力 对整个Kapp-Sen和Sen-Net合作伙伴进行严格的计划评估，以确保 实现我们的目标和预定义的指标，从而实现资源的最佳分配。 核心领导层和员工还将与NIH员工和其他Sennet领导人合作，确保 成功实施创新的分阶段自适应方法来研究设计和数据分析， 从而提供了从初始数据生成阶段到中期评估的合理路径 重新校准阶段最终导致研究的全面扩大和完成阶段。

The Administrative Core will coordinate and oversee all research activities across KAPP-Sen TMC Collaborative sites in support of SenNet goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas, and placenta. Efforts will be made to ensure ongoing robust and productive dialogue and input from KAPP-Sen TMC investigators and staff with varied relevant areas of scientific expertise, disciplinary backgrounds, and perspectives. Moreover, continued innovation will be pursued by leveraging the ability of investigators from across SenNet to provide unique cutting-edge novel insights arising from their individual disciplines. The Core will also participate in ongoing program evaluation using both informal strategies and the established capacities of the UConn Center on Aging Evaluation and Population Assessment Research Core to perform rigorous program evaluation throughout KAPP-Sen and of Sen-Net partners as a means of ensuring the achievement of our objectives and pre-defined metrics, thus enabling optimal allocation of resources. Core leadership and staff will also collaborate with NIH staff and other SenNet leaders in ensuring the successful implementation of an innovative Phased Adaptive Approach to study design and data analysis, thereby providing a rational path from an Initial Data Generation Phase to an Interim Evaluation and Recalibration Phase leading ultimately to the Study Full Scale-Up and Completion Phase.