Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

这个项目将研究在慢性疼痛和心血管疾病等疾病中发挥主要作用的一个重要蛋白质家族的性质。它将应用多学科、尖端的方法来了解不同类型的药物如何作用于这些蛋白质，并利用这些信息开发能够以更有选择性和更有效的方式调节这些蛋白质的新药物线索，特别强调针对慢性疼痛情况。

This project will investigate the properties of an important family of proteins that play a major role in diseases such as chronic pain and cardiovascular illnesses. It will apply multidisciplinary, cutting-edge, approaches to understand how different types of drugs act on these proteins, and use this information to develop novel drug leads that can modulate these proteins in a more selective and efficacious manner, with a particular emphasis on targeting chronic pain conditions.