Understanding mechanisms of allostery and biased agonism at the adenosine A1 receptor

了解腺苷 A1 受体的变构和偏向激动机制

• 批准号: nhmrc : 1084246
• 负责人: Dr Daniel Scott
• 金额: $ 40.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-mechanisms-allostery-a1-receptor/518989
• 关键词: Understanding; mechanisms; allostery; biased; agonism

This project focuses on an important protein found in the heart. Drugs that activate this protein can protect the heart against damage that occurs after a heart attack, but they all have undesirable side effects. We have discovered a new class of molecule that can protect the heart without these side effects. We now seek to understand how these compounds work at the molecular level. This knowledge can facilitate the design of safer medicines for the treatment of cardiovascular disease.

该项目重点关注心脏中发现的一种重要蛋白质。激活这种蛋白质的药物可以保护心脏免受心脏病发作后的损害，但它们都有不良副作用。我们发现了一类新的分子，可以保护心脏而没有这些副作用。我们现在寻求了解这些化合物如何在分子水平上发挥作用。这些知识可以促进设计更安全的治疗心血管疾病的药物。