STABILISING G PROTEIN-COUPLED RECEPTORS FOR DRUG DISCOVERY

靶向人类蛋白质的处方药称为GPCR，作为许多疾病的有效治疗方法出售。然而，人体中有超过800种不同类型的GPCR，只有一小部分被药物靶向，主要是因为GPCR不稳定，因此难以在实验室中使用。我们正在应用新开发的技术来设计稳定的α1-肾上腺素受体，一类GPCR，用于治疗心血管疾病，癫痫和神经退行性疾病的药物发现

Prescription drugs targeting human proteins called GPCRs are sold as effective treatments for many diseases. However, there are over 800 different types of GPCRs in the human body and only a small fraction is targeted by drugs, mainly because GPCRs are unstable and thus difficult to work with in the laboratory. We are applying newly developed technologies to engineer stabilised α1-adrenoceptors, a class of GPCRs, for drug discovery against cardiovascular diseases, epilepsy and neurodegeneration