Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

腺苷 A1 受体调节：结构、动力学

• 批准号: nhmrc : 1145420
• 负责人: Dr Daniel Scott
• 金额: $ 120.96万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adenosine-a1-receptor-pharmacological-interventions/1320448
• 关键词: Adenosine; A1; receptor; modulation; Structure

This project will investigate the properties of an important family of proteins that play a major role in diseases such as chronic pain and cardiovascular illnesses. It will apply multidisciplinary, cutting-edge, approaches to understand how different types of drugs act on these proteins, and use this information to develop novel drug leads that can modulate these proteins in a more selective and efficacious manner, with a particular emphasis on targeting chronic pain conditions.

该项目将研究在慢性疼痛和心血管疾病等疾病中发挥重要作用的重要蛋白质家族的特性。它将应用多学科、尖端的方法来了解不同类型的药物如何作用于这些蛋白质，并利用这些信息开发新的药物先导物，以更有选择性和更有效的方式调节这些蛋白质，特别强调针对慢性疼痛病症。