Multi-Contrast Chest Radiography (MC-CXR) for COVID-19 Diagnosis and Screening

用于 COVID-19 诊断和筛查的多重对比胸部 X 光检查 (MC-CXR)

基本信息

批准号：
10160566
负责人：
Guang-Hong Chen
金额：
$ 40.44万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-08 至 2021-07-07
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10160566
关键词：
Accident and Emergency department Alveolar American College of Radiology Breast Cancer Detection COVID-19 COVID-19 pandemic Case Study Cessation of life Chest China Clinic Clinical Communicable Diseases Communities Computed Tomography Scanners Contrast Sensitivity Country Diagnosis Diagnostic Imaging Diagnostic radiologic examination Disease Early Diagnosis Edema Emergency Situation Employee Environment Exposure to Exudate Goals Gold Health Personnel Health Professional Health care facility Healthcare Systems Hospitals Human Resources Image Imaging Device Imaging technology Infection International Lung Mammography Methods Monitor Pathologic Patients Performance Phase Physical Performance Process Protocols documentation Radiation Radiology Specialty Research Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Risk Roentgen Rays Rural Safety Scanning Sensitivity and Specificity Signal Transduction Site Specificity Specimen Study Subject Symptoms System Technology Testing Thoracic Radiography Time United States X-Ray Computed Tomography absorption accurate diagnosis base contrast imaging diagnosis standard diagnostic accuracy effusion health care service organization human subject imaging facilities imaging system improved parent project prevent prototype radiologist rapid diagnosis respiratory response screening treatment response urgent care

项目摘要

Abstract As of 4/30/2020, the Coronavirus Disease 2019 (COVID-19) has infected more than one million people and caused 60,057 deaths in the United States. Neither the clinical symptoms nor the radiological features of COVID- 19 are specific to the disease, resulting in significant challenges to the screening and early diagnosis of this highly infectious disease. The current gold standard method for COVID-19 diagnosis, the reverse transcriptase polymerase chain reaction (RT-PCR) test, has a relatively long turnaround time. Chest x-ray radiography (CXR) has been widely used in the United States for COVID-19 assessment since the first case reported in the US. However, the major challenge with the use of CXR is its low sensitivity and specificity to COVID-19, which is largely attributed to the lack of x-ray absorption contrast sensitivity to mild alveolar damages in the early phases of COVID-19. In this Emergency Competitive Revision, we offer a quick response to the imperative clinical need to improve the diagnostic accuracy of CXR to COVID-19 by leveraging the multi-contrast x-ray imaging technology developed in our ongoing R01 project (EB020521). In particular, the x-ray dark field contrast mechanism is orders of magnitude more sensitive to partial fillings or collapses of alveoli and thus is expected to offer a significant boost to CXR’s sensitivity to alveolar damage. We will quickly construct a multi-contrast chest x-ray radiography (MC-CXR) system, characterize its physical performance, evaluate its radiation safety, and optimize its scan protocols. Finally, we will conduct a pilot human subject study to collect initial evidence for its clinical value in diagnosing COVID-19. Considering the high likelihood for a second wave of COVID-19, the availability of the proposed MC-CXR system can facilitate the hospital systems to cope with additional rounds of patient surge by providing rapid “entrance” assessment of COVID-19.

抽象的截至2010年4月30日，2019年冠状病毒病（COVID-19）感染了100万以上的人，在美国造成6057人死亡。临床症状和共证的放射学特征既不 19是特定于疾病的，导致筛查和早期诊断面临重大挑战高度传染病。当前用于COVID-19诊断的金标准方法，逆转录酶聚合酶链反应（RT-PCR）测试具有相对较长的周转时间。胸部X射线射线照相（CXR）自从美国报道的第一个案件以来，在美国已广泛用于COVID-19评估。但是，使用CXR的主要挑战是对Covid-19的低灵敏度和特异性，这是在很大程度上归因于对早期阶段中轻度肺泡损伤的X射线滥用对比敏感 Covid-19。在此紧急竞争性修订中，我们对当务之急的临床需求进行快速回应通过利用多对比X射线成像来提高CXR对COVID-19的诊断精度在我们正在进行的R01项目（EB020521）中开发的技术。特别是X射线暗场对比机制是对肺泡的部分填充物或崩溃更敏感的数量级，因此可以预期为了显着提高CXR对肺泡损伤的敏感性。我们将迅速构建一个多对比度胸部X射线射线照相（MC-CXR）系统，表征其身体性能，评估其辐射安全性，并优化其扫描协议。最后，我们将进行一项试验人类学科研究，以收集它在诊断Covid-19中的临床价值。考虑到第二波Covid-19的高可能性，拟议的MC-CXR系统的可用性可以促进医院系统应对额外的回合通过提供COVID-19的快速“入口”评估，患者激增。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Impact of anti-charge sharing on the zero-frequency detective quantum efficiency of CdTe-based photon counting detector system: cascaded systems analysis and experimental validation.

DOI：
10.1088/1361-6560/aab9c9
发表时间：
2018-05-01
期刊：
Physics in medicine and biology
影响因子：
3.5
作者：
Ji X;Zhang R;Chen GH;Li K
通讯作者：
Li K

Potential use of microbubbles (MBs) as contrast material in x-ray dark field (DF) imaging: How does the DF signal change with the characteristic parameters of the MBs?

DOI：
10.1117/12.2216322
发表时间：
2016-03
期刊：
影响因子：
0
作者：
Ran Zhang;Bin Qin;Yongshuai Ge;B. Whiting;Ke Li;F. Villanueva;Guang-Hong Chen
通讯作者：
Ran Zhang;Bin Qin;Yongshuai Ge;B. Whiting;Ke Li;F. Villanueva;Guang-Hong Chen

Analogous Lubberts effect in photon counting detectors.

光子计数探测器中的类似鲁伯特效应。