UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 行政核心
基本信息
- 批准号:10685972
- 负责人:
- 金额:$ 32.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-20 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAnimal ModelBasic ScienceBenchmarkingBiocompatible MaterialsBiological ModelsBiometryBiosensorCell modelChildhoodClinicalClinical DataClinical TrialsCollaborationsCommunitiesCystCystic Kidney DiseasesCystic kidneyData AnalysesDefectDevelopmentDiseaseDisease ProgressionEnsureExperimental DesignsFamilyFutureGenerationsGeneticGenetic MaterialsGenetic ModelsGoalsIn VitroIndividualInformaticsInterdisciplinary StudyKidneyKidney DiseasesLaboratoriesLegalLogisticsMethodologyMissionModelingMutationNational Institute of Diabetes and Digestive and Kidney DiseasesOutcomeOutcomes ResearchPathogenesisPathogenicityPathway interactionsPatientsPharmaceutical PreparationsPhenotypePreclinical TestingProteinsReporterReproducibilityReproducibility of ResultsResearchResearch ActivityResearch PersonnelResource DevelopmentResource SharingResourcesScientistServicesSiteStandardizationStructureSystemTestingTraining and EducationTranslational ResearchValidationVisionWorkclinical practicecost effectiveimprovedin vivoinnovationlongitudinal analysismaterial transfer agreementmembermultidisciplinaryprogramsprotein functionrecruitserial imagingtherapeutic evaluationtreatment strategy
项目摘要
ABSTRACT (ADMINISTRATIVE CORE)
The primary mission of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work
with the PKD Consortium, under the guidance of the U24 Central Coordinating Site (U24-CCS) and
NIDDK, to eliminate obstacles in cystic kidney disease research that are slowing progress toward
the development of improved and innovative treatment strategies for cystic kidney disorders. The UAB-
CCKDCC has assembled a multidisciplinary team of researchers, each with strong research programs, who will
direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The
overarching and collective mission of these Cores is to support, accelerate, and expand basic and translational
research activities being performed by PKD Consortium members. The Center will focus on the development of
resources to analyze cilio-cystic disease protein function, localization, and interactions and to assess how
defects in these functions contribute to the pathogenic mechanisms involved in cyst initiation and progression.
The Center will complete its mission through providing ready access to clinical data and biomaterial from CCKD
patients, through the development and distribution of patient-relevant cell and animal models of CCKD, and
through the development of methodology to utilize these models to ascertain the efficacy of candidate therapies
to slow disease progression using a standardized, cost-effective, and longitudinal imaging and analysis
strategies. The services and resources being made available by the Center along with the integration of our
Cores will expand research activities beyond that capable in most individual laboratories. It will accelerate the
pace of research into causes and possible cures of cystic kidney diseases by providing for high quality, robust,
and reproducible outcomes. These are critically needed to prioritize drugs for future clinical trials to halt PKD and
other cystic kidney disorders.
Essential to fulfilling the mission of the UAB-CKDCC is the Administrative Core. The Administrative Core will
provide for the Center’s overall structure to make sure that each of the Cores is working toward the common
goal of developing better treatments options for CCKD. The Administrative Core will be responsible for financial
and scientific oversight, coordinate efforts to ensure that each Core’s activities are aligned with those of the other
U54-PKD Centers (RTCC), and that the focus of each Core reflects the priorities established by the U24-CCS
and NIDDK. The Administrative Core will establish benchmarks and ensure they are achieved, that Center
resources and services being provided to the PKD Consortium, that they are authenticated, robust, and are
delivered in a timely manner, and are not delayed by material transfer agreements or other legal hurdles.
摘要(管理核心)
UAB儿童囊性肾病核心中心(UAB-CCKDCC)的主要使命是
在U24中央协调中心(U24-CCS)的指导下,与PKD联盟合作,
NIDDK,以消除阻碍囊性肾病研究进展的障碍,
开发针对囊性肾病的改进和创新治疗策略。UAB-
CCKDCC组建了一个多学科的研究团队,每个团队都有强大的研究计划,他们将
指导四个紧密集成的资源和面向服务的核心沿着管理核心。的
这些核心的总体和集体使命是支持、加速和扩展基础和转化
PKD联盟成员正在进行的研究活动。该中心将重点发展
资源来分析纤毛囊性疾病蛋白质的功能,定位和相互作用,并评估如何
这些功能的缺陷导致了囊肿发生和发展的致病机制。
该中心将通过提供随时访问CCKD的临床数据和生物材料来完成其使命
通过开发和分发患者相关细胞和CCKD动物模型,
通过开发利用这些模型的方法来确定候选疗法的疗效
使用标准化的、具有成本效益的纵向成像和分析来减缓疾病进展
战略布局中心沿着提供的服务和资源,
核心将扩大研究活动超出了大多数个别实验室的能力。将加快
通过提供高质量,强大,
和可重复的结果。这些是迫切需要的,以优先考虑未来临床试验的药物,以阻止PKD,
其他囊性肾疾病。
行政核心是履行阿拉伯联合酋长国-刚果民主共和国发展协调委员会使命的关键。行政核心将
提供中心的整体结构,以确保每个核心都朝着共同的目标努力,
目的是为CCKD开发更好的治疗方案。行政核心将负责财务
协调努力,确保每个核心的活动与其他核心的活动保持一致
U 54-PKD中心(RTCC),每个核心的重点反映了U24-CCS确定的优先事项
和NIDDK。行政核心将制定基准并确保实现这些基准,
向PKD联盟提供的资源和服务,它们是经过认证的,健壮的,
及时交付,并且不因材料转让协议或其他法律的障碍而延迟。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bradley K. Yoder其他文献
280: Primary Cilia and Fluid Flow Establish the Orientation of Mitotic Spindles
- DOI:
10.1053/j.ajkd.2010.02.287 - 发表时间:
2010-04-01 - 期刊:
- 影响因子:
- 作者:
Neeraj Sharma;Bradley K. Yoder - 通讯作者:
Bradley K. Yoder
Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice.
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的分离和表征。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:6
- 作者:
W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;Carmen M. Foster;N. Neilsen;R. Woychik;J. E. Wilkinson - 通讯作者:
J. E. Wilkinson
NHE Dysregulation in Cilium Deficient Mouse Renal Principal Cells from orpk Mice
orpk 小鼠纤毛缺陷小鼠肾主细胞 NHE 失调
- DOI:
10.1096/fasebj.21.5.a504 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
D. Olteanu;Bradley K. Yoder;M. O. Bevensee;E. Schwiebert - 通讯作者:
E. Schwiebert
Short Communication Isolation andCharacterization ofLiver Epithelial CellLines fromWild-Type andMutant TgN737RpwMice
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的短通讯分离和表征
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;R. Woychik - 通讯作者:
R. Woychik
emp21/em, emccng1/em, emfoxo3b/em, and emfbxw7/em contribute to emp53/em-dependent cell cycle arrest
EMP21、EMCCNG1、EMFOXO3B和EMFBXW7有助于依赖于P53的细胞周期阻滞。
- DOI:
10.1016/j.isci.2025.112558 - 发表时间:
2025-06-20 - 期刊:
- 影响因子:4.100
- 作者:
Jun Wang;Zhang Li;Holly R. Thomas;Ke Fan;Robert G. Thompson;Yongjie Ma;David Crossman;Bradley K. Yoder;John M. Parant - 通讯作者:
John M. Parant
Bradley K. Yoder的其他文献
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{{ truncateString('Bradley K. Yoder', 18)}}的其他基金
Injury Response Mediated Pathogenesis in Renal Ciliopathies
损伤反应介导的肾纤毛病发病机制
- 批准号:
10571152 - 财政年份:2023
- 资助金额:
$ 32.27万 - 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section
UAB 精密动物模型试点中心 (C-PAM) - 协调部分
- 批准号:
10477302 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10391576 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10507035 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)
- 批准号:
10685971 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)
- 批准号:
10455717 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
- 批准号:
10455721 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10722377 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10310430 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
- 批准号:
10218164 - 财政年份:2020
- 资助金额:
$ 32.27万 - 项目类别:
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