UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)

UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)

• 批准号: 10455717
• 负责人: Bradley K. Yoder
• 金额: $ 76.89万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-20 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10455717
• 关键词: Address; Affect; Animal Model; Autosomal Recessive Polycystic Kidney; Basic Science; Biocompatible Materials; Biological Assay; Cell model; Childhood; Cilia; Clinical; Clinical Data; Clinical Trials; Collaborations; Consumption; Cyst; Cystic Kidney Diseases; Cystic kidney; Data; Defect; Development; Disease; Disease Progression; Ensure; Environment; Etiology; Functional disorder; Future; Generations; Genetic; Genetic Models; Goals; Grant; Heart Diseases; Human; In Vitro; Individual; International; Kidney Diseases; Knowledge; Laboratories; Localized Disease; Meckel-Gruber syndrome; Medical Genetics; Medicine; Methodology; Mission; Modeling; Morbidity - disease rate; Mutation; National Institute of Diabetes and Digestive and Kidney Diseases; Nephronophthisis; Outcome; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Pharmaceutical Preparations; Preclinical Testing; Productivity; Proteins; Reagent; Reporter; Reproducibility; Research; Research Activity; Research Personnel; Resource Development; Resources; Scientist; Seeds; Sensory; Services; Signal Transduction; Site; Standardization; System; Testing; Time; Toxicology; Training; Translational Research; Translations; Validation; Vision; Work; base; cost; cost effective; data repository; effective therapy; genetic information; improved; in vitro Bioassay; in vitro Model; in vivo; innovation; longitudinal analysis; member; mortality; multidisciplinary; next generation; pre-clinical; prevent; programs; protein function; ranpirnase; recruit; repository; screening; serial imaging; therapeutic development; tool; treatment strategy

ABSTRACT (OVERALL) The overarching goal of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work in partnership with the PKD Consortium, under the direction of the U24 Central Coordinating Site (U24-CCS) and NIDDK, to eliminate obstacles in cystic kidney disease related research that are hindering progress toward the development of improved and innovative treatment strategies for cystic kidney disorders. To accomplish this goal, the UAB-CCKDCC has assembled a multidisciplinary team of researchers and clinicians who will direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The collective mission of these Cores is to support, accelerate, and expand basic and translational research activities being performed by PKD Consortium members. The Center will focus on the development of resources to analyze cilio-cystic disease protein function, localization, and interactions and how defects in these functions contribute to the pathogenic mechanisms involved in cyst initiation and progression. The Center will complete its mission through providing ready access to clinical data and biomaterial from CCKD patients, through the development and distribution of patient-relevant cell and animal models of CCKD, and through the development of methodology to utilize these models to ascertain the efficacy of candidate therapies to slow disease progression using a standardized, cost-effective, and longitudinal imaging and analysis strategies. The services and resources being made available by the Center along with the integration between each of the Cores will expand research activities well beyond that capable in most individual laboratories and will accelerate the pace of research into causes and possible cures of cystic kidney diseases by providing for high quality, robust, and reproducible outcomes needed to prioritize drugs for future clinical trials.

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