UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)

UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)

基本信息

  • 批准号:
    10455717
  • 负责人:
  • 金额:
    $ 76.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-20 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT (OVERALL) The overarching goal of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work in partnership with the PKD Consortium, under the direction of the U24 Central Coordinating Site (U24-CCS) and NIDDK, to eliminate obstacles in cystic kidney disease related research that are hindering progress toward the development of improved and innovative treatment strategies for cystic kidney disorders. To accomplish this goal, the UAB-CCKDCC has assembled a multidisciplinary team of researchers and clinicians who will direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The collective mission of these Cores is to support, accelerate, and expand basic and translational research activities being performed by PKD Consortium members. The Center will focus on the development of resources to analyze cilio-cystic disease protein function, localization, and interactions and how defects in these functions contribute to the pathogenic mechanisms involved in cyst initiation and progression. The Center will complete its mission through providing ready access to clinical data and biomaterial from CCKD patients, through the development and distribution of patient-relevant cell and animal models of CCKD, and through the development of methodology to utilize these models to ascertain the efficacy of candidate therapies to slow disease progression using a standardized, cost-effective, and longitudinal imaging and analysis strategies. The services and resources being made available by the Center along with the integration between each of the Cores will expand research activities well beyond that capable in most individual laboratories and will accelerate the pace of research into causes and possible cures of cystic kidney diseases by providing for high quality, robust, and reproducible outcomes needed to prioritize drugs for future clinical trials.
文摘(整体)

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Bradley K. Yoder其他文献

280: Primary Cilia and Fluid Flow Establish the Orientation of Mitotic Spindles
  • DOI:
    10.1053/j.ajkd.2010.02.287
  • 发表时间:
    2010-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Neeraj Sharma;Bradley K. Yoder
  • 通讯作者:
    Bradley K. Yoder
Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice.
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的分离和表征。
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    6
  • 作者:
    W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;Carmen M. Foster;N. Neilsen;R. Woychik;J. E. Wilkinson
  • 通讯作者:
    J. E. Wilkinson
NHE Dysregulation in Cilium Deficient Mouse Renal Principal Cells from orpk Mice
orpk 小鼠纤毛缺陷小鼠肾主细胞 NHE 失调
  • DOI:
    10.1096/fasebj.21.5.a504
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Olteanu;Bradley K. Yoder;M. O. Bevensee;E. Schwiebert
  • 通讯作者:
    E. Schwiebert
Short Communication Isolation andCharacterization ofLiver Epithelial CellLines fromWild-Type andMutant TgN737RpwMice
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的短通讯分离和表征
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;R. Woychik
  • 通讯作者:
    R. Woychik
emp21/em, emccng1/em, emfoxo3b/em, and emfbxw7/em contribute to emp53/em-dependent cell cycle arrest
EMP21、EMCCNG1、EMFOXO3B和EMFBXW7有助于依赖于P53的细胞周期阻滞。
  • DOI:
    10.1016/j.isci.2025.112558
  • 发表时间:
    2025-06-20
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Jun Wang;Zhang Li;Holly R. Thomas;Ke Fan;Robert G. Thompson;Yongjie Ma;David Crossman;Bradley K. Yoder;John M. Parant
  • 通讯作者:
    John M. Parant

Bradley K. Yoder的其他文献

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{{ truncateString('Bradley K. Yoder', 18)}}的其他基金

Injury Response Mediated Pathogenesis in Renal Ciliopathies
损伤反应介导的肾纤毛病发病机制
  • 批准号:
    10571152
  • 财政年份:
    2023
  • 资助金额:
    $ 76.89万
  • 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section
UAB 精密动物模型试点中心 (C-PAM) - 协调部分
  • 批准号:
    10477302
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
  • 批准号:
    10391576
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
  • 批准号:
    10507035
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 行政核心
  • 批准号:
    10685972
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)
  • 批准号:
    10685971
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
  • 批准号:
    10455721
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
  • 批准号:
    10722377
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
  • 批准号:
    10310430
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
  • 批准号:
    10218164
  • 财政年份:
    2020
  • 资助金额:
    $ 76.89万
  • 项目类别:

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