UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)
基本信息
- 批准号:10685971
- 负责人:
- 金额:$ 78.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-20 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAffectAnimal ModelAutosomal Recessive Polycystic KidneyBasic ScienceBiocompatible MaterialsBiological AssayCell modelChildhoodCiliaClinicalClinical DataClinical TrialsCollaborationsConsumptionCystCystic Kidney DiseasesCystic kidneyDataDefectDevelopmentDiseaseDisease ProgressionEnsureEnvironmentEtiologyFunctional disorderFutureGenerationsGeneticGenetic ModelsGoalsGrantHeart DiseasesHumanIn VitroIndividualInstitutionInternationalKidney DiseasesKnowledgeLaboratoriesLocalized DiseaseMeckel-Gruber syndromeMedicineMethodologyMissionModelingMorbidity - disease rateMutationNational Institute of Diabetes and Digestive and Kidney DiseasesNephronophthisisOutcomePathogenesisPathogenicityPathway interactionsPatient EducationPatientsPharmaceutical PreparationsPreclinical TestingProductivityProteinsReagentReporterReproducibilityResearchResearch ActivityResearch PersonnelResource DevelopmentResourcesScientistSensoryServicesSignal TransductionSiteStandardizationSystemTestingTimeToxicologyTrainingTranslational ResearchTranslationsValidationVisionWorkbasecostcost effectivedata repositoryeffective therapygenetic informationimprovedin vitro Bioassayin vitro Modelin vivoinnovationlongitudinal analysismembermortalitymultidisciplinarynext generationpre-clinicalpreventprogramsprotein functionrecruitrepositoryscreeningserial imagingtherapeutic developmenttooltreatment strategy
项目摘要
ABSTRACT (OVERALL)
The overarching goal of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work in
partnership with the PKD Consortium, under the direction of the U24 Central Coordinating Site (U24-CCS) and
NIDDK, to eliminate obstacles in cystic kidney disease related research that are hindering progress toward
the development of improved and innovative treatment strategies for cystic kidney disorders. To accomplish this
goal, the UAB-CCKDCC has assembled a multidisciplinary team of researchers and clinicians who will
direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The
collective mission of these Cores is to support, accelerate, and expand basic and translational research activities
being performed by PKD Consortium members. The Center will focus on the development of resources to
analyze cilio-cystic disease protein function, localization, and interactions and how defects in these functions
contribute to the pathogenic mechanisms involved in cyst initiation and progression. The Center will complete its
mission through providing ready access to clinical data and biomaterial from CCKD patients, through
the development and distribution of patient-relevant cell and animal models of CCKD, and through the
development of methodology to utilize these models to ascertain the efficacy of candidate therapies to slow
disease progression using a standardized, cost-effective, and longitudinal imaging and analysis strategies. The
services and resources being made available by the Center along with the integration between each of the
Cores will expand research activities well beyond that capable in most individual laboratories and will accelerate
the pace of research into causes and possible cures of cystic kidney diseases by providing for high quality,
robust, and reproducible outcomes needed to prioritize drugs for future clinical trials.
摘要(总体)
UAB-儿童囊性肾病核心中心(UAB-CCKDCC)的总体目标是:
在U24中央协调站点(U24-CCS)的指导下,与PKD联盟建立伙伴关系,
NIDDK,以消除阻碍进展的囊性肾病相关研究的障碍,
开发针对囊性肾病的改进和创新治疗策略。为了实现这一
为了实现这一目标,UAB-CCKDCC组建了一个由研究人员和临床医生组成的多学科团队,
指导四个紧密集成的资源和面向服务的核心沿着管理核心。的
这些核心的集体使命是支持、加速和扩大基础研究和转化研究活动
由PKD联盟成员执行。该中心将重点开发资源,
分析纤毛囊性疾病蛋白质的功能,定位和相互作用,以及这些功能的缺陷如何
有助于参与囊肿发生和发展的致病机制。该中心将完成其
使命通过提供随时获取CCKD患者的临床数据和生物材料,
CCKD患者相关细胞和动物模型的开发和分布,并通过
开发利用这些模型的方法,以确定候选疗法的疗效,
使用标准化的、具有成本效益的和纵向的成像和分析策略来监测疾病进展。的
中心沿着提供的服务和资源,
核心将扩大研究活动,远远超出大多数个别实验室的能力,并将加速
通过提供高质量的,
需要稳健和可重复的结果来优先考虑未来临床试验的药物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bradley K. Yoder其他文献
280: Primary Cilia and Fluid Flow Establish the Orientation of Mitotic Spindles
- DOI:
10.1053/j.ajkd.2010.02.287 - 发表时间:
2010-04-01 - 期刊:
- 影响因子:
- 作者:
Neeraj Sharma;Bradley K. Yoder - 通讯作者:
Bradley K. Yoder
Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice.
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的分离和表征。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:6
- 作者:
W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;Carmen M. Foster;N. Neilsen;R. Woychik;J. E. Wilkinson - 通讯作者:
J. E. Wilkinson
NHE Dysregulation in Cilium Deficient Mouse Renal Principal Cells from orpk Mice
orpk 小鼠纤毛缺陷小鼠肾主细胞 NHE 失调
- DOI:
10.1096/fasebj.21.5.a504 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
D. Olteanu;Bradley K. Yoder;M. O. Bevensee;E. Schwiebert - 通讯作者:
E. Schwiebert
Short Communication Isolation andCharacterization ofLiver Epithelial CellLines fromWild-Type andMutant TgN737RpwMice
野生型和突变型 TgN737Rpw 小鼠肝上皮细胞系的短通讯分离和表征
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
W. Richards;Bradley K. Yoder;R. J. Isfort;P. G. Detilleux;R. Woychik - 通讯作者:
R. Woychik
emp21/em, emccng1/em, emfoxo3b/em, and emfbxw7/em contribute to emp53/em-dependent cell cycle arrest
EMP21、EMCCNG1、EMFOXO3B和EMFBXW7有助于依赖于P53的细胞周期阻滞。
- DOI:
10.1016/j.isci.2025.112558 - 发表时间:
2025-06-20 - 期刊:
- 影响因子:4.100
- 作者:
Jun Wang;Zhang Li;Holly R. Thomas;Ke Fan;Robert G. Thompson;Yongjie Ma;David Crossman;Bradley K. Yoder;John M. Parant - 通讯作者:
John M. Parant
Bradley K. Yoder的其他文献
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{{ truncateString('Bradley K. Yoder', 18)}}的其他基金
Injury Response Mediated Pathogenesis in Renal Ciliopathies
损伤反应介导的肾纤毛病发病机制
- 批准号:
10571152 - 财政年份:2023
- 资助金额:
$ 78.67万 - 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section
UAB 精密动物模型试点中心 (C-PAM) - 协调部分
- 批准号:
10477302 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10391576 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10507035 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 行政核心
- 批准号:
10685972 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC)
- 批准号:
10455717 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
- 批准号:
10455721 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10722377 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
Intravital analysis of cilia function during injury in the kidney
肾脏损伤期间纤毛功能的活体分析
- 批准号:
10310430 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 体内生物测定和模型开发资源
- 批准号:
10218164 - 财政年份:2020
- 资助金额:
$ 78.67万 - 项目类别:
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