Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for Epilepsy
Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for Epilepsy
批准号:
10686306
负责人:
JOHN D ROLSTON
金额:
$19.23万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-30 至 2024-08-31
关键词:
AccelerationAffectAreaAxonBrainBrain MappingBrain regionCharacteristicsClinicalComputer ModelsComputer softwareComputersDataDiffuseDiffusion Magnetic Resonance ImagingDistantDoctor of PhilosophyElectric StimulationElectrical Stimulation of the BrainElectrocorticogramElectrodesElementsEpilepsyEvoked PotentialsFDA approvedFreedomFrequenciesHumanImageImplantImplanted ElectrodesIndividualIndustryIntractable PainKnowledgeLanguageLeadLinkLocationMapsMental DepressionMental disordersMentorsModelingMonitorMorbidity - disease rateMotorNetwork-basedNeurologic DeficitNeurosurgeonOperative Surgical ProceduresOutcomePathway interactionsPatient-Focused OutcomesPatientsPhysiologic pulsePhysiologyPostdoctoral FellowResearchResearch PersonnelResidenciesResolutionRestSafetyScientistSeizuresSiteSoftware EngineeringStimulusSystemTechnologyTestingTissuesTrainingUniversitiesUtahWorkcareerdensitydesignexperimental studyimprovedinsightmulti-electrode arraysmultimodalityneuroimagingneuroregulationneurosurgerynovelpatient populationpost-doctoral trainingpredicting responseprogramsprospectiveresponsesensory cortexskill acquisitionskillsstructural imagingtooltractographywhite matter
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
Direct cortical stimulation of the brain is used to treat epilepsy and map brain function during surgery.
Yet few patients are free of seizures with this treatment, and morbidity occurs despite ostensibly adequate
mapping. When cortical stimulation is used, it is assumed that the area nearby the electrode, within a few
centimeters, is most affected. But our prior work shows that stimulation evokes widespread effects in distant
regions of the brain. Understanding these network effects will be key in improving our use of brain stimulation.
Using patients with electrodes implanted in the brain for epilepsy treatment, I will investigate cortical
stimulation by 1) using resting-state functional connectivity to predict evoked potential characteristics, 2) using
detailed computer models of patient brains to predict the responses of stimulation, and 3) correlating the
networks activated by stimulation with patient outcomes following NeuroPace Responsive Neurostimulator
placement.
I am a practicing neurosurgeon and neuroscientist with a career devoted to understanding electrical
stimulation of the brain. I was trained as a computer scientist and have relied heavily on this skillset during my
PhD and post-doctoral training. For my PhD, I designed the hardware and software for a closed-loop
neurostimulator, and applied this system to epilepsy research. During my post-doc and residency in
neurosurgery, I studied the basis of electrical stimulation mapping using high-density electrocorticography.
While in industry, I worked as lead software engineer for a company designing closed-loop
stimulation/recording technology for multielectrode arrays. Now, as a functional neurosurgeon, I use
multielectrode stimulation and recording daily in my patients.
Network imaging and computer modeling of stimulation will provide new ways to understand and
restore brain function. Such modeling goes beyond the empirical data that most researchers collect, and that
most of my prior research has focused on. To develop these models, I will work with an expert in
neuromodulation modeling, Dr. Christopher Butson, at the University of Utah. I will acquire these skills through
hands-on training, didactic coursework, and intensive mentoring. At the end of my training, my hope is to
create an independent research program to further link brain stimulation with an understanding of brain
networks, and use these insights to improve the safety and efficacy of the direct cortical stimulation I use in my
patients.
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Asleep Deep Brain Stimulator Placement in the Intraoperative Magnetic Resonance Imaging System Hybrid Operating Suite: 2-Dimensional Operative Video.
术中磁共振成像系统混合手术套件中放置睡眠深部脑刺激器:二维手术视频。
DOI:
10.1093/ons/opaa337
发表时间:
2021
期刊:
Operative neurosurgery (Hagerstown, Md.)
影响因子:
--
作者:
[Brock,AndreaA, Kundu,Bornali, Rolston,JohnD]
通讯作者:
Rolston,JohnD
DOI:
10.1007/s12028-021-01227-y
发表时间:
2021-07
期刊:
Neurocritical care
影响因子:
3.5
作者:
[Edlow BL, Sanz LRD, Polizzotto L, Pouratian N, Rolston JD, Snider SB, Thibaut A, Stevens RD, Gosseries O, Curing Coma Campaign and its contributing members]
通讯作者:
Curing Coma Campaign and its contributing members
Stereotactic Electroencephalography Is Associated With Reduced Pain and Opioid Use When Compared with Subdural Grids: A Case Series.
与硬膜下网格相比,立体定向脑电图与减少疼痛和阿片类药物的使用有关:案例系列。
DOI:
10.1093/ons/opab040
发表时间:
2021
期刊:
Operative neurosurgery (Hagerstown, Md.)
影响因子:
--
作者:
[Scoville,JonathanP, Joyce,Evan, Hunsaker,Joshua, Reese,Jared, Wilde,Herschel, Arain,Amir, Bollo,RobertL, Rolston,JohnD]
通讯作者:
Rolston,JohnD
DOI:
10.1002/acn3.51701
发表时间:
2023-01
期刊:
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
影响因子:
5.3
作者:
[Kundu, Bornali, Arain, Amir, Davis, Tyler, Charlebois, Chantel M., Rolston, John D.]
通讯作者:
Rolston, John D.
DOI:
10.1016/j.wneu.2020.04.001
发表时间:
2020-07
期刊:
World neurosurgery
影响因子:
2
作者:
[Holste K, Sahyouni R, Teton Z, Chan AY, Englot DJ, Rolston JD]
通讯作者:
Rolston JD
共 7 条
Patient-specific modeling and network perturbation to enhance the predictability of direct cortical stimulation for epilepsy
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批准号:10023213
-
项目类别:
-
资助金额:$19.23万
-
财政年份:2019
-
负责人:JOHN D ROLSTON
-
依托单位:
Propagation patterns of microelectrode-recorded human interictal discharges
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批准号:9807847
-
项目类别:
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资助金额:$42.68万
-
财政年份:2019
-
负责人:JOHN D ROLSTON
-
依托单位:
Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for Epilepsy
-
批准号:10887865
-
项目类别:
-
资助金额:$19.23万
-
财政年份:2019
-
负责人:JOHN D ROLSTON
-
依托单位:
Patient-specific modeling and network perturbation to enhance the predictability of direct cortical stimulation for epilepsy
-
批准号:10247063
-
项目类别:
-
资助金额:$19.23万
-
财政年份:2019
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负责人:JOHN D ROLSTON
-
依托单位:
High-density electrocorticography to understand cortical speech arrest sites
-
批准号:8718517
-
项目类别:
-
资助金额:$5.7万
-
财政年份:2015
-
负责人:JOHN D ROLSTON
-
依托单位:
Closed-loop distributed microstimulation for epilepsy
-
批准号:7544390
-
项目类别:
-
资助金额:$2.82万
-
财政年份:2008
-
负责人:JOHN D ROLSTON
-
依托单位:
Closed-loop distributed microstimulation for epilepsy
-
批准号:7689173
-
项目类别:
-
资助金额:$2.89万
-
财政年份:2008
-
负责人:JOHN D ROLSTON
-
依托单位:
海外基金