Clinical and Translational Research Core

P30支持的DartCF临床和翻译研究核心(CTRC)的使命是增加 囊性纤维性疾病及其治疗研究中的翻译研究 胃肠道和肺以外的器官系统。中国红十字会支持基础科学 研究人员和内科科学家通过便利获取和分析来自 囊性纤维化患者和对照人群。反恐委员会在以下各方面提供援助 以人体为研究对象的研究包括研究设计和批准、实施和分析。在……里面 此外，通过充当中央信息交换中心，CTRC致力于协调我们基于临床的 研究将患者群体和临床护理团队的负担降至最低，并最大限度地利用科学 冲击力。采集的样本包括粪便、血清、尿液、纯化的免疫细胞、临床细菌和真菌 根据IRB批准的方案，从患者样本和伴随的患者数据中分离出。这个 CTRC能够收集患者样本，作为纵向和横断面研究的一部分；纵向 将样本与患者健康指标配对的研究对于分析尤为重要 胃肠道微生物区系对预后的影响。反恐委员会制定了一系列 储存的样本用于快速假设检验，这一资源对于获得 新研究的初步数据。达特茅斯及其合作伙伴的所有CF研究人员都可以使用CTRC 机构。它是我们的试点项目和其他正在进行的研究取得成功的关键，这些研究由 达特茅斯CF研究社区的成员。反恐委员会有四个具体目标：(1) 支持设计和批准慢性阻塞性肺疾病临床和转化研究研究，(2)促进收集 来自CF患者和对照对象的样本和数据，(3)将临床样本存档，以供当前和 未来的研究，以及(4)有效地处理和分析临床标本。通过这些目标， 我们寻求支持研究，以提高我们对整个系统范围内的CF的理解 以开发出尽可能好的治疗方法和治疗方法。 好了！

The mission of the P30-supported DartCF Clinical and Translational Research Core (CTRC) is to increase translational research in studies on the effects of cystic fibrosis disease and treatments on the gastrointestinal tract and organ systems other than the lung. The CTRC supports basic science investigators and physician-scientists by facilitating access to and analysis of clinical specimens from patients with cystic fibrosis and comparator populations. The CTRC provides assistance with all aspects of research with human subjects including study design and approval, implementation, and analysis. In addition, by acting as a central clearinghouse, the CTRC works to coordinate our portfolio of clinically based studies to minimize the burden on our patient population and clinical care team and maximize scientific impact. Samples collected include stool, serum, urine, purified immune cells, bacterial and fungal clinical isolates from patient samples and accompanying patient data as allowed by IRB-approved protocols. The CTRC is able to collect patient samples as part of both longitudinal and cross-sectional studies; longitudinal studies in which samples are paired with patient health measures are particularly important for the analysis of the effects of the gastrointestinal microbiota on outcomes. The CTRC has developed a collection of banked samples for rapid hypothesis testing and this resource can be particularly useful for obtaining preliminary data for new studies. The CTRC is available to all CF researchers at Dartmouth and partner institutions. It is central to the success of our Pilot Projects and other ongoing studies directed by members of the Dartmouth CF research community. The CTRC has four specific aims which are: (1) to support the design and approval of CF clinical and translational research studies, (2) to facilitate collection of specimens and data from CF patients and control subjects, (3) to archive clinical samples for current and future research studies, and (4) to process and analyze clinical specimens efficiently. Through these aims, we seek support research that works towards improving our understanding of CF as a systems-wide disease in order to develop the best possible treatments and cures. !