AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

• 批准号: 10686329
• 负责人: Jeffrey Michael Bethony
• 金额: $ 483.11万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10686329
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; Acquired Immunodeficiency Syndrome; Adherence; Adult; Affect; Africa South of the Sahara; African American; Area; Arizona; Basic Science; Biological; Biological Specimen Banks; Caribbean region; Cause of Death; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Collection; Complex; Consent; Data; Data Pooling; Development; Economic Burden; Eligibility Determination; Ensure; Epidemic; Equipment and supply inventories; Equity; Evolution; Fostering; Freezing; Funding; Geographic Locations; Goals; Growth; HIV; HIV/AIDS; Head; Health; Hepatitis B Virus; Hepatitis C virus; Hispanic Americans; Hodgkin Disease; Human Herpesvirus 4; Human Papillomavirus; Incidence; Individual; Infection; Informatics; Institution; International; Kaposi Sarcoma; Latin America; Latin American; Leadership; Link; Liquid substance; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Marketing; Medical; Methodology; Mission; Morbidity - disease rate; Network Infrastructure; Non-Hodgkin' s Lymphoma; Outcome; Pathogenesis; Pathologic; Patients; Persons; Play; Prevalence; Process; Public Health; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Science; Scientist; Site; Smoking; Specimen; Standardization; Structure; Technology; Testing; Time; Tissue Sample; Translational Research; Tumor Tissue; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Universities; Viral; Washington; Work; aging population; antiretroviral therapy; biobank; cancer epidemiology; cancer risk; cancer specimen resource; cancer therapy; cancer type; co-infection; cofactor; epidemiologic data; fitness; immune function; informatics infrastructure; men; mortality; new technology; novel; older patient; outreach; programs; sample collection; skills; success; tumor microenvironment; virtual; virtual repository; virus related cancer; working group

Abstract The AIDS epidemic, initially recognized in the early 1980's, currently affects more than 35 million people worldwide. Infection with the human immunodeficiency virus (HIV) is associated with a wide range of long term health complications including the development of cancer, currently a major cause of death among persons living with HIV/AIDS. The early form of the AIDS and Cancer Specimen Resource (ACSR) was established in 1994 as a cooperative agreement with the NCI with a mission to provide high quality biospecimens to researchers, a mission still paramount for the current ACSR. Principle investigators (MPIs) from the two legacy sites (GWU and UCSF) oversee the function of the ACSR to ensure the adherence to NCI best practices in this multinational program. The ACSR is currently the custodian for specimen collections from more than 20,000 individuals and makes these biospecimens available to eligible researchers studying HIV and cancer through an established specimen application process. In the past five years, investigators from more than 50 institutions have received research material from the ACSR. In addition, the ACSR has provided the centralized biospecimen collection and distribution functions for the AIDS Malignancy Consortium (AMC), which represents the NCI-funded international network of more than 30 clinical institutions involved in testing novel cancer therapies in HIV-infected individuals. The ACSR is structured into regional biospecimen repositories (RBRs) located in distinct geographical regions that reflect the US and global HIV epidemic and are unified (virtually) by an informatics infrastructure managed by the Hub for Integrated Informatics and Research Support (HIIRS). The RBRs are distinct but complementary in their diverse functions, with collaborative interactions fostered through the Governing Committee and ACSR-wide Working Groups that accomplish activities related to Science and Technology, Marketing and Outreach, Informatics, and Quality Management. As the HIV epidemic has evolved the types of cancers and the technologies used to study them have also changed. The newly reconfigured ACSR will have two divisions, both focused on obtaining the most important well-annotated (demographic, clinical, pathological and outcomes data) biospecimens for research as defined by investigator inquiries and the ACSR's scientific advisory board. The two MPIs, respectively will head the national and international AMC support program and the scientific direction of the ACSR. Both MPIs will work within the structure of the ACSR to obtain and provide to researcher's specimens most important for research in the current epidemic. Specific Aims include: 1) Acquire, store, and equitably distribute tumor tissues and biological fluids from individuals with HIV-associated malignancies (AIDS-defining cancers and non-AIDS defining cancers) to meet the biospecimen needs of researchers in HIV-associated malignancies; and 2) Promote the success of AMC clinical trials through mutually beneficial collaborations.

抽象的 艾滋病的流行病最初在1980年代初承认，目前影响超过3500万人 全世界。人类免疫缺陷病毒（HIV）的感染与长期的广泛范围有关 健康并发症，包括癌症的发展，目前是生活中的主要死亡原因 与艾滋病毒/艾滋病。艾滋病和癌症标本资源（ACSR）的早期形式是在1994年建立的 与NCI达成的合作协议，其使命是为研究人员提供高质量的生物测量 当前ACSR的任务仍然至关重要。 来自两个传统站点（GWU和UCSF）的主要研究人员（MPI）监督ACSR的功能 确保遵守该跨国计划中的NCI最佳实践。 ACSR目前是托管人 对于来自20,000多人的标本收集，并使这些生物测量可用于合格 研究人员通过既定的标本申请过程研究艾滋病毒和癌症。在过去的五个 多年来，来自50多家机构的研究人员已从ACSR收到研究材料。此外， ACSR为AIDS恶性肿 财团（AMC），代表NCI资助的30多个临床机构的国际网络 参与了HIV感染者的新型癌症疗法。 ACSR结构为区域 位于反映美国和全球艾滋病毒的不同地理区域中的生物传播存储库（RBR） 流行病，并由集成枢纽管理的信息学基础架构（实际上）统一 信息学和研究支持（HIIRS）。 RBR是不同的，但在各种功能上是互补的， 通过管理委员会和ACSR范围的工作组促进了协作互动 完成与科学和技术，营销和外展，信息学以及质量有关的活动 管理。 随着艾滋病毒流行的发展，癌症的类型，用于研究它们的技术也有 改变了。新重新配置的ACSR将有两个部门，都专注于获得最重要的 定义的研究（人口统计学，临床，病理和结果数据）生物测量 由调查员查询和ACSR的科学顾问委员会。这两个MPI分别将领导 国家和国际AMC支持计划以及ACSR的科学方向。两个MPI都可以工作 在ACSR的结构中，以获取并提供研究人员的标本，最重要 当前的流行病。具体目的包括：1）获取，存储和公平分布肿瘤组织和 来自患有HIV相关的恶性肿瘤的个体的生物液（定义癌症和非AIDS 定义癌症）以满足研究人员在与HIV相关的恶性肿瘤中的生物测量需求；和2） 通过互惠互利的合作促进AMC临床试验的成功。

项目成果

Management of Localized Prostate Cancer in Men With Human Immunodeficiency Virus: Analysis of a Large Retrospective Cohort.

人类免疫缺陷病毒男性局限性前列腺癌的治疗：大型回顾性队列分析。

• DOI: 10.1016/j.clgc.2023.04.012
• 发表时间: 2023
• 期刊: Clinical genitourinary cancer
• 影响因子: 3.2
• 作者: Vaziri,Tina;Rao,YuanJ;Whalen,Michael;Bethony,Jeffrey;Thakkar,Punam;Lin,Jianqing;Goyal,Sharad
• 通讯作者: Goyal,Sharad

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer.

• DOI: 10.3791/63086
• 发表时间: 2022-06-10
• 期刊: Journal of visualized experiments : JoVE
• 作者: Wisner L;Larsen B;Maguire A
• 通讯作者: Maguire A

Collaborating with a Graduate Marketing Class to Boost Awareness of the AIDS and Cancer Specimen Resource.

• DOI: 10.1089/bio.2021.0025
• 发表时间: 2021-10
• 期刊: Biopreservation and biobanking
• 影响因子: 1.6
• 作者: Maddox LM;Silver S
• 通讯作者: Silver S

The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost.

• DOI: 10.1186/s12981-023-00558-4
• 发表时间: 2023-08-28
• 期刊: AIDS research and therapy
• 影响因子: 2.2

Biorepository best practices for research and clinical investigations.

• DOI: 10.1016/j.cct.2021.106572
• 发表时间: 2022-05
• 期刊: CONTEMPORARY CLINICAL TRIALS
• 影响因子: 2.2
• 作者: Sanderson-November, Micheline;Silver, Sylvia;Hooker, Vanessa;Schmelz, Monika
• 通讯作者: Schmelz, Monika