Wearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications

适用于闭环 TMS/fMRI/EEG 应用的可穿戴 RF-EEG 帽

• 批准号: 10688279
• 负责人: Lucia Isabel Navarro de Lara
• 金额: $ 16.36万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688279
• 关键词: Acceleration; Address; Anatomy; Area; BRAIN initiative; Basic Science; Brain; Brain Diseases; Brain imaging; Brain region; Career Choice; Cephalic; Clinical; Complement; Data; Deep Brain Stimulation; Electroencephalography; Electronics; Electrophysiology (science); Elements; Engineering; FDA approved; Feedback; Functional Magnetic Resonance Imaging; Future; Goals; Hand; Head; Helmet; Human; Image; Imaging Techniques; Individual; Intervention; Knowledge; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Measurement; Measures; Mentors; Methodology; Methods; Modality; Monitor; Morphologic artifacts; Multimodal Imaging; Neurons; Neurosciences; Obsessive-Compulsive Disorder; Outcome; Patients; Pattern; Performance; Phase; Prefrontal Cortex; Research; Resolution; Shapes; Signal Transduction; Structure; System; Technology; Testing; Therapeutic; Therapeutic Effect; Time; Training; Transcranial magnetic stimulation; Translating; Treatment Protocols; Validation; brain dysfunction; brain electrical activity; clinical application; clinical efficacy; data acquisition; design; experimental study; fabrication; flexibility; healthy volunteer; hemodynamics; improved; individual variation; individualized medicine; instrumentation; multimodal neuroimaging; multimodality; neuroimaging; neurophysiology; neuroregulation; noninvasive brain stimulation; novel; operation; programs; psychiatric symptom; radio frequency; reduce symptoms; simulation; skills; spatiotemporal; technology validation; temporal measurement; tool; usability

Project Summary Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in humans. A key component behind state-of-the-art fMRI is the multichannel radio frequency (RF) receive coil technology, which enables parallel imaging acceleration for improved spatial and temporal resolution. However, these imaging coils are usually fabricated on a hard helmet-shaped plastic chassis. This constitutes a critical barrier for multimodal approaches combining fMRI with other non-invasive brain imaging and stimulation methods such as electroencephalography (EEG) and transcranial magnetic simulation (TMS). While invaluable for large-scale imaging of both superficial and deep brain structures with high resolution, fMRI is an indirect measure of neuronal activity: it assesses brain function through the measurement of hemodynamic changes driven by local neuronal activity. Therefore, research approaches that combine fMRI with TMS would greatly benefit from the capability to concurrently also record EEG to obtain a direct neurophysiological measure of the underlying electrical brain activity. Specifically, the availability of simultaneously acquired EEG data would help us to (i) address fundamental questions on the mechanisms of TMS-induced changes in network-level brain activations and (ii) enable closed loop therapeutic applications for individually tailored treatment protocols. We propose to overcome the critical technological barriers for combined non-invasive stimulation (TMS) and multimodal imaging (EEG-fMRI) by applying flexible RF coil technology. Our overarching goal is to build and test a first-of-its-kind TMS compatible integrated multimodal imaging array, a “RF-EEG cap”, to allow simultaneous fMRI and EEG acquisition concurrently with TMS. To achieve this, we will employ flexible TMS-compatible RF coil elements sewed to a specifically tailored cap directly integrated with a commercial MRI compatible EEG cap. Used in conjunction with an MRI-compatible TMS coil to modulate ongoing brain activity, the system will enable studies of causal relationships between brain regions noninvasively with unprecedented spatiotemporal resolution, thus contributing to one of the main goals of the BRAIN Initiative. The project utilizes the extensive knowledge of the team mentors and collaborators in the fields of RF coil design and TMS/multimodal imaging and the availability of MR compatible TMS and EEG systems at MGH/Martinos Center. The candidate’s goal is to achieve the skills needed to launch her independent long-term research program on developing multimodal TMS/EEG/fMRI instrumentation and applying these methods in studies on the human brain. The proposed project will complement the candidate's strong prior expertise in designing and building TMS-compatible MRI hardware. The main training elements are 1) to extend the applicant's RF engineering skills to optimize the proposed flexible RF coil technology and 2) to advance her simultaneous multimodal neuroimaging/stimulation expertise for leading projects that use EEG/fMRI/EEG to test human neuroscience hypotheses.

项目摘要 功能磁共振成像(FMRI)是基础研究和临床神经功能成像的主流方法。 人类。最先进的功能磁共振成像背后的一个关键组件是多通道射频(RF)接收线圈 技术，这使得并行成像加速，以提高空间和时间分辨率。然而， 这些成像线圈通常是在坚硬的头盔形状的塑料底盘上制造的。这构成了一个关键的 将fMRI与其他非侵入性脑成像和刺激相结合的多模式方法的障碍 脑电(EEG)、经颅磁模拟(TMS)等方法。虽然是无价之宝 对于高分辨率的大脑浅层和深层结构的大规模成像，fmri是一种间接的方法。 神经元活动的测量：它通过测量血液动力学变化来评估大脑功能 由局部神经元活动驱动。因此，将功能磁共振成像与经颅磁共振仪相结合的研究方法将大大 受益于同时记录EEG的能力，以获得对 潜在的脑电活动。具体地说，同时采集脑电数据的可用性将有所帮助 美国将(I)解决TMS诱导的网络水平大脑变化机制的基本问题 激活和(Ii)实现针对单独定制的治疗方案的闭合环路治疗应用。 我们建议克服联合非侵入性刺激(TMS)和 应用柔性射频线圈技术进行多模式成像(EEG-fMRI)。我们的首要目标是构建和测试 一种首创的与TMS兼容的集成多模成像阵列，一种“RF-EEG帽”，允许同时 在TMS的同时进行fMRI和EEG采集。为此，我们将采用灵活的TMS兼容射频 线圈元件缝合到专门定制的盖上，直接与商业MRI兼容的EEG盖集成在一起。 与MRI兼容的TMS线圈一起使用来调节正在进行的大脑活动，该系统将使 用史无前例的时空无创研究脑区之间的因果关系 决议，从而为大脑倡议的主要目标之一作出贡献。该项目利用了广泛的 团队导师和合作者在射频线圈设计和TMS/多模式成像领域的知识 并在MGH/Martinos中心提供与MR兼容的TMS和EEG系统。候选人的目标是 获得所需的技能，以启动关于发展多式联运的独立长期研究计划 TMS/EEG/fMRI仪器，并将这些方法应用于人脑研究。建议数 该项目将补充候选人在设计和构建与TMS兼容的MRI方面的强大先前专业知识 硬件。主要的培训内容是1)扩展申请者的射频工程技能，以优化 提出了灵活的射频线圈技术和2)以促进HER同时进行多模式神经成像/刺激 在使用EEG/fMRI/EEG来测试人类神经科学假说的领先项目方面的专业知识。